Searchable abstracts of presentations at key conferences in endocrinology

ea0056s17.3 | Recent advances in Primary Adrenal Macronodular Hyperplasia | ECE2018

Diagnosis and Management of Primary Adrenal Macronodular Hyperplasia

Vassiliadi Dimitra Argyro

Macronodular adrenal hyperplasia refers to adrenal enlargement by large nodules that may be related to ACTH-dependent or ACTH-independent pathologies. The term Primary Macronodular Adrenal Hyperplasia (PMAH) was recently introduced to replace the term ACTH-independent macronodular adrenal hyperplasia, since in some cases paracrine ACTH production may contribute to cortisol secretion, and also to encompass cases of unilateral macronodular hyperplasia. PMAH is a heterogeneous di...

ea0056p682 | Steroid metabolism + action | ECE2018

Proteolytically cleaved forms of corticosteroid-binding globulin with low steroid-binding affinity are not present in human plasma

Hill Lesley , Vassiliadi Dimitra , Hammond Geoffrey

Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood and is a serine protease inhibitor family member. Plasma CBG has a reactive center loop (RCL) structure that when cleaved by specific proteases, including neutrophil elastase, results in a loss of high affinity steroid-binding activity. Measurements of CBG levels are typically based on functional assays of its steroid-binding capacity or immunoassays, including enzyme-linked immunosorbant assays (ELISAs)...

ea0090p556 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cardiometabolic and bone health in postmenopausal women with glucocorticoid replacement therapy due to adrenal insufficiency; where do we stand

Kardalas Efstratios , Angelousi Anna , Argyro Vassiliadi Dimitra , Tsagarakis Stylianos

Background: Individuals with adrenal insufficiency (AI) receive life-long glucocorticoid (GC) replacement therapy (CGRT), which often exceeds normal daily physiological GC production, leading to detrimental effects on cardiometabolic parameters and bone health.Objective: Assessment of glucose, lipid and bone metabolism in AI postmenopausal patients in relation to the cause of AI and the CGRT dose.Methods: 114 AI postmenopausal wome...

ea0090p535 | Late-Breaking | ECE2023

Occurrence of thyroid autoimmunity, metabolic disorders and malignancy in patients with primary, non-syndromic hyperparathyroidism

Kardalas Efstratios , Ntali Georgia , Argyro Vassiliadi Dimitra , Tsagarakis Stylianos

Background/aim: Primary hyperparathyroidism (pHPT) is a relatively common endocrine disorder, which is often asymptomatic and thus diagnosed during routine biochemical testing. Emerging scientific data supports the theory that non-syndromic pHPT patients may be at increased risk for thyroid autoimmunity, metabolic disorders and malignancy.Materials and methods: A cohort of 227 pHPT (61 male and 166 female) and 244 non-pHPT (75 male and 169 female) patien...

ea0090p538 | Late-Breaking | ECE2023

How did COVID-19 pandemic affect the glycemic regulation of patients with type 1 diabetes mellitus and continuous insulin infusion systems? Experience of a single diabetes center

Kardalas Efstratios , Katechakis Nikolaos , Argyro Vassiliadi Dimitra , Tsagarakis Stylianos

Background and Aims: The COVID-19 pandemic severely affected the glycemic regulation of adult patients with type 1 diabetes (T1D). The aim of this study was to evaluate the impact of this pandemic on glycemic control in T1D patients with continuous subcutaneous insulin infusion (CSII) systems.Methods: A cohort of adult T1D patients with CSII was retrospectively evaluated. Data regarding number visits to our diabetes clinics, total daily insulin dose (TDI...

ea0022p45 | Adrenal | ECE2010

High prevalence of subclinical hypercortisolism in patients with bilateral adrenal incidentalomas: implications to management

Vassiliadi Dimitra , Ntali Georgia , Vicha Eirini , Tsagarakis Stylianos

Although the prevalence of subclinical hypercortisolism (SH) in unilateral incidentalomas (UI) has been extensively reported, patients with bilateral incidentalomas (BI) have not been thoroughly investigated. Moreover, the management of BI poses great dilemmas if surgery is considered, since bilateral adrenalectomy leads to life-long replacement. In the present study, we aimed to describe the characteristics of patients with BI in comparison to their unilateral counterparts. W...

ea0081yi1 | Young Investigator Awards | ECE2022

Excessive bilateral adrenal hyperplasia associated with aldosterone synthase (CYP11B2) deficiency

Diamantopoulos Aristidis , Mourelatos Panagiotis , Sertedaki Amalia , Botoula Efthimia , Vassiliadi Dimitra , Tsagarakis Stylianos

Introduction: Congenital adrenal hyperplasia (CAH) encompasses a group of enzymatic defects in cortisol biosynthesis resulting in adrenal hyperplasia through chronic compensatory ACTH stimulation. Aldosterone synthase deficiency, however, is associated with normal cortisol secretion and there are no reports on whether it may be associated with adrenocortical hyperplasia.Case Presentation: A 37-year-old, Greek female was referred for further investigation...

ea0049ep1139 | Female Reproduction | ECE2017

Diagnostic performance of non-invasive markers for the presence of nonalcoholic fatty liver disease in premenopausal women with and without polycystic ovary syndrome

Vassilatou Evangeline , Lafoyianni Sophia , Vassiliadi Dimitra-Argyro , Ioannidis Dimitrios , Paschou Stavroula , Mizamtzidi Maria , Vryonidou Andromachi

Introduction: Several markers based on anthropometric and biochemical parameters like fatty liver index (FLI), lipid accumulation product (LAP) index and visceral adiposity index (VAI), have been proposed for the detection of nonalcoholic fatty liver disease (NAFLD).Objective: To evaluate the diagnostic performance of FLI, LAP and VAI as markers of NAFLD in premenopausal women with and without polycystic ovary syndrome (PCOS), assessed for hepatic steato...

ea0041ep822 | Obesity | ECE2016

Visceral adiposity index as a marker of hepatic steatosis in overweight and obese premenopausal women

Vassilatou Evangeline , Vassiliadi Dimitra , Lazaridou Helen , Koutsomitopoulos Nikitas , Kelekis Nikolaos , Hadjidakis Dimitrios , Dimitriadis George

Introduction: Visceral adiposity index (VAI), initially developed as an indicator of visceral adipose function for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD). However, the diagnostic performance of VAI as a marker of hepatic steatosis (HS) is still under investigation.Objective: To evaluate the accuracy of VAI as a marker of HS in a cohort of overweight and obese premenopau...

ea0035p950 | Steroid metabolism and action | ECE2014

Tissue cortisol vs lipolysis in ICU patients

Ilias Ioannis , Vassiliadi Dimitra , Theodorakopoulou Maria , Nikitas Nikitas , Tzanela Marinela , Apollonatou Sofia , Tsagarakis Stylianos , Dimopoulou Ioanna

Introduction: The interplay of cortisol (F) and adipose tissue is complex and in many aspects is still obscure. Plasma F has been shown to be positively associated with lipolysis.Aim: To study in adipose tissue indices of lipolysis vs tissue F with microdialysis (MD).Subjects and methods: We studied 46 mechanically ventilated patients with a diagnosis of septic/non-septic shock, systemic inflammatory response syndrome or s...