Endocrine Abstracts

Objective: Incidence of concomitant thyroid cancer and Hashimoto thyroiditis (HT) is found to be 0.3–58% in different series. In this study, we aimed to find out HT incidence in thyroid cancer patients in our clinic and we tried to determine ultasonographic and histopathologic features of tumor in these patients.Method: About 165 patients diagnosed with thyroid carcinoma between 2005 and 2008 were included in the study. Patients with Graves’s d...

Objective: Role of thyroid stimulating hormone (TSH) in thyroid oncogenesis is not clear. There are few trials about relationship of TSH, thyroid hormones and autoantibodies with malignancy. We aimed to investigate thyroid function tests and malignancy in patients evaluated in thyroid disease council and decided to be managed with thyroidectomy.Method: About 272 patients were included in the study. Hyperthyroid and hypothyroid patients, patients on <smal...

Objective: Fine needle aspiration biopsy (FNAB) is a reliable and safe method to distinguish benign and malignant thyroid nodules. FNAB has two major limitations: nondiagnostic and suspicious cytology results. There is uncertainty about clinical approach to the nondiagnostic FNAB in thyroid nodules. Our aim was to evaluate the ratio and reasons of nondiagnostic results, and the ratio of malignancy in these nodules.Method: About 2082 patients and 3404 nod...

Introduction: The incidence, cell origin, histopathologic features and prognosis of papillary and medullary carcinoma are considered to be completely different. Simultaneous occurrence of medullary and papillary thyroid carcinoma in the same patient is rare. Here, we present a patient with synchronous medullary thyroid carcinoma and papillary microcarcinoma occurring in a thyroid with chronic lymphocytic thyroiditis.Case: A 47 years old woman with no his...

Objective: Pendred syndrome is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter, and a partial defect in iodide organification. Pendred syndrome is caused by mutations in the SLC26A4 gene. Here, we report a patient with pendred syndrome and papillary thyroid carcinoma.Case report: A 19-year-old man admitted to our clinic with swelling in his neck. Congenital hypothyroidism was diagnosed at the age of one. His twin broth...

Background: Ca 19-9 is a tumor-associated antigen. In this study, we aimed to compare Ca 19-9 levels in type 2 diabetes mellitus (DM) patients and healthy control group.Method: Two hundred and fifteen type 2 DM patients (82 male and 133 female) and 209 healthy control group (79 male, 130 female) age, sex and body mass index(BMI) matched were included in the study. Duration of diabetes, HbA1c and presence of complications were analyzed. Cases with high se...

Objective: Mean platelet volume (MPV), is an indicator of platelet sizes, and an indirect marker of platelet function and activity. In this study, we aimed to evaluate MPV in patients with acromegaly, and to investigate the effects of octreotide long acting repeatable (LAR) on MPV after 6-month therapy.Methods: Data of 25 patients with acromegaly (16 women; 9 men; mean age, 43.8±13.5 years) included in the study were searched retrospectively. The da...

Primary thyroid lymphoma is an uncommon malignancy; it accounts for <2% of all extranodal lymphomas and <5% of all thyroid malignancies.Case report: A 52-year-old male patient who was known to have a nodule in his thyroid gland for many years presented with instantaneous enlargement of his existing nodule and with appearance of ipsilateral cervical lymphadenopathy. On thyroid ultrasonography, a giant nodule of 38.4×31.6×45.5 mm size, an...

Introduction: Bisphosphonates are the most commonly used drugs for the treatment of osteoporosis and have been shown to improve bone mineral density and reduce fractures. However, approximately a decade ago, atypical femoral shaft fractures were found to be a rare complication of bisphosphonate treatment. Atypical Femoral Fractures (AFF) represent fractures located between the lesser trochanter and the supracondylar flare of a femur. An increasing pool of evidence supports the...

Introduction: Parathyroid carcinoma (PC) mediated hypercalcemia is often severe and more resistant to medical treatment. 18F-Fluorocholine PET/CT is a new technique used for determining the localization of parathyroid lesions. Denosumab, novel antiresorbtive agent, has been shown to have a useful role in hypercalcemia treatment. We report a male patient in long-term follow-up of PC who had refractory hypercalcemia due to pulmonary metastases revealed with 18-Fluorocholine PET/...