Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep128 | Clinical case reports - Pituitary/Adrenal | ECE2017

DOC secreting adrenal adenoma, a rare cause of hypertension

Paja Miguel , Dublang Maddalen , Zabalegui Alba , Arrizabalaga Cristina , Exposito Amaia , Espiga Javier

Secondary endocrine hypertension affects around 10% of all hypertensive population, most frequently primary aldosteronism (PA). Less frequent forms of adrenal hypertension include pheochromocytomas and other causes of mineralocorticoid excess than PA, featuring suppressed renin without excess of aldosterone. Featuring. We present a 29-year-old woman with difficult to control hypertension diagnosed two years before and poor response to ACEI and ARA II treatment. She was referre...

ea0041ep55 | Adrenal cortex (to include Cushing's) | ECE2016

Outcome with surgical treatment in subclinical hypercortisolism

Moreno Cristina , Paja Miguel , Zabalegui Alba , Dublang Maddalen , Etxeberria Eider , Oleaga Amelia , Teresa Gutierrez M

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

ea0049ep112 | Clinical case reports - Pituitary/Adrenal | ECE2017

Paraganglioma (PG) and cyanotic congenital heart disease (CCHD): the role of tisular hypoxia

Oleaga Amelia , Goni Fernando , Paja Miguel , Ugarte Estibaliz , Moreno Cristina , Iglesias Natalia , Etxeberria Eider , Calles Laura , Dublang Maddalen , Zabalegui Alba

Introduction: CCHD comprises a number of different congenital heart defects associated with elevated pulmonary artery pressure and pulmonary vascular resistance, resulting in a reversed or bidirectional shunt (Eisenmenger syndrome). These entities develop systemic hypoxia. Pheochromocytoma and paraganglioma (PHEO/PG) are neuroendocrine tumours. Several inheritance genetic alterations have been reported in PHEO/PG syndromes. A pathogenic association between these entities is pr...

ea0041ep1017 | Thyroid (non-cancer) | ECE2016

Accuracy of repeated core biopsy (CB) after inadequate first CB in thyroid nodules

Paja Miguel , Zabala Rosa , Korta Igone , Zabalegui Alba , Dublang Maddalen , de Ciriza Maite Perez , Lizarraga Aitzol , Ugalde Aitziber

In our centre, thyroid core-biopsy (CB) has replaced fine needle aspiration biopsy (FNAB) in the study of thyroid nodules because its better accuracy. International guidelines recommend repeating the FNA in cases of inadequate or insufficient first specimen, but nothing is published about the case in failed CB.Objective: To study the differences between nodules with inadequate and diagnostic thyroid Core Biopsy and the accuracy of repeating a CB after a ...

ea0063p89 | Calcium and Bone 1 | ECE2019

Diagnostic and treatment delay in primary hyperparathyroidism (phpt): a pending issue

Paja Miguel , Martinez Adela L , Monzon Andoni , Arrizabalaga Cristina , Zabalegui Alba , Iglesias Natalia C , Calles Laura A , Etxeberria Eider M , Gutierrez Teresa

Background: PHPT is the leading cause of hypercalcemia in outpatients. Its clinical presentation varies from asymptomatic forms to renal or bone complications. The only curative treatment is surgical resection, and delayed diagnosis can lead to serious morbidity.Objective: Identify the presence of PHPT at least one year prior to referral to endocrinology consultation. Secondly, determine whether diagnostic delay leads to increased complications.<p cl...

ea0063p369 | Thyroid 1 | ECE2019

Impact of thyroid autoimmunity on obstetric and perinatal outcomes in pregnant women with subclinical hypothyroidism

Oleaga Amelia , Jimenez-Telleria Patricia , Goni Fernando , Moreno Cristina , Arrizabalaga Cristina , Izuzquiza Ana , Espiga Javier , Martinez Adela , Zabalegui Alba , Paja Miguel

Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal out...

ea0049ep1217 | Clinical case reports - Thyroid/Others | ECE2017

Simultaneous papillary and medullary thyroid carcinoma in siblings with RET 611 mutation. More than a coincidence?

Paja Miguel , Zabalegui Alba , Dublang Maddalen , Etxeberria Eider , Iglesias Natalia C , Calles Laura A , Arrizabalaga Cristina , Lizarraga Aitzol , Gutierrez M Teresa , Ugalde Aitziber

Germinal mutations of the oncogene RET originate the development of medullary thyroid carcinoma (MTC) in carriers with phenotypic expression depending on the mutated codon and other unknown factors. Simultaneous detection of differentiated thyroid carcinomas is considered a casual phenomenon (collision tumours). We communicate two brothers with double heterozygous mutation of maternal inheritance at codon 611 of RET, TGC to TTT, changing to encode phenylalanine (C611F), with a...

ea0056p1156 | Thyroid cancer | ECE2018

Diagnostic accuracy of CNB in tyroid nodules smaller than 1 centimeter

Paja Miguel , Ugalde Aitziber , Korta Igone , Zabala Rosa , Martinez Adela L , Zabalegui Alba , Arrizabalaga Cristina , Calles Laura A , Etxebarria Eider , Del Cura Jose L

Current guidelines suggest sonographic follow-up in thyroid nodules smaller than 10 mm with intermediate or highly suspicious features as ultrasound-guided FNAC has poor results in these nodules, and the risk of non-diagnosed thyroid carcinoma is very low. CNB has proved superior to repeated FNAC in case of insufficient or indeterminate first FNAC.Objective: Evaluate diagnostic accuracy of CNB in nodules smaller than 10 mm with intermediate or high suspi...

ea0056p1157 | Thyroid cancer | ECE2018

Serum thyroglobulin (sTg) before surgery in euthyroid patients with differentiated thyroid cancer (DTC)

Paja Miguel , Lizarraga Aitzol , Exposito Amaia , Teresa Gutierrez M , Barrios Borja , Iglesias Natalia C , Zabalegui Alba , Arrizabalaga Cristina , Martinez Adela L , Oleaga Amelia

sTg is universally accepted as the best marker of disease status in DTC. Its presurgical serum level may suggest the presence of distant metastasis in case of very high level, but the correlation between its level and the characteristics of the tumour is yet to be defined.Objective: To evaluate preoperative thyroglobulin as predictor of DCT features.Methods: Preoperative sTg was measured in patients operated for DTC between 2011&#1...