Endocrine Abstracts

Background: Metabolic syndrome has been introduced to increase the incidence of cardiovascular diseases and type 2 diabetes mellitus. Our aim of this study was to investigate the relation for normal fasting plasma glucose levels and metabolic syndrome in normoglycemic adults.Methods: The study subjects consisted of 636 individuals who visited the Center for Health Promotion in Pusan National University Hospital for a medical checkup in 2002 to 2005. Amon...

Patient in the case, an 18-year-old male, complained of constant tiredness, frequent malaise, day time sleepiness, epigastric pain, poor appetite and consumption of great quantity of water. These conditions had persisted for 3–4 years. He had gone to many different physicians, with different tests taken, but without diagnose. Upon physical examination, the pale skin, scanty of pubic hair, and no presence of beard and axillary hair raised the possibility of Panhypopituitar...

AMP-activated protein kinase (AMPK) is a serine/threonine kinase which is evolutionally conserved from yeast to humans and is expressed in virtually all cell types including muscle, neurons and glial cells. We previously demonstrated that AMPK plays an important role in the regulation of peripheral intermediate metabolism by adipocytokines such as leptin and adiponectin, and that hypothalamic AMPK regulates food intake by responding to hormonal and nutrient signals. Our data i...

We have identified a signature that predicts response to androgen deprivation therapy in localized prostate cancer, and are now using this signature as a stratification variable on biomarker-driven clinical trials. Following up on the Stand-Up-To-Cancer sequencing findings we design a large umbrella trial which will personalize therapy based on actionable genomic alterations in metastatic castration-resistant prostate cancer.DOI: 10.1530/endoabs.42.IL12<...

Introduction: 2nd generation ‘Intact’ PTH assays currently available, measure 1–84 PTH and additional fragments. Recently a third generation kit developed which detects only active.1–84 PTH molecule, based on an immuno-radiometric sandwich assay.Design: Evaluation took place in an HMO central lab. 240 plasma samples collected. One hundred and sixty-one randomly out patients and 78 hospitalized nephrologic patien...

Recently basal insulin is the first recommended step when failed with oral medication, and adding morning NPH is one of step 1 intensive insulin treatment regimen when failed with basal insulin alone and post-lunch glucose level is high. But morning NPH or premixed insulin alone was the usual first step before basal insulin was available. When once a day morning insulin failed to reach target, next option was splitting twice a day injection. But many patients don’t agree ...

Aim: – to study functional status of pituitary–gonads (PG) axis in males with obesity.Materials and methods: We evaluated 15 males with obesity without other associated pathology. Mean age of patients was 28.3 years old. Control group constituted by 20 healthy men with different age.All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile (LH, FSH, prolactin, ...

The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia was shown to modulate the level of ERα expression and induce ligand-independent transcriptional activation of ERα, which may be intimately associated with the biology of breast carcinomas. Given that phosphorylation affects the transcriptional activity and stabilization of ERα, we examined the changes in phosphorylation of ERα under hypoxic conditions. H...

A new genetic animal model of type 2 diabetes, the Tsumura Suzuki Obese Diabetes (TSOD) mouse, has been developed in 1999. The TSOD mouse develops a moderate degree of obesity and diabetes. The aim of this study was to investigate the potential association of impairment of lipolysis and lipid metabolism on the development of obesity and diabetes in TSOD mice.Methods: Three month old TSOD and the age-matched control (TSNO: Tsumura Suzuki Non-Obesity) male...

Menopausal status is associated with weight gain, increased central fat mass, abnormal lipid metabolism, insulin resistance, and susceptibility to metabolic syndrome (MetS). Leptin is synthesized and secreted by adipocytes. Serum leptin levels are highly correlated with fat mass. We determined the association between MetS and serum leptin levels in 153 postmenopausal women. The difference in serum leptin level between MetS and non-MetS groups showed a statistical significance ...