Searchable abstracts of presentations at key conferences in endocrinology

ea0022p211 | Clinical case reports and clinical practice | ECE2010

Unilateral Graves' orbitopathy and autoimmune atrophic thyroiditis: case report

Vlad Mihaela , Golu Ioana , Zosin Ioana

Graves’ orbitopathy (GO) represents ophthalmic symptoms that affect, usually, patients with Graves’ disease. Rarely, it can occur in subjects without thyroid dysfunction or with hypothyroidism (2–5% of the cases).In this report we present a rare case with unilateral GO and initial euthyroidism, which progressed to hypothyroidism, due to an autoimmune atrophic thyroiditis.A 39-year-old woman, long-term smoker, was ref...

ea0049ep1068 | Pituitary - Clinical | ECE2017

Sheehan’s syndrome in clinical practice

Vlad Mihaela , Golu Ioana , Amzar Daniela , Balas Melania , Butaru Miruna , Milos Ioana , Zosin Ioana

Sheehan’s syndrome represents a rare cause of pituitary insufficiency, produced by an ischemic pituitary necrosis due to a severe haemorrhage at deliverance. Epidemiologic data indicate that, nowadays, this disease is quite rare in developed country.Aim: To determine and evaluate the clinical and hormonal characteristics of cases with Sheehan’s syndrome diagnosed and follow-up in our Clinic, during the last ten years.Subj...

ea0035p893 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Post-partum pituitary insufficiency: diagnostic challenge

Amzar Daniela , Balas Melania , Golu Ioana , Vlad Mihaela , Zosin Ioana

Background: Postpartum hypopituitarism, known as Sheehan’s syndrome, occurs during a complicated childbirth, due to severe hemorrhage and hpovolemic shock that lead to ischemic necrosis of the pituitary gland.The aim of the study is to point out the clinical features in postpartum pituitary necrosis, so that the disease could be recognize rapidly, to present a laboratory work-up for a postive diagnosis, and also to describe the com...

ea0035p1016 | Thyroid (non-cancer) | ECE2014

Different therapeutic outcomes in two cases with active moderate-to-severe Graves'orbitopathy treated with intravenous steroid therapy-case presentation

Zosin Ioana , Vlad Mihaela , Balas Melania , Bolintineanu Carmen

Background: Graves’ orbitopathy (GO) comprises mild, moderate-to-severe and severe forms. The treatment is complex, depending on the activity and severity of the disease. Patients with active moderate-to-severe GO benefit by correction of thyrotoxicosis and glucocorticoids (GC), as first-line agents. Approximately 20-40% of cases are not responsive to GC therapy.Case presentations: There are presented two cases with active moderate-to-severe GO trea...

ea0022p590 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Sleeping apnea syndrome (SAS) in acromegaly and obesity

Amzar Daniela , Mihaicuta Stefan , Golu Ioana , Balas Melania , Zosin Ioana

The aim of the study: Acromegaly is associated with respiratory and cardiovascular morbidities and high mortality rate. The present study evaluates clinical aspects in acromegalic and obese patients with sleep apnea syndrome (SAS).Material and method: The patients were diagnosed and followed-up in the Clinic of Endocrinology, Timisoara, in the period 2006–2009. All the cases were confirmed and investigated as present guidelines recommend. The polyso...

ea0020p127 | Thyroid | ECE2009

Chronic autoimmune thyroiditis morpho-functional and immunological aspects

Crista Corina , Zosin Ioana , Marginean Otilia , Micle Ioana

The study group consists of 159 cases of chronic autoimmune thyroiditis (CAT) (age =40.48±15.22 years; F/M=156/3) distributed in 3 groups after the morpho-functional criteria: CAT with goiter – 48.43% cases (F/M=77/0); atrophic CAT – 33.33% cases (F/M=52/1); asymptomatic CAT – 18.24% cases (F/M=27/2). The thyroid ultrasonography allowed the thyroid volume measurement and the evaluation of the parenchyma echogenicity. Most of the cases presented a moderate (...

ea0016p751 | Thyroid | ECE2008

Same aspects regarding immunohistochemical diagnosis of papillary thyroid carcinoma

Zosin Ioana , Golu Ioana , Cornianu Marioara , Amzar Daniela , Balas Melania

The study evaluates the expression of same immunohistochemical (IHC) markers (Ki-67, PCNA, CK-19, HBME-1 and Galectin 3, in the diagnosis of differentiated thyroid carcinomas.Material and methods: The study group comprised 57 patients with thyroid tumors; aged 17–71 years (mean age 48.96 years). All cases were evaluated before surgical treatment by means of clinical examination, thyroid ultrasonography and fine needle aspiration biopsy (FNAB).<p...

ea0014p335 | (1) | ECE2007

Usefulness of Ki-67, PCNA, c-erbB-2 and CK 19 in the diagnosis of some thyroid follicular tumors

Zosin Ioana , Cornianu Marioara , Golu Ioana , Balas Melania , Milos Aurora

This study represents a complex evaluation of a group of 26 cases with thyroid nodular disease (TND), using different diagnostic methods. Clinically and by means of ultrasonography, 12 patients were suspected of malignancy. Fine-needle aspiration biopsy (FNAB) detected mainly suspicious (12 cases) and malignant smears (5 cases). The microscopic examination of surgical specimens established the following diagnosis: follicular adenoma – FA (4 cases), papillary hyperplasia &...

ea0049gp53 | Cardiovascular &amp; Lipid Endocrinology | ECE2017

Clinical, laboratory and cardiac parameters in overt primary hypothyroidism versus overt central hypothyroidism

Balas Melania , Parv Florina , Vlad Mihaela , Golu Ioana , Amzar Daniela , Zosin Ioana

Background: Hypothyroidism affects cardiac function, leading to cardiomyopathy, pericarditis, lower left ventricular performance, etc. The present study investigates different parameters (clinical, hormonal, biochemical, echocardiographic) in overt primary hypothyroidism (OPHypo) and overt central hypothyroidism (OCHypo).Material and methods: The study included 33 untreated patients with OCHypo (5 with empty sella, 3 with idiopathic hypopituitarism, 7 wi...

ea0037ep869 | Thyroid cancer | ECE2015

A rare case of an off midline thyroglossal duct cyst papillary thyroid carcinoma

Balas Melania , Golu Ioana , Amzar Daniela , Vlad Mihaela , Ianes Emilia , Dema Alis , Zosin Ioana

Introduction: Papillary thyroid carcinoma can be found very rarely in a thyroglossal duct cyst (TDC) (1%), this cancer variant being the most common type. Although, most of the TDC develop in the midline of the thyroglossal duct (~70%), some cysts occur off midline, within 2 cm of the midline.Case presentation: The female patient of 34-year-old presented at the Maxillofacial Surgery Department in October 2014, with a right submandibular painless neck mas...