Searchable abstracts of presentations at key conferences in endocrinology

ea0063s14.3 | Innovations in NETs | ECE2019

Fishing for NETs

Vitale Giovanni

Neuroendocrine tumors (NETs) are a class of rare and heterogeneous neoplasms derived from the neuroendocrine system. Animal models are indispensable tools for investigating the pathogenesis, mechanisms for tumour invasion and metastasis and new therapeutic approaches for cancer. Unfortunately, only few models are available for NETs, probably due to the rarity and heterogeneity of this group of neoplasms. The tropical teleost zebrafish (Danio rerio) is a popular vertebrate mode...

ea0032p1106 | Thyroid cancer | ECE2013

Serum calcitonin, thyrotropin, and goiter

Grani Giorgio , D'Alessandri Mimma , Del Sordo Marianna , Carbotta Giovanni , Vitale Martina , Fumarola Angela

Objective: Recent papers reported that basal calcitonin (CT) level may be related to thyroid volume. This study aims to evaluate if this finding is confirmed in patients undergoing ultrasonography-guided fine-needle aspiration cytology (FNAC) for thyroid nodules.Design: Retrospective university-center study.Methods: From February 2010 to September 2012, 561 patients underwent ultrasonography-guided FNAC and a complete evaluation in...

ea0022p562 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Assessment of biochemical control of acromegaly during treatment with somatostatin analogues: is there still a role for glucose oral load?

Carzaniga Chiara , Scacchi Massimo , Vitale Giovanni , Fatti Maria Letizia , Giraldi Francesca Pecori , Andrioli Massimiliano , Cavagnini Francesco

Biochemical control of acromegaly is currently defined by the achievement of GH suppression after oral glucose tolerance test (OGTT) and of normal age- and gender-matched IGF1 levels. OGTT is believed to inhibit somatotropin secretion by enhancing central somatostatinergic tone; thus, the use of this test in evaluating biochemical control in acromegalic patients on somatostatin analogues (SSA) is questionable. To gain further insights into this topic, we analyzed basal and nad...

ea0041oc14.1 | Thyroid Cancer | ECE2016

Tumor and normal thyroid stem-like cells: from tissues to zebrafish

Cirello Valentina , Vaira Valentina , Gaudenzi Germano , Stellaria Grassi Elisa , Vitale Giovanni , Ricca Dario , Bosari Silvano , Vicentini Leonardo , Persani Luca , Ferrero Stefano , Fugazzola Laura

Introduction: Cells with stem-like properties have been reported in benign and malignant thyroid diseases, and can be propagated by culturing them as non-adherent spheres.Design: Aim of the present study was to widely characterize the stem-like cells in tumor and normal thyroid tissues and in the corresponding in vitro-cultured thyrospheres, and to investigate in vivo the proangiogenic potential of thyrospheres in a zebrafish model....

ea0032p1080 | Thyroid cancer | ECE2013

A single-center, open-label, phase II, proof-of-concept study with pasireotide long-acting release in patients with progressive medullary thyroid cancer: 6-month evaluation

Faggiano Antongiulio , Ferolla Piero , Vitale Giovanni , Del Prete Michela , Ramundo Valeria , Esposito Raffaella , Marotta Vincenzo , Marciello Francesca , Carratu Anna Chiara , Camera Luigi , Fonti Rosi , Colao Annamaria

Introduction: Medullary thyroid cancer (MTC) is a well-differentiated neuroendocrine tumor in which somatostatin receptor (sst) expression is higher for sst1 and sst5 than for sst2. This may explain why the available sst2–selective analogues do not work in these patients and why pasireotide (SOM230), a novel, multi-receptor targeted somatostatin analogue with high-binding affinity for sst1,2,3 and sst5 coul...

ea0026p132 | Growth factors | ECE2011

Bone turnover and mineral density in thalassemia: relationships with gh secretory status and circulating somatomedins

Danesi Leila , Cattaneo Agnese , Scacchi Massimo , Sciortino Giovanna , Vitale Giovanni , Domenica Cappellini Maria , Arvigo Marica , Ferone Diego , Minuto Francesco , Cavagnini Francesco

Introduction: Previous data from our group suggested a role for the GH/IGF1 axis in the pathophysiology of osteoporosis in thalassemia (Clin Endocrinol 69:202, 2008). The present study was aimed at evaluating the relationships between circulating IGFs and bone metabolism and density in a very large series of adult thalassemic patients.Study design: One hundred and thirty-nine patients affected by thalassemia major (mean age 32.3±7.87 years) underwen...

ea0014p14 | (1) | ECE2007

Role of growth hormone/insulin like growth factor 1 system in the remodelling process of the right ventricle in top levels rowers

Vitale Giovanni , Galderisi Maurizio , Colao Annamaria , Innelli Pasquale , Guerra Germano , Guerra Ermelinda , Lloyd Dini Frank , Soscia Antonio , de Divitiis Oreste , Lombardi Gaetano

The intensive physical activity is often associated with cardiac changes, particularly involving the right ventricular (RV) chamber. However, the molecular mechanisms involved in the RV physiologic adaptation to long-term training are not completely understood. In the present study we investigated the role of the growth hormone/insulin like growth factor 1 (GH/IGF-1) axis in the RV remodeling of athletes.Nineteen male top levels rowers and 19 age-matched...

ea0099p390 | Late-Breaking | ECE2024

Progression of joint and psychological complications in acromegaly and their association with treatments and disease control

Cangiano Biagio , Premoli Caterina , Soranna Davide , Vitale Giovanni , Grottoli Silvia , Cambria Valeria , Maffei Pietro , Dassie Francesca , Cannavo Salvatore , Ragonese Marta , Zambon Antonella , Persani Luca , Fatti Letizia , Scacchi Massimo

Background: Articular and psychological complications of acromegaly are known to impair patients’ quality of life (QoL). The aims of this study are: (1) to look for clinical predictors for the progression of the articular and psychological complications, (2) to evaluate the progression of these complications in relation to the activity of the acromegalic disease, and (3) to evaluate how these complications interact to impair the QoL.Material and Met...

ea0081oc7.6 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

A tumor-borne Angpt2/Tie2 autostimulatory loop controls tumorigenesis

Pellegata Natalia , Minaskan Ninelia , Gulde Sebastian , Mohr Hermine , Geppert Julia , Rohm Maria , Vitale Giovanni , Gaudenzi Germano , Dicitore Alessandra , Franz Schilling , Schillmaier Mathias , Eisenhofer Graeme , Herzig Stephan , Roncaroli Federico , Honegger Jurgen

Background: Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non-resectable neoplasms associated to frequent relapse and significant comorbidities. As current treatments often fail against NF-PitNETs, identifying actionable therapeutic targets is essential. We focused on the angiopoietin-2 (Angpt2)/Tie2 axis, usually active in endothelial cells (ECs).Methods: ANGPT2 plasma levels in NF-PitNET patients and healthy controls were m...

ea0032p865 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

Carzaniga Chiara , Seravalle Gino , Attanasio Roberto , Grassi Guido , Cozzi Renato , Maria Fatti Letizia , Montini Marcella , Vitale Giovanni , Sciortino Giovanna , Damanti Sarah , Scacchi Massimo , Mancia Giuseppe , Cavagnini Francesco , Persani Luca

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...