Endocrine Abstracts

The prevalence of obesity has greatly increased worldwide in the last decades, particularly in Europe and Portugal. It is associated with many health problems, including cardiovascular diseases, cancer and diabetes.Methods: Revision of the clinical records of all 61 patients who underwent bariatric surgery between 2013 and 2015. Analysis of their metabolic profile prior to surgery and its evolution after the operation.Results: 61 p...

Background: A pheochromocytoma is a rare neuroendocrine tumor, originating from adrenomedullary chromaffin cells. The pre-surgical management of pheochromocytoma is classically performed with alpha-blockers. However, in some cases other pharmacological approaches can be considered.Objective: The aim of the study is to describe the clinical course of patients with pheochromocytoma prepared for surgery with calcium channel blockers (CCB).<p class="abst...

Multiple endocrine neoplasia type 1 (MEN-1) is characterized by an increased predisposition to the development of tumors of the endocrine tissues, such as parathyroid glands, anterior pituitary, and duodenopancreatic neuroendocrine tumors. It is an autosomal dominant disorder due to germline mutations in the MEN-1 tumor suppressor gene. This gene encodes the menin protein, which is involved in cell growth and differentiation, and in sensing or repairing DNA damage. We present ...

Primary amenorrhea is characterized by the absence of menstruation after the age of 14 without the development of secondary sexual characteristics or after the age of 16 with the development of these. Hypogonadotropic hypogonadism (HH) corresponds to an uncommon etiology of primary amenorrhea. In HH, the differential diagnosis includes Kallmann Syndrome, isolated hypogonadotropic hypogonadism and CHARGE Syndrome. The CHARGE syndrome corresponds to an extremely rare syndrome, w...

Introduction: Primary thyroid angiosarcoma (TAS) is a rare malignancy that arises from endothelial cells, and nearly all reported cases originate from the Alpine region of central Europe. Most of the patients are female, elderly, with a history of goiter. Generally, TAS arises as a painless infiltrating mass and patients present with compression symptoms due to the brisk tumor growth. Other TAS clinical presentations are varied and highly non-specific. Metastasis occur early i...

Tertiary hyperparathyroidism reflects parathyroid hyperplasia, with autonomous secretion of parathyroid hormone (PTH), in spite of high plasma calcium concentration. Parathyroidectomy is an efficient therapy for stabilization of calcium and PTH metabolism in patients with end-stage kidney disease.We report a case of a 68-year old man with end-stage kidney disease under hemodialysis for nine years, due to long-standing uncontrolled hypertension. He presen...

IntroductionGynecomastia is characterized by the abnormal enlargement of one or both male breasts due to proliferation of the glandular tissue, with many possible underlying causes. A documented rare cause of gynecomastia is chest trauma.Case reportWe present a case of a 53-year-old male patient, with a personal history of arterial hypertension and depressive disorder, medicated with fluoxetine, perindopril, ...

Introduction: A teratoma is a rare type of tumor deriving from the germ layer cells (ectoderm, mesoderm and endoderm), typically benign, more frequent in infants. Adult onset teratomas are most commonly gonadal cell tumors. Extra--gonadal teratomas generally affect the midline, most frequently anterior mediastinum, retroperitoneum, pineal and suprasellar area. Head and neck teratomas are an extremely rare entity and represent only 0.47–6% of all cases.<p class="abste...

IntroductionAdrenal cyst lesions are uncommon and only a few large series have been reported. The pathogenesis is unclear. Currently, adrenal cystic lesions are categorized into endothelial cysts, pseudocysts, epithelial cysts and parasitic cysts. In most cases they are found incidentally in asymptomatic patients or in patients with non-specific gastrointestinal symptoms. We describe three cases of adrenal cysts.Case report<p c...

IntroductionLeydig cell tumors are rare entities, representing less 0.1% of all ovarian tumors. Generally these tumors are benign and unilateral. Most originate from the hilus cells and, less frequently, from the ovarian cortical stroma. Leydig cell tumors are functioning tumors, frequently associated with virilization symptoms in post-menopausal women.Case reportWe report the case of a 77 year-old female pat...