Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep488 | Thyroid | ECE2020

Simultaneous papillary and medulary thyroid carcinoma – how to approach?

Martins Diana , Guelho Daniela , Vicente Nuno , Ventura Mara , Vieira Alexandra

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are distinct neoplasms, associated with different histological findings. Their coexistence in the same patient is a rare event, requiring a different clinical approach.Clinical case: A 72-year-old patient with no family history of thyroid disease, underwent total thyroidectomy in February 2019, due to toxic multinodular goitre, with no evidence of postoperative complica...

ea0090ep187 | Calcium and Bone | ECE2023

Hyperparathyroidism Jaw Tumour Syndrome in Pregnancy: A rare coexistence

Lopes Sofia , Monsanto Alice , Ferreira Mafalda , Ventura Mara , Ruas Luisa , Oliveira Patricia , Paiva Isabel

Introduction: Only <1% of cases of primary hyperparathyroidism (PHPT) occur during pregnancy. PHPT increases risk of complications such as miscarriage, premature birth and life-threatening maternal hypercalcemic crises. Hyperparathyroidism Jaw Tumor Syndrome (HPT-JT) is a rare inherited cause of PHPT, resulting from CDC73 gene mutations. There are a few reports described about HPT-JT in pregnancy. Although parathyroidectomy is the definite treatment for PHPT, given the sca...

ea0049gp35 | Bone & Calcium Homeostasis 1 | ECE2017

Aldosterone and parathyroid hormone – is there a connection?

Ventura Mara , Melo Miguel , Oliveira Diana , Martins Diana , Lages Adriana , Cunha Nelson , Carrilho Francisco

Introduction: Recent studies seem to support a bidirectional positive interaction between aldosterone and parathyroid hormone (PTH). Understanding the normal physiological relationship between renin-angiotensin-aldosterone system (RAAS) and PTH is of clinical interest because their inappropriate activity may negatively impact cardiovascular and skeletal health.Objective: To evaluate the presence of an interaction between aldosterone and PTH in a cohort o...

ea0049ep61 | Adrenal cortex (to include Cushing's) | ECE2017

Autoimmune Addison disease – data from long-term follow-up of patients from a tertiary hospital’s Endocrinology Department

Oliveira Diana , Paiva Isabel , Lages Adriana , Martins Diana , Ventura Mara , Cunha Nelson , Paiva Sandra , Carrilho Francisco

Introduction: Autoimmune Addison disease requires lifelong glucocorticoid and mineralocorticoid replacement. Optimal therapy is not standardized and must balance adequate hormone substitution with prevention of treatment-related complications.Objective: Assessment of patients followed at our department: epidemiology, associated conditions, treatment, cumulative hydrocortisone dose and comorbidities.Methods: Review of clinical recor...

ea0041ep818 | Obesity | ECE2016

Metabolically healthy obesity: exploring the paradox

Ventura Mara , Lages Adriana , Rodrigues Dircea , Oliveira Patricia , Melo Miguel , Martins Diana , Oliveira Diana , Carrilho Francisco

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

ea0056p156 | Paediatric endocrinology | ECE2018

Pediatric adrenal insufficiency: experience from a Tertiary Hospital Center

Ventura Mara , Cardoso Rita , Caetano Joana , Dinis Isabel , Melo Miguel , Bastos Margarida , Carrilho Francisco , Mirante Alice

Introduction: Adrenal insufficiency is a life-threatening disease caused by primary adrenal failure or secondary adrenal failure due to an impairment of hypothalamic-pituitary axis that affects adrenal cortisol synthesis. It is characterized by deficient production of glucocorticoids and may be associated with mineralocorticoid and androgens deficiency. Prompt diagnosis and management are essential and may even be life-saving.Methods: We retrospectively ...

ea0049ep203 | Neuroendocrinology | ECE2017

Quality of life in patients with neuroendocrine tumors treated with 177Lu-[DOTA0,Tyr3]-octreotate: a Single Tertiary Care Portuguese Center Experience

Lages Adriana , Moreira Helder , Costa Gracinda , Oliveira Patricia , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Carrilho Francisco

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

ea0049ep444 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Testosterone levels in men with diabetes mellitus. What relation?

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: Low serum testosterone (LST) is associated with some chronic diseases, changes in body composition and resistance to insulin. Diabetes is one condition that has high prevalence of LST.Objetive: To determine the prevalence of LST in men with diabetes and its relationship with age, anthropometric and biochemical data.Material and methods: A cross-sectional study of 65 men with type 1 and type 2 diabetes was conducted, wit...

ea0049ep445 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Vitamin D and testosterone in diabetes mellitus: cross-sectional study results

Cunha Nelson , Gomes Leonor , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fadiga Lucia , Catarino Diana , Carrilho Francisco

Background: In the recent years, Vitamin D role has grown in cardiovascular and inflammatory diseases, and some relations were made with low serum testosterone (LST) levels. It is equally known that in patients with diabetes, the prevalence of LST is higher.Objetive: To determine the prevalence of low levels of vitamin D and its relation with LST in men with diabetes.Material and methods: A cross-sectional study of 65 men with type...

ea0049ep1009 | Pituitary - Clinical | ECE2017

Aggressive pituitary tumors: a tertiary center experience

Lages Adriana , Paiva Isabel , Gomes Leonor , Oliveira Patricia , Belo Francisco , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Carrilho Francisco

Background: Pituitary adenomas (PA) are common intracranial tumors that are mainly considered benign. A small group of patients exhibit clinically aggressive behavior sometimes unrelated to the histopathological or radiological features.Methods: Twelve patients were selected harboring a PA with clinical features of aggressiveness. All the patients underwent pre and postoperative endocrinologic/neuroradiologic evaluation.Results: 10...