Searchable abstracts of presentations at key conferences in endocrinology

ea0081p499 | Thyroid | ECE2022

Variation of anti-TSH receptor antibodies after iodine-131 therapy

Vieira Ines , Monteiro Martim , Soeiro Paula , Rodrigues Dircea , Costa Gracinda , Paiva Isabel

Introduction: Graves’ disease (GD) is a systemic autoimmune disease characterized by lymphocyte activation and synthesis of anti-TSH receptor antibodies (TRABs). Higher values of TRABs are associated with a higher risk of Graves’ ophthalmopathy and dermatopathy. Iodine-131 therapy (RAI) is one of the well-established options in GD, but it can cause a transient increase in TRABs.Objectives: To evaluate the evolution of TRABs after RAI; to identi...

ea0081p580 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Hypoglycemia and impared hypoglycemia awareness: frequency and relevance in type 1 diabetes under continuous subcutaneous insulin infusion

Mafalda , Carreira Ana , Vieira Ines , Barros Luisa , Melo Miguel , Rodrigues Dircea , Oliveira Patricia , Baptista Carla , Moreno Carolina , Paiva Isabel

Introduction: Continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes (T1D) reduces the risk of hypoglycemia. Hypoglycemia remains a treatment-limiting factor. Impared hypoglycemia awareness (IHA) occurs in 25% of T1D cases and seems to be underestimated by continuous glucose monitoring (CGM). Glycemic variability (GV) is a increasingly valued parameter as a predictor of hypoglycemia and risk of chronic complications.Objective: Analysi...

ea0081p590 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes on continuous subcutaneous insulin infusion: impact of glycaemic control on quality of life

Carreira Ana , Ferreira Mafalda , Vieira Ines , Lavrador Mariana , Barros Luisa , Baptista Carla , Moreno Carolina , Melo Miguel , Paiva Isabel

Background: In type 1 diabetes (T1D), quality of life (QoL) and the effectiveness of treatment influence each other. QoL has been associated with glycaemic control assessed by HbA1c in T1D on continuous subcutaneous insulin infusion (CSII), but data on the relationship between Continuous Glucose Monitoring (CGM) metrics and QoL are scarce.Objectives: To assess QoL and the association between CGM metrics and QoL in T1D on CSII.Metho...

ea0081p450 | Reproductive and Developmental Endocrinology | ECE2022

Influence of polycystic ovary syndrome on in vitro fertilization and relationship with the Asn680Ser polymorphism in FSHR gene

Vieira Ines , Filipa Ferreira Ana , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Rodrigues Dircea , Cortesao Paulo , Almeida Santos Teresa , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility. Its influence on the results of in vitro fertilization (IVF) is controversial, and generally not isolated from the effect of obesity. A relationship between the FSH receptor (FSHR) polymorphism Asn680Ser and the risk and phenotype of PCOS has been studied with conflicting results.Objectives: To analyze the influence of obesity and PCOS on the gonadal axis...

ea0063p242 | Pituitary and Neuroendocrinology 1 | ECE2019

Pituitary tumors diagnosed in octogenarians – clinical implications

Cunha Nelson , Gomes Leonor , Paiva Isabel , Fadiga Lucia , Catarino Diana , Silva Diana , Guiomar Joana , Vieira Ines , Lavrador Mariana , Bastos Margarida

Introduction: The aging population brought new challenges in several diseases. Pituitary tumors are usually not related with elderly, although the rise in life expectancy has allowed its diagnosis in unusual age groups.Aim: To describe the pituitary tumors diagnosed in patients with age ≥ 80 yearsMethods: Retrospective observational study which included 23 patients with pituitary tumors with age ≥ 80 years observed in c...

ea0063p929 | Diabetes, Obesity and Metabolism 3 | ECE2019

Idiopathic versus autoimmune type 1 diabetes – long-term differences

Catarino Diana , Silva Diana , Pereira Claudia , Ribeiro Cristina , Ruas Luisa , Cunha Nelson , Fadiga Lucia , Guiomar Joana , Lavrador Mariana , Vieira Ines , Cardoso Luis , Paiva Isabel , Bastos Margarida

Introduction: The American Diabetes Association proposed two subcategories for type 1 diabetes: autoimmune type 1 diabetes (ADM) and idiopathic type 1 diabetes (IDM). The absence of β-cell autoimmune markers and lack of association with HLA haplotypes define the second category, whose pathogenesis remains unclear. Only a minority of patients with type 1 diabetes fall into this subcategory which is considered by several authors similar to type 2 diabetes.<p class="abst...

ea0063ep104 | Pituitary and Neuroendocrinology | ECE2019

Corticotroph adenoma associated with a rare infection – case report

Catarino Diana , Ribeiro Cristina , Cunha Nelson , Fadia Lucia , Silva Diana , Guiomar Joana , Lavrador Mariana , Vieira Ines , Saraiva Joana , Rodrigues Dircea , Paiva Isabel , Gomes Leonor , Bastos Margarida

Introduction: Cushing Syndrome have long been recognised to predispose patients to infection diseases, a consequence of the immunosuppression induced by corticosteroids. There is a predisposition to viral, bacterial, parasitic and especially fungal diseases. Opportunistic infections, particularly invasive fungal infections, represent a serious complication associated with an increased risk of mortality.Clinical case: We represent a 55 years-old woman, po...

ea0090p181 | Reproductive and Developmental Endocrinology | ECE2023

In Vitro Fertilization in Polycystic Ovary Syndrome: Treatment Individualization Based on Genetic Singularities

Carreira Ana , Vieira Ines , Reis Sandra , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Ferreira Ana , Rodrigues Dircea , Sousa Ana , Ramalho-Santos Joao , Cortesao Paulo , Almeida-Santos Teresa , Ramalhinho Ana , Moura-Ramos Mariana , Melo Miguel , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Polymorphisms in genes related to follicular recruitment and development, such as the follicle-stimulating hormone receptor (FSHR) and the oestrogen receptor 1 (ESR1) genes, and their impact on biochemical phenotype and response to controlled ovarian stimulation in women with PCOS have been studied in different populations, with inconsistent results.<p class="abstext...