Searchable abstracts of presentations at key conferences in endocrinology

ea0035p349 | Diabetes (epidemiology, pathophysiology) | ECE2014

Profile of type 2 diabetic patients according to HbA1c tertiles in our tertiary health care center

Yurekli Banu Sarer , Kocabas Gokcen Unal

Aim: In this study we aimed to investigate general properties and treatment modalities of our type 2 diabetic patients.Materials and methods: A total of 136 consecutive type 2 diabetic patients were investigated. Type 2 diabetic patients were divided into three different groups according to HbA1c level (<7% group 1, 7–9% group 2, >9% group 3).Results: Mean age of our type 2 diabetic patients (F n=95, M n</...

ea0037ep82 | Adrenal cortex | ECE2015

Marked hypercholesterolaemia caused by mitotane adjuvant chemotherapy for adrenocortical carcinoma

Yurekli Banu Sarer , Kutbay Nilufer Ozdemir , Altun Ilker , Ozgen Gokhan

Aim: Mitotane (o,p′-DDD) has been used to treat adrenocortical carcinoma (ACC) for several decades. Mitotane is often given in adjuvant setting after surgical resection of ACC and treatment usually lasts 2–3 years to reduce ACC recurrence. The use of mitotane is associated with multiple adverse effects. We herein report a case of marked hypercholesterolemia in a man receiving mitotane as adjuvant chemotherapy for ACC.Case: A 64-year-old man wa...

ea0037ep208 | Reproduction, endocrine disruptors and signalling | ECE2015

An endocrine disrupting chemical, bisphenol A: could it be associated with sex differentiation in brain regarding to transsexuality?

Yurekli Banu Sarer , Kutbay Nilufer Ozdemir , Saygili Fusun

Transsexuality is characterised by a belief of having been born in a wrong body. Sexual differentiation of genitals take place in the first 2 months of pregnancy. Sexual differentiation of brain takes place in the second half of pregnancy. It is found that there is structural sex differences in the central nucleus of the bed nucleus of the stria terminalis (BSTc). Structural differences were found to be reversed in transsexual people. In humans main mechanism appears to involv...

ea0035p465 | Diabetes therapy | ECE2014

Metabolic control of our turkish diabetic patients on exenatide therapy: good at metabolic control but how about compliance?

Mirili Cem , Yurekli Banu Sarer , Kocabas Gokcen Unal , Kaya Zubeyde

Objective: Our aim is to evaluate the effect of exenatide treatment on body weight, HbA1c and compliance to treatment.Material and method: A total of 36 (five M and 31 F) type 2 diabetic patients who were prescribed exenatide were evaluated for this study. Body weight, BMI, HbA1c parameters and side effects were noted from the outpatient clinic records.Result: The median age of our patients was 52 years of old (19–79 years). M...

ea0035p1024 | Thyroid (non-cancer) | ECE2014

A case of thyrotoxic hypokalemic periodic paralysis presenting with ‘U’ wave on ECG

Gezer Emre , Yurekli Banu Sarer , Kocabas Gokcen Unal

Introduction: Hypokalemic periodic paralysis (HPP), is a rare neuromuscular disorder caused by dysfunction of the ion channels in red muscle cells which is characterized by painless episodes of muscle weakness generally after strenuous exertion or a high-carbohydrate meal. However, some HPP patients secondary to thyrotoxicosis are also described.Case: A 41-year-old Caucasian man, without any chronic disease, presented to our emergency department with gen...

ea0049ep1194 | Clinical case reports - Thyroid/Others | ECE2017

A case with langerhans cell histiocytosis having papillary microcarcinoma of thyroid: two birds in one nest

Ozisik Hatice , Yurekli Banu Sarer , Kutbay Nilufer Ozdemir , Altun Ilker , Ertan Yesim , Makay Ozer , Ozgen Gokhan

Introduction: Langerhans cell histiocytosis (LHH) is an idiopathic, clonal, pleomorphic, neoplastic disorder characterized by the presence of atypical histiocytic cells which are locally or commonly seen in bone, lung, hypothalamus, liver, lymph nodes, mucocutaneous tissues with damaging them.Case: 58 year-old male patient applied to our clinic due to fatigue. On his physical examination, lymphadenopathy and hepatosplenomegaly were absent. In his history...

ea0049ep1379 | Thyroid (non-cancer) | ECE2017

Effects of combination of metformin and pioglitazone on AMPK/mTOR signal pathway, p53 and apoptosis in human anaplastic thyroid cancer cells

Kutbay Nilufer Ozdemir , Erdogan Mehmet , Yurekli Banu Sarer , Kurt Cansu Caliskan , Gunduz Cumhur , Avci Cigir Biray

Thyroid cancer is the most common malignant tumor of the human endocrine system. Recently, its incidence has increased significantly. Anaplastic cancer constitutes 2–4% of thyroid cancers and remains aggressive. The life expectancy is 2–6 months. It is often beyond the surgical margin. External radiation therapy or chemotherapy are the treatment options. Therefore, new therapeutic approaches are needed. Peroxisome proliferator-activated receptor (PPAR) gamma is a DNA...

ea0037ep1339 | Clinical Cases–Thyroid/Other | ECE2015

A case of Swyer syndrome with gonadoblastoma and dysgerminoma

Yurekli Banu Sarer , Kutbay Nilufer Ozdemir , Ozen Samim , Karaca Emin , Acar Kamuran , Saygili Fusun

Aim: The Swyer syndrome belongs to a group of pure gonadal dysgenesis. Karyotype is 46,XY. Aberrations of chromosome Y or SRY gene mutation is present in 15–30% of cases. These patients have high gonadotropin levels and are classified as having hypergonadotropic hypogonadism. The Swyer syndrome in the female requires close followup because of the high risk of neoplastic transformation in the dysgenetic gonads. Herein we report a case of Swyer syndrome with gonadoblastoma ...

ea0035p406 | Diabetes complications | ECE2014

Is the ankle-brachial index directly associated with current glycemic control in diabetic patients? Preliminary results of our study

Yurekli Banu Sarer , Kocabas Gokcen Unal , Mirili Cem , Yurekli Ismail , Cakir Habib

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...

ea0035p895 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Six cases of FSH/LH positive pituitary adenomas

Kutbay Nilufer , Yurekli Banu Sarer , Erdogan Mehmet , Saygili Fusun , Ertan Yesim

Introduction: Immunocytochemistry methods have demonstrated that most of the ‘clinically non functional’ adenomas are actually gonadotrophin secreting adenomas or gonadotroph adenomas. Gonadotroph adenomas are discovered in patients presenting with visual field disorder. Pituitary imaging almost always demonastrates macroadenoma. Anterior pituitary insufficiency is much more frequent than gonad hyperstimulation. Herein, we present six cases of FSH and/or LH positive ...