Searchable abstracts of presentations at key conferences in endocrinology

ea0056s17.3 | Recent advances in Primary Adrenal Macronodular Hyperplasia | ECE2018

Diagnosis and Management of Primary Adrenal Macronodular Hyperplasia

Vassiliadi Dimitra Argyro

Macronodular adrenal hyperplasia refers to adrenal enlargement by large nodules that may be related to ACTH-dependent or ACTH-independent pathologies. The term Primary Macronodular Adrenal Hyperplasia (PMAH) was recently introduced to replace the term ACTH-independent macronodular adrenal hyperplasia, since in some cases paracrine ACTH production may contribute to cortisol secretion, and also to encompass cases of unilateral macronodular hyperplasia. PMAH is a heterogeneous di...

ea0056p682 | Steroid metabolism + action | ECE2018

Proteolytically cleaved forms of corticosteroid-binding globulin with low steroid-binding affinity are not present in human plasma

Hill Lesley , Vassiliadi Dimitra , Hammond Geoffrey

Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood and is a serine protease inhibitor family member. Plasma CBG has a reactive center loop (RCL) structure that when cleaved by specific proteases, including neutrophil elastase, results in a loss of high affinity steroid-binding activity. Measurements of CBG levels are typically based on functional assays of its steroid-binding capacity or immunoassays, including enzyme-linked immunosorbant assays (ELISAs)...

ea0022p45 | Adrenal | ECE2010

High prevalence of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas: implications to management

Vassiliadi Dimitra , Ntali Georgia , Vicha Eirini , Tsagarakis Stylianos

Although the prevalence of subclinical hypercortisolism (SH) in unilateral incidentalomas (UI) has been extensively reported, patients with bilateral incidentalomas (BI) have not been thoroughly investigated. Moreover, the management of BI poses great dilemmas if surgery is considered, since bilateral adrenalectomy leads to life-long replacement. In the present study, we aimed to describe the characteristics of patients with BI in comparison to their unilateral counterparts. W...

ea0081yi1 | Young Investigator Awards | ECE2022

Excessive bilateral adrenal hyperplasia associated with aldosterone synthase (CYP11B2) deficiency

Diamantopoulos Aristidis , Mourelatos Panagiotis , Sertedaki Amalia , Botoula Efthimia , Vassiliadi Dimitra , Tsagarakis Stylianos

Introduction: Congenital adrenal hyperplasia (CAH) encompasses a group of enzymatic defects in cortisol biosynthesis resulting in adrenal hyperplasia through chronic compensatory ACTH stimulation. Aldosterone synthase deficiency, however, is associated with normal cortisol secretion and there are no reports on whether it may be associated with adrenocortical hyperplasia.Case Presentation: A 37-year-old, Greek female was referred for further investigation...

ea0049ep1139 | Female Reproduction | ECE2017

Diagnostic performance of non-invasive markers for the presence of nonalcoholic fatty liver disease in premenopausal women with and without polycystic ovary syndrome

Vassilatou Evangeline , Lafoyianni Sophia , Vassiliadi Dimitra-Argyro , Ioannidis Dimitrios , Paschou Stavroula , Mizamtzidi Maria , Vryonidou Andromachi

Introduction: Several markers based on anthropometric and biochemical parameters like fatty liver index (FLI), lipid accumulation product (LAP) index and visceral adiposity index (VAI), have been proposed for the detection of nonalcoholic fatty liver disease (NAFLD).Objective: To evaluate the diagnostic performance of FLI, LAP and VAI as markers of NAFLD in premenopausal women with and without polycystic ovary syndrome (PCOS), assessed for hepatic steato...

ea0041ep822 | Obesity | ECE2016

Visceral adiposity index as a marker of hepatic steatosis in overweight and obese premenopausal women

Vassilatou Evangeline , Vassiliadi Dimitra , Lazaridou Helen , Koutsomitopoulos Nikitas , Kelekis Nikolaos , Hadjidakis Dimitrios , Dimitriadis George

Introduction: Visceral adiposity index (VAI), initially developed as an indicator of visceral adipose function for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD). However, the diagnostic performance of VAI as a marker of hepatic steatosis (HS) is still under investigation.Objective: To evaluate the accuracy of VAI as a marker of HS in a cohort of overweight and obese premenopau...

ea0035p950 | Steroid metabolism and action | ECE2014

Tissue cortisol vs lipolysis in ICU patients

Ilias Ioannis , Vassiliadi Dimitra , Theodorakopoulou Maria , Nikitas Nikitas , Tzanela Marinela , Apollonatou Sofia , Tsagarakis Stylianos , Dimopoulou Ioanna

Introduction: The interplay of cortisol (F) and adipose tissue is complex and in many aspects is still obscure. Plasma F has been shown to be positively associated with lipolysis.Aim: To study in adipose tissue indices of lipolysis vs tissue F with microdialysis (MD).Subjects and methods: We studied 46 mechanically ventilated patients with a diagnosis of septic/non-septic shock, systemic inflammatory response syndrome or s...

ea0022p701 | Obesity | ECE2010

The circulating pattern of adiponectin and resistin in critically ill patients with sepsis

Vassiliadi Dimitra , Tzanela Marinella , Dimopoulou Ioanna , Orfanos Stylianos , Kotanidou Anastasia , Armaganidis Apostolos , Tsagarakis Stylianos

Several alterations of the metabolic processes develop during sepsis. Adiponectin and resistin are amongst the main adipokines that may contribute to the metabolic adaptations observed in the context of critical illness. However, there is scarce data on the circulating pattern of these adipokines in human sepsis. Therefore we aimed to describe the variation in circulating levels of resistin and adiponectin during the course of sepsis and examine whether they are related to the...

ea0015p158 | Diabetes, metabolism and cardiovascular | SFEBES2008

Glucocorticoid metabolism in human obesity; increased 5α-reductase activity is associated with insulin resistance in both men and women

Tomlinson Jeremy , Hughes Beverly , Hughes Susan , Vassiliadi Dimitra , Arlt Wiebke , Stewart Paul

The role of endogenous glucocorticoid (GC) production and metabolism in the pathogenesis of obesity, insulin resistance and type 2 diabetes remains unclear. Patients with Cushing’s syndrome develop central obesity, insulin resistance and in some cases type 2 diabetes (T2DM), yet circulating cortisol levels are not elevated in simple obesity. Alterations in GC metabolism, including 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that generates active cortisol ...

ea0015p274 | Pituitary | SFEBES2008

Use of the morning urinary cortisol to creatinine ratio in the diagnosis of mild Cushing’s disease in patients with discordant test results

Vassiliadi Dimitra A , Holder Geoff , Johnson Alan P , Arlt Wiebke , Stewart Paul M

The diagnosis of Cushing’s syndrome (CS) remains a major clinical challenge especially in a proportion of patients that have discordant results in the available tests. Although the measurement of 24-h urine free cortisol (UFC) is a useful test for the diagnosis of CS, 10–15% of patients have at least one measurement within the normal range and multiple measurements may be required in order to raise its sensitivity. In this study we sought to evaluate the value of the...