Endocrine Abstracts

Introduction: Recent studies suggested that plasma levels of osteocalcin (OC) were negatively associated with both fat mass and plasma glucose. These findings may suggest that endocrine function of the osteoblast-derived osteocalcin on fat mass/glucose homeostasis in mice also might exist in humans. The aim of this study was to determine if osteocalcin has any effect on fat distrubution in different parts of body.Methods: Eighty-six obese premenapousal w...

ObjectiveIn this retrospective study we investigated the clinical and radiological characteristics, hormonal status and metabolic components of the patients with adrenal incidentaloma(AI). Additionally, we investigated whether tumor size or hormonal status changes during long-term follow-up and the effect of these on metabolic parameters.Methods: The data of 384 patients who were followed up with the diagnosis of AI between 2010 an...

Introduction: Gestational diabetes mellitus (GDM) is a condition that occurs during pregnancy when the body cannot produce enough insulin to handle the effects of a growing baby and changing hormone levels. Numerous studies reported that an increased risk of GDM among women who are overweight or obese compared with lean or normal-weight women.Methods/design: The purpose of this study is to compare anthropometric and biochemical parameters in postmenopaus...

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

Objective: Both overweight and obesity have been identified as risk factors for sexual dysfunction in men, but the relationship between female sexual function and amount of body fat is still obscure. To the best of our knowledge there are few reported studies assessing the relation between female sexual function index (FSFI) and body weight in women. Therefore, the aims of this study were to identify the frequency of sexual dysfunction (FSD) among obese women.<p class="abs...

Introduction: Primary hyperparathyroidism (PHPT) commonly goes unrecognized due to the physiological changes of pregnancy.PHPT is associated with significant maternal and fetal morbidity and mortality. Current evidence supports parathyroidectomy is the main treatment, performed preferably during the second trimester, when the serum calcium is above 11–mg/dl. We report the clinical course of a woman with newly diagnosed gestational PHPT who refused minimally invasive parat...

Objective: Insulin like growth factors (IGFs) are important regulators of pancreatic β cell devolopment, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF- 1 gene polymorphism in obese patients with insulin resistance.Methods: We included 100 obese pati...

Introduction: Acute myeloid leukemia infiltrates the CNS in up to 50% of cases. In contrast, the infiltration of the pituitary gland by leukemia cells is unusual. To date, AML presenting with central diabetes insipidus (CDI) has been rarely reported. Here, we present a patient with AML (subtype clasification is proceeding) presenting with panhypopituitarism and CDI.Case report: A 37-years-old man, with no significant past medical history, presented to Em...

Introduction: Pentraxin 3 (PTX3) is an acute-phase protein that shares structural homology with C-reactive protein (CRP). PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome (MetS) are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. In this study, we aimed to investigate...

Introduction: Megestrol acetate (MA) has been used in various cancers as a palliative agent to treat cancer cachexia. It has glucocorticoid activity and can induce significant secondary adrenal suppression. We designed this study to determine the extent of adrenal insufficiency in cancer patients receiving MA and find out whether ther was any predictive factor for this.Methods: Thirty-one patients (11 females and 20 males, aged 48–83 years) who were...