Endocrine Abstracts

Introduction: Exposure to air pollution and in particular to nitrogen dioxide (NO2) or particulate pollutants less than 2.5 µm (PM2.5) or 10 µm (PM10) in diameter has been linked to thyroid (dys)function in pregnant women. The environmental degradation that has occurred in recent years in the region of Athens led us to a local study of air pollution against thyroid function in pregnant women in Athens. We hypothesized that there may be a dose-effect relati...

Introduction: The polycystic ovary syndrome (PCOS) is a common and complex disease without a clear pattern of inheritance. There is evidence that PCOS is affected by both genetic and environmental factors, but there is no single and unambiguous explanation for its pathogenesis. Anti-Müllerian-inhibiting hormone (AMH) has an inhibitory effect on FSH-stimulated follicle growth and it has also been shown that serum AMH levels are higher in women with PCOS than in normovulato...

Introduction: Although data on the association of primary hyperparathyroidism (pHPT) with cardiovascular disease are accumulating, there is still controversy on this issue. Moreover, possible associations of aortic stiffness and central aortic pressures with pHPT and associated effective molecules have not been addressed.Methods: Seventy patients with pHPT were consecutively recruited from the outpatients’ clinic of an academic department of endocri...

Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disorder characterized by the presence of endocrine and nonendocrine tumors. Until recently, more than 450 different germline mutations have been reported in MEN1 patients involving frameshift deletions, insertions, as well as nonsense mutations.Aim: To report a novel mutation in MEN1 gene in a young female with persisting primary hyperparathyroidism.<p class="ab...

The management of metastatic differentiated thyroid carcinoma included until recently the use of therapeutic 131I, radiotherapy and in specific cases chemotherapy. However, recently new agents entered in the management of differentiated metastatic thyroid carcinoma which aim at specific cell receptors and inhibit the growth of the carcinoma in a specific and targeted way.The aim was to present the experience of the use of the receptor tyrosine...

Differentiated thyroid carcinoma represents a small percentage of human carcinomas. However, it is the commonest endocrine neoplasm and if diagnosed and treated properly does not affect the long-term survival of the patients.Aim: The aim was to study differentiated thyroid carcinoma affecting young adults.Patients and methods: All patients presenting with thyroid carcinoma to the department from 01.01.2002 to 31.12.2008 were review...

Medullary thyroid carcinoma is an uncommon malignancy of hereditary and sporadic presentation. Mutations in the RET-protooncogene are involved in the pathogenesis of >50% of the sporadic cases. Currently, there is no effective treatment for metastatic medullary thyroid carcinoma. The aim was to present a case of metastatic medullary thyroid carcinoma that was treated by the administration of sorafenib, a multiple kinase inhibitor.A patient, female ag...

Objective: Establishment of rodent in vitro cell systems for the extension of the functional data about the recently cloned neuroendocrine marker secretagogin.Methods: 1. DNA-cloning; 2. Antibody generation; 3. Immunoblotting and Immunohistochemistry; 4. Cell-transfection; 5. Luciferase Reporter Assays; 6. ELISA.Results: 1. We characterized the rat homologue of human secretagogin (rat secretagogin) and demonstrated the homol...

Introduction: Bariatric surgery is a revolutionary method for the treatment of morbid obesity. It is effective as far as weight control is concerned, for the prevention and treatment of diabetes mellitus and the metabolic syndrome. However, bariatric surgery may be accompanied by adverse effects if postoperatively dietary instructions are not adhered to.Aim: The aim was to present a case of a patient who underwent sleeve gastrectomy for the treatment of ...

IntroductionRecent evidence suggests a possible link between prediabetes and lower density in postmenopausal populations. Moreover, earlier data suggest a link between diagnosis of diabetes and lower levels of bone density in women after the menopausal transition. We aimed to evaluate the possible association between insulin resistance and a diagnosis of lumbar or hip osteoporosis and/or prevalent fractures of the lumbar spine. Met...