Endocrine Abstracts

Background: Immune checkpoint inhibitors have not been shown to be active in well-differentiated NETs, with response rates <5%. Lenvatinib is a multitargeted TKI which targets VEGF and FGF receptors and has been reported to be effective in pancreatic and gastrointestinal NETs (40% and 18.5% ORR, respectively). The combination of antiangiogenic and checkpoint inhibitor therapies can be synergistic in other cancers. We therefore evaluated the combination of lenvatinib and pe...

Background: Pancreatic neuroendocrine neoplasms rarely secrete ACTH resulting in ectopic Cushing’s syndrome. Data are limited to case reports and very small series.Methods: Cases of ectopic Cushing’s syndrome were identified from a database of pancreatic NEN seen at the Moffitt Cancer Center between 1/2008 and 4/2022. Tumor characteristics, clinical signs and symptoms, therapies and outcomes were evaluated.Results: 13 pat...

Background: Somatostatin receptor (SSTR) expression in metastatic lung neuroendocrine (carcinoid) tumors has not been well-characterized using modern positron emission tomography (PET) imaging. Understanding degree and uniformity of SSTR expression is important to establish the role of SSTR targeted treatments, including peptide receptor radiotherapy (PRRT), in lung NETs.Methods: Retrospective review of medical records and imaging studies of patients wit...

Post-pituitary surgery hyponatraemia (HN, sodium <135 mmol/l) is relatively common and may result in prolonged hospitalisation. Herein we report a retrospective analysis of our experience in a tertiary institute. We conducted a retrospective case note review of 318 patients (M 54%, F 46%, mean age 58 years) 65.7% non-functioning adenoma (NFA), 10% somatotropinoma, 5% prolactinoma, 11% corticotropinoma (half were clinically silent), 8% craniopharyngioma, an...

A 45-year-old female presented with secondary amenorrhea. Since menarche, her period has been irregular, which she initially managed with oral pills, which were discontinued in 2009. Subsequently, she does have complete secondary amenorrhoea. She has hirsutism at the age of 20. Which was initially well controlled with oral contraceptive pills but has been getting worse over the years. Ferriman-Gallwey’s score was high. She also stated that her weight had been steadily inc...

Introduction: Checkpoint inhibitors (CPi) are finding a place in the treatment algorithm of an increasing number of cancers. Immune-related (ir) endocrinopathies are frequent side-effects. Diabetes mellitus (irDM) is infrequent, but often presents acutely and can be potentially life-threatening There are ˜60–70 cases characterising irDM in the literature. We describe 4 cases of irDM to add to the understanding of this condition. All four patients were undergoing trea...

Background: Type 2 diabetes (T2D) and obesity have been linked with sleeping disorders in general and obstructive sleep apnoea (OSA) in particular; both are highly prevalent amongst Emirati patients. However, little information is available in this population regarding the prevalence and symptomatology of OSA, its relationships with T2D and obesity, and its impact on health outcomes.Objectives: This study aims to investigate the risk of OSA based on the ...

Background: Acromegaly is rarely encountered in pregnancy and the lack of data for clinical outcomes limits the development of evidence-based guidelines. We present the case of a pregnancy in a 31-year-old woman with acromegaly due to a pituitary microadenoma.Clinical case: The patient underwent trans-sphenoidal hypophysectomy in 2015 at the age of 28, which was non-curative: post-operative IGF-1 was 533 mcg/l (72–259 mcg/l) (down from 894 mcg/l pre...

Introduction: Bardet–Biedl syndrome (BBS) is a rare genetic ciliopathy with a prevalence of 1 in 160,000 in Europeans and 1 in 13,500 in some Arab populations The primary clinical features of BBS include retinal dystrophy, obesity, postaxial polydactyly, renal dysfunction, learning difficulties, and hypogonadism. Traditionally, BBS is clinically diagnosed when a patient shows 4 primary featuresCase report: 17 year old male, single, worker, presented...

Introduction: Hashimoto’s encephalopathy is a neurological disorder of unknown cause associated with thyroid autoimmunity. It is easy to misdiagnose or overlook and the symptoms frequently lead to mistaken neurological diagnoses. The disease may present in two types – a sudden vasculitic type or a progressive subacute type associated to cognitive dysfunction, confusion and memory loss.Case report: A 34 year old male presented to our emergency d...