Searchable abstracts of presentations at key conferences in endocrinology

ea0063s16.1 | Thyroid in pregnancy | ECE2019

Thyroid autoimmunity and (in)fertility

Unuane David

Thyroid autoimmunity (TAI) is the most frequent autoimmune disorder in women of childbearing age and increases the risk of thyroid dysfunction. TAI has been shown to be more common in women seeking counselling for infertility. The underlying causal mechanism that may account for any possible detrimental effect of TAI on fertility aspects remains hypothetical. In general, increased levels of anti-thyroid peroxidase abs (TPO-abs) have been defined as the most sensitive marker of...

ea0056d5.2 | Pregnant women should be screened for thyroid hormones and antibodies | ECE2018

AGAINST: ‘Pregnant women should be screened for thyroid hormones and antibodies’

Velkeniers Brigitte , Unuane David

Screening is a process of identifying apparently healthy people at increased risk of a disease or condition. They can then be offered appropriate treatment to reduce the risk arising from the disease or condition.Thyroid autoimmunity (TAI), defined by the presence of antibodies against thyroperoxidase and thyroglobulin, have been associated with adverse pregnancy outcomes, infertility, and impaired child neurodevelopment. However, associations do not nec...

ea0070aep1006 | Hot topics (including COVID-19) | ECE2020

Variable mineralocorticoid function in autoimmune Addison’s disease – a case report

De Rop Jonas , Unuane David , Velkeniers Brigitte

Autoimmune Addison’s disease (AAD) is widely believed to be associated with total loss of endogenous mineralocorticoid and glucocorticoid production and secretion, due to cell-mediated immune destruction. Therefore, patients with AAD are prescribed lifelong mineralocorticoid and glucocorticoid replacement therapy. We present a case of a 69 year old women known with polyglandular autoimmune disease type 2 (hypothyroidism, Addison’s disease and premature ovarian fail...

ea0022s13.3 | The TSH reference range | ECE2010

A critical synopsis of meta-analysis in the field of subclinical thyroid disease

Velkeniers Brigitte , Van Meerhaeghe Alain , Unuane David , Haentjens Patrick

Background: Currently, physicians remain uncertain whether to screen and/or treat subclinical thyroid disease. Many observational studies, including cross-sectional, case–control, and prospective cohort studies, have reported on the association between subclinical thyroid disease and an ‘outcome of interest’. All cause mortality, coronary heart disease, fracture risk, and pregnancy outcome may drive the decision to screen or treat subclinical thyroid disease.</p...

ea0088009 | Abstracts | BES2022

The course and outcome of subacute thyroiditis: a retrospective analysis and predictive model

Filette Jeroen de , Mey Lynn De , Rop Jonas De , David Unuane , Kurt Barbe , Bert Bravenboer

Background: Subacute thyroiditis (SAT) is a destructive thyroiditis of probable viral origin. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain largely unclear.Methods: A retrospective analysis of patients with SAT at the University Hospital of Brussels from 2001-2020 w...

ea0049gp41 | Bone & Calcium Homeostasis 1 | ECE2017

Follow-up of patients with surgical hypoparathyroidism: unknown cause of renal function decline?

van de Meerhaeghe Tess , Bukovski Sergei , Coudenys Elien , Unuane David , Velkeniers Brigitte , Bravenboer Bert

Background: Hypoparathyroidism is a rare endocrine disease with low calcium and insufficient parathyroid hormone levels. In most cases it is caused by thyroid surgery. The objective of this retrospective cohort study was to evaluate if the typical therapy regimens of postsurgical hypoparathyroidism with calcitriol have a negative effect on renal function. Methods: We performed a chart analysis of patients that were seen in a tertiary care hospital in Bru...

ea0079019 | Abstracts | BES2021

COVID-19 & Cushing’s disease in a patient with ACTH-secreting pituitary carcinoma

Jeroen M.K. de Filette , Bastiaan Sol , Gil Awada , Corina E. Andreescu , David Unuane , Duc Nam Nguyen , Sandrine Aspeslagh , Jan Poelaert , Brigitte Velkeniers , Bert Bravenboer

Background : The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of an unprecedented scale, with an ever-growing impact on healthcare systems. The clinical presentation of coronavirus disease 2019 (COVID-19) is diverse, ranging from asymptomatic illness to respiratory failure requiring admission to the intensive care unit (ICU). Risk factors for severe presentation include old age, male gender, underlying comorbidities such as metabolic syndr...