Endocrine Abstracts

Introduction: A poor vitamin D status has been related to an increased risk of cardiovascular disease. Carotid intima–media thickness (IMT) has shown to be an early marker of subclinical atherosclerotic Therefore, we aimed at examining the association between vitamin D status and the extent of carotid IMT in type 2 diabetics.Subjects and methods: In a cross sectional study 78 type 2 diabetic patients attending the Diabetes and Endocrinology Clinic i...

Background: Diabetes is a risk factor for both PAD and PAD-associated mortality. Diabetic patients have worse arterial disease and a poorer outcome than nondiabetic patients. Fetuins are blood proteins made in the liver more abundant in fetal blood. Fetuin-A is regarded as an inhibitor of systemic calcification.Aim of this work: To assess the relationship between plasma fetuin-A levels and peripheral vascular disease in type 2 diabetes mellitus.<p cl...

Background and aims: Irisin is a novel myokine that promote energy expenditure. It could act on adipocyte metabolism through a novel neural pathway and on the other hand irisin induces neural proliferation and adequate neural differentiation. We aimed to assess serum irisin level in type 2 diabetics (T2DM) and correlate it with metabolic parameters. Also, we assessed the relation between irisin level and diabetic peripheral neuropathy (DPN).Methods: We r...

Introduction: Iodine is needed for the production of thyroid hormone. The prediction of iodine intake is difficult. The standard measure of iodine nutrition in a community is the median urinary iodine excretion, expressed in micrograms per liter. According to the WHO, a median urinary iodine excretion of 100–199 μg/l indicates that the iodine intake is adequate.The aim of this work is to measure the iodine excretion in patients with thyroid nod...

Introduction: One tenth of children worldwide are obese and disturbance in pubertal progression is one of the unpleasant health consequences of adolescent obesity. Data on pubertal hormones in obese adolescents are scarce and contradictory.Methods: This study was a cross-sectional, case-control study conducted on 120 participants; 60 randomly chosen obese adolescent males and 60 age and sex matched controls. All participants had measurements of their wei...

Objective: To determine the Predictors of growth response to GH treatment in a group of isolated idiopathic GH (GH).Patients and methods: 477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year up to 6 years. Multiple linear regressions were done to identify predictors of growth response to rhGH in the first 4 years of treatment.Results: In the first year, three ...

Insulin is a thyroid growth factor that stimulates proliferation of thyroid cells in culture. It has been observed that insulin receptors are over expressed in most thyroid tumors as an early step in thyroid carcinogenesis.Eighty women (mean age 36.85±4.71 years) were evaluated by a thyroid ultrasound (US), fasting plasma insulin and HOMA IR. Subjects were divided into four groups as follows: G1 (n: 24),subjects with IR and obesity; G2 (n<...

Background: There is accumulating evidence suggesting that altered vitamin D may play a role in the development of T2DM. A growing body of evidence suggests that low levels of vitamin D may adversely affect the cardiovascular system.Objective: This is to assess the relation of serum 25 OH vitamin D concentrations and risk of CVD in T2DM patients.Subjects and methods: Seventy subjects aged from 40 to 60 years were chosen excluding t...

Background: Obesity is a common feature of women with PCOS in different ethnic cohorts. It is suggested that retinol binding protein 4 (RBP4) is a central mediator of obesity-induced insulin resistance in mice and humans. In addition, elevated serum RBP4 levels have been associated with cardiovascular risk factors and metabolic syndromes.Aim: To investigate whether serum RBP4 level is correlated with metabolic parameters, indices of insulin resistance, a...

Introduction: Phaeochromocytomas commonly present with episodes of sweating, palpitations, and hypertension. Urinary catecholamines measurement is the most common screening test for suspected phaeochromocytoma in the UK. We report a series of three cases in which the reason for hypertension and raised catecholamines was not a phaeochromocytoma and treating the underlying condition corrected the clinical and biochemical abnormality.Cases: Three patients w...