Endocrine Abstracts

Introduction: Multiple endocrine neoplasia type 2B (MEN 2B) is an aggressive disorder characterized by medullary thyroid cancer (MTC) and pheochromocytoma. Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE is an effective new treatment for inoperable or metastatic neuroendocrine tumors (NETs). Hematologic problems, myelodysplastic syndrome or leukemia can be seen after alkylating agent and peptide receptor radionuclide therapy treatments. We present metastatic m...

BackgroundVascular endothelial growth factor (VEGF) has been implicated in angiogenesis of papillary thyroid carcinoma (PTC). As VEGF expression is increased in PTC and even in lymphocytic thyroiditis (LT), we hypothesized that VEGF may play a role in the development of PTC in patients with LT. In order to find an association between VEGF and these disorders, we examined both the tumoral and adjacent tissues of PTC patients with and without LT.<p cla...

Background and Aim: Humanin is a mitochondria-derived peptide (MDP) secreted in response to oxidative stress and linked to diverse cellular processes including inflammation and insulin resistance. Humanin has been shown to be downregulated in polycystic ovaries and exogenous humanin supplementation has attenuated insulin resistance and ovarian morphological abnormalities in a PCOS rat model. The aim of this study was to investigate the role of humanin in the pathophysiology of...

Introduction: Acromegaly is a disorder caused by excessive secretion of growth hormone, often due to pituitary masses. The first step in treatment is transsphenoidal surgery. Cabergoline, somatostatin receptor ligands or pegvisomant may be used in patients with an inadequate response after surgery. Finally, radiotherapy may be used in patients with inadequate response to medical treatment.Methods: In this retrospective study, data of 89 patients (59 fema...

BackgroundThe risk of cancer is relatively higher in Graves’ patients presenting simultaneously with thyroid nodules. Radioiodine (RAI) therapy recommended in intermediate-high risk differentiated thyroid carcinoma may be associated with worsening of a pre-existing Graves’ orbitopathy (GO) or developing a new onset. The impact of RAI therapy in patients with differentiated thyroid cancer on the course of a pre-exisiting GO has not been specific...

Introduction: Primary hyperparathyroidism (PHPT) is a prevalent endocrinologic disease and the most common cause of hypercalcemia. PHPT usually affects the elderly. PHPT younger than 40 years of age is less frequent. In young patients especially for ones younger than 30 years of age, screening for familial syndromes such as MEN 1 and MEN 2A is recommended. However, in most of the cases genetic tests are negative and evidence for other endocrine components are absent. Herein th...

Background and aim: In clinical populations, generic quality of life (QoL) questionnaires should be supplemented with disease-specific questionnaires, which may have higher sensitivity and clinical relevance. For the purpose of developing a comprehensive thyroid QoL questionnaire, we have evaluated the relative importance of various QoL aspects to thyroid patients.Methods: A list of problems (issues) related to thyroid diseases, previously identified thr...

Hashimoto’s thyroiditis (HT) is the most frequent thyroid disease in children, in areas of the world with sufficient iodine intake.Aim: To study the clinical features of HT in children at presentation.Material and method: We studied 99 children with HT, 76 (76.8%) girls and 23 (23.2%) boys, with mean chronological age 10.7±2.6 ys (3.2–15.6 ys). The diagnosis of HT was established from the high titers of antithyroid a...

Background and methodology: There are few data on changes in thyroxine requirement in the long-term follow-up of hypothyroid patients. We carried out a retrospective analysis to evaluate the long-term changes in thyroxine dose and its relationship with age, gender, thyroxine dose at registration and aetiology of hypothyroidism.Results: We identified 5,029 patients from our hospital based thyroid register with a minimum of 4 years follow-up (88% female, 7...

Background and methodology: In the long-term surveillance of treated hypothyroid patients, annual surveillance (with thyroid function testing) is widely recommended. This is largely based on consensus, as there is limited evidence to support this practice. Currently around 20,000 patients are registered in our hospital based thyroid register and the majority are on 18 monthly follow-up. We carried out a retrospective analysis to see if there is evidence to support increased fr...