Endocrine Abstracts

Background: Turner syndrome (TS) is the most common chromosome deficiency in women, with an incidence of 1 in 2 000 female newborns. Acromegaly is a rare disease, which occurs with a frequency of 1:140 000–250 000 of the population. To our knowledge only several cases of TS and acromegaly coexistance have been reported up to date.Case presentation: A 43-year-old woman with TS was referred to our Department with an accidentally discovered pituitary m...

Introduction: Cushing disease, as a state of chronic hypercortisolism, causes diverse, often nonspecific symptoms, possibly delaying the proper diagnosis.Case report: A 59-year-old woman with the history of type 2 diabetes mellitus, hypertension, osteoporosis and multiannual history of recurrent hospitalizations because of life-threatening multi-sited soft tissue and muscle abscesses, was admitted to the Department of Internal Medicine and Metabolic Dise...

Background: Transsphenoidal adenomectomy of GH-secreting pituitary tumour is a first-line treatment of acromegaly. Pharmacological treatment is recommended if surgery did not lead to disease remission. Pathological assessment of postoperative tissue provides clinicians with valuable information on the disease course.Aim: The aim of this study was to assess whether clinical, imaging, and pathological characteristics can predict surgical remission and resp...

Introduction: Patients with connective tissue diseases are susceptible to the occurrence of side-effects of long term treatment with low-dose glucocorticoids as these medications often cannot be withdrawn due to exacerbation of the underlying disease. The new-onset of glucose metabolism impairment is not considered common in patients treated with low-dose glucocorticoids and the risk factors are thought to be the same as in general population: increasing age, obesity or family...

Diagnosis and treatment of Cushing’s disease is one of the greatest challenges of modern endocrinology. This is related to the fact that pituitary corticotropinomas are small tumours that are difficult to visualize in magnetic resonance imaging (MR). In about 40% of patients with Cushing’s disease, MR scans of the pituitary gland do not reveal any changes. The method that allows to localize the source of adrenocorticotropin (ACTH) secretion is bilateral inferior pe...

Background: The diagnostic process to unveil the underlying cause of endogenous Cushing’s syndrome (CS) is often challenging. Sometimes, atypical manifestation of the disease or only periodic hypercortisolaemia with spontaneous resolutions are observed and make the diagnosis even more difficult. Although it is common in primary pigmented nodular adrenocortical disease (PPNAD), pituitary corticotroph adenoma can manifest itself as cyclic Cushing’s syndrome as well.</p...