Endocrine Abstracts

Background: Pituitary adenomas are the most common intracranial neoplasm, with a slow-growing, locally invasive phenotype. Some result from syndromes or isolated germ-line mutations, while approximately 60% have no currently identified somatic mutation implicated in tumorigenesis. High throughput technologies such as microarray, RNA sequencing (RNAseq) and next-generation sequencing (NGS, incorporating whole genome- and exome sequencing) have recently been used to identify alt...

Introduction: Hypogonadism is linked to anaemia, sarcopenia and osteoporosis in men. Whereas secondary hypogonadism (SH) is biochemically indistinguishable from nongonadal illness, primary hypogonadism (PH) can be easily diagnosable by the identification of raised gonadotropins.Case Presentation: A 66-years old male with a background history of type 2 diabetes mellitus, arthritis, and hypertension was referred to the haematology services to investigate h...

Background: Hyponatraemia is a frequent finding in medical inpatients, where a comprehensive evaluation is warranted to establish the underlying mechanism and guide further management. Whilst the role of confounding medications, syndrome of inappropriate anti-diuretic hormone (SIADH), adrenal insufficiency and polydipsia is well-established as causative factors in the development of hyponatremia, the link between hypothyroidism and hyponatremia is controversial in the medical ...

Purpose: To study the features the structural and functional state of the myocardium and blood vessels in patients with diabetes mellitus and arterial hypertension depending on omentin level.Methods: A total of 65 patients (32 men and 33 women, mean age 51.6±5.2 years); 31- with type 2 diabetes and hypertension (group 1), 34 – with isolated arterial hypertension (group 2). Control group 20 healthy volunteers. We evaluated data transthoracic ech...

Primary Thyroid Lymphoma is rare comprising less than 5% among all thyroid malignancies. It is historically associated with Hashimotos thyroiditis. It typically presents as a rapidly enlarging, painless goitre resulting in compression symptoms. Thyroid ultrasound and FNA cytology, using flow cytometry and immunohistochemistry, remain the primary modalities to confirm the presence of lymphoma. Treatment depends on the immunohistology. The prognosis is subtype depended and is ge...

Aim: To define a basal Cortisol threshold that could potentially predict the outcome of short synacthen test (SST) and thus reduce the need for performing SST in patients with low clinical probability for adrenal insufficiency.Methods: We analysed SSTs done at our hospital in non-critically ill general medical and endocrine patients, who had abnormal 0900 h Cortisol levels (n=110, male-45, female-65) between January 2016 to March 2016. The SST w...

Introduction: Severe insulin resistance syndromes are rare syndromes characterized by clinical features like: acanthosis nigricans, ovarian hyper androgenism in post pubertal females: hirsuitism, oligomenorrhea and infertility.Major causes of severe insulin resistance are: i) genetic defects in insulin receptor like type A syndrome, or ii) autoimmune like antibodies to insulin receptor like in type B syndrome or antibodies to insulin itself, iii) congeni...

Background: Germline mutations in the aryl-hydrocarbon receptor interacting protein (AIP) gene have been implicated in the tumorigenesis of patients with familial isolated pituitary adenoma (FIPA). Around 25% of FIPA patients have an identified AIP mutation; in the remainder of FIPA patients, molecular mechanisms involved in pituitary tumorigenesis have yet to be elucidated.Aims: To identify the genes and molecular mechanisms involved i...

The gut microbiota contributes to postnatal development and maturation by influencing barrier functions of the intestinal wall, the development of the immune system, and the utilisation of nutrients. Recent studies have also implicated a role in the prenatal period since the maternal gut microbiota is altered during pregnancy with a potential role in the regulation of glucose homeostasis and protection against preterm birth. Using as a model system germ-free mice that have nev...

Bisphenol A (BPA) is a byproduct of polycarbonate plastic widely present in food containers. BPA is historically a known endocrine disruptor and due to its oestrogen agonist activity, BPA consumption is associated with hypothyroidism and reproductive disorder. Recent studies have shown that oestrogen antagonised GH actions. Since BPA has oestrogen agonist activity, the effect of BPA exposure on GH activity has not yet been investigated.Aim: To study the ...