Endocrine Abstracts

Diabetes mellitus is life threatening endocrine disorder with high morbidity and mortality, which is featured by persistent high blood glucose levels due to defect in the insulin secretion, insulin action or both. Extreme high blood glucose levels associated with diabetes leads to various organ dysfunction particularly nervous system, eye, cardiovascular system, and kidney. Kaempferol is a dietary bioflavonoid that is common in plant-derived foods and used in traditional medic...

Background: Congenital hyperinsulinism (CHI) is one of the commonest causes of recurrent hypoglycaemia due to excess production of insulin in infancy and results in neurological impairment in a third to a half of patients. The treatment of CHI is often complex and complicated by side effects; the medium-term effects of such treatment are not known.Aim: To describe five year clinical outcomes in a cohort of infants with CHI.Methods:...

Background and aim: Improving the quality of life is one of the main goals of treating diabetic patients in addition to manage glycaemic control and diabetes complications. The study aim was to assess and compare the quality of life among Austrian patients with type 1 and type 2 diabetes mellitus using the German version of the World Health Organization Quality of Life-BREF instrument (WHOQOL-BREF).Methods and Materials: This was an observational study t...

Purpose: The use of anabolic androgenic steroids (AAS) to improve fitness and increase muscle mass is widespread among athletes. Information regarding self-administered AAS used to enhance athletic performance or improve physical appearance is sparse and poorly documented in Saudi Arabia. The purpose of this study is to investigate the prevalence and motivation of AAS use and knowledge of its adverse effects among fitness centres visitors in Eastern Province, Saudi Arabia....

Introduction: Hyponatremia is common in hospitalised patients and can be due to a number of aetiologies. Investigations and management are often quite varied.Aims: To find out the prevalence, aetiology, investigations and management of hyponatremia in our hospitalised patients over a 2 week period (1 May and 15 May 2011).Methods: Case notes and electronic data assessment of all patients admitted with sodium level <130 mmol/l.</...

Background: We have recently shown that consumption of green coffee bean extract rich in chlorogenic acid reduces blood pressure and urinary free cortisol levels1. Increased 11β HSD1 (Hydroxysteroid dehydrogenase type1) activity is implicated in the development of obesity, cardiovascular disease and diabetes. The aim of this study was to compare the effects of consuming green (GC) and black (BC) coffees on cardiovascular, anthropometrical markers and urinary free glucocor...

Background and objectives: Identification of metabolic syndrome (MS) is important for the strategy to reduce the prevalence of NIDDM. The latest IDF consensus definition emphasizes waist circumference as the central criteria, while the earlier ATP III definition gives equal importance to different risk factors. In absence of local data on definition of central obesity, it might be inappropriate to use the IDF definition. Therefore, it is aimed to investigate the prevalence of ...

Background and aim: Antioxidants have been postulated to exert beneficial effects on cardiovascular and neurodegenerative diseases by neutralizing reactive oxygen species (ROS). Exercise and metabolic processes are known to produce ROS. Pomegranates are rich in polyphenolic antioxidants. The aim of this study is to investigate the effects of pomegranate pure juice consumption on blood pressure, lipid peroxidation and urinary glucocorticoid levels before and after a moderate ex...

Introduction: Sarcopenic obesity prevails with ageing, encompassing excess weight gains and muscle mass or strength losses. Free fatty acids and proinflammatory cytokines are elevated in obese adults. Palmitate decreases the anabolic effects of IGF signalling, while EPA elicits anti-inflammatory activities.We aimed to examine the effects of palmitate and EPA on TNF-α/IGF1 interactions in established models of skeletal muscle cell loss.<p class="...

Inflamed ageing is associated with reduced muscle mass and increased susceptibility to TNF-induced muscle protein degradation. We therefore aimed to elucidate mechanisms supporting reduced hypertrophy and increased atrophy of skeletal myoblasts. C2 myoblasts display diminished differentiation and increased susceptibility to TNF-α-induced apoptosis versus daughter C2C12 cells, providing us with relevant models. C2 and C2</su...