Endocrine Abstracts

Aim: The aim of this retrospective study was to evaluate the diagnostic significance of presurgical thyroid ultrasound in comparison with FNAC of thyroid nodules and their contribution in detecting thyroid cancer.Patients and methods: We retrospectively studied the files of 118 thyroid cancer patients, 18 men (15.2%) and 100 women (84.8%), who underwent thyroidectomy from January 2013 until December 2016, in the Department of Surgical Oncology of Theagen...

Background: Early carbohydrate metabolism disorders (ECMDs) and diabetes mellitus (DM) are frequently associated with endogenous hypercortisolism (EG). Prevalence of secondary (sDM) in these cases are poorly investigated.Aim: We aimed to assess the prevalence of ECMDs and DM in patients with EG (pituitary-dependent Cushing disease (CD)) and adrenal-dependent Cushing (AC) and ACTH-ectopic syndrome (ACTHs) depending on gender and age.<p class="abstext"...

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

The glucagon-like peptide-1 receptor (GLP-1R) is a G protein-coupled receptor (GPCR) expressed in various tissues such as brain and pancreas where it contributes to the regulation of energy expenditure and metabolism. Due to its involvement in glucose-dependent release of insulin from pancreatic beta cells, the GLP-1R has become a blockbuster target for the treatment of type 2 diabetes. Despite this, debate still exists about the exact distribution of the GLP-1R throughout the...

Introduction: Empty sella syndrome (EES) is a condition often discovered incidentally, where the sella turcica, the structure containing the pituitary gland, appears to be empty. Patients either remain asymptomatic or, rarely, manifest signs of declined pituitary function. Patients experiencing hypopituitarism are offered hormonal replacement. Autopsy studies estimated a 5% EES prevalence among healthy individuals.Case report: A 68-year-old post-menopaus...

Introduction: Cushing’s syndrome is a rare (0.004%) hormonal disorder, which develops due to hypercortisolaemia. Cushing’s disease refers to a corticothroph cell pituitary tumour overproducing ACTH, which induces abnormally increased cortisol production from the adrenal glands. Cushing’s disease is a causative factor of osteoporosis, hypertension, glucose intolerance and dyslipidaemia.Case report: A 50-year old woman was referred to our de...

Background: Vitamin D receptor (VDR) and progesterone receptor (PR) expression have been described before in papillary thyroid carcinoma but data regarding association of this expression with tumour histological characteristics are scarce.Materials and methods: Formalin-fixed, paraffin-embedded specimens from adult patients with papillary thyroid carcinoma (PTC), who underwent total thyroidectomy from 2009 to September 2012 were retrieved. Data regarding...

Introduction: Patient’s nutrition is generally considered to be the main cause of the accumulation of excess body weight. However, this accumulation can be mitigated by treatment involving drugs with a central mechanism of action. By using functional Magnetic Resonance Imaging (fMRI) we can meliorate our understanding of the organization of neuronal networks responsible for eating behavior, and see how they respond to the mechanisms of action of sibutramine in the treatm...

Introduction: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Patients and Methods: This cross-sectional study included 420 ...

Introduction: The role of thyroid hormones is important in testicular development and function (involvement in Sertoli cell proliferation and functional maturation control and postnatally in Leydig cell differentiation and steroidogenesis). Additionally, thyroid hormone receptors are found in testicular cells throughout development and in adulthood. Our aim was to study thyroid hormone effects on testicular function.Materials and methods: We retrospectiv...