Endocrine Abstracts

Introduction: Nodular thyroid pathology is very frequent. Its exploration requires a clinico-biological evaluation, a cervical ultrasound to look for the ultrasound criteria of malignancy allowing to classify the thyroid nodules according to the EU-TIRADS classification in order to orientate the diagnosis and to indicate the Fine needle aspiration, to finally allow a targeted management. The aim of our study is to investigate the correlation between the EU-TIRADS classificatio...

Background: In the UK, NICE guidelines for familial hypercholesterolaemia (FH) recommend a greater than 50% reduction in low-density lipoprotein-cholesterol (LDL-C) as the therapeutic target. However, despite the availability of a range of lipid lowering medication, this target is often difficult to achieve and, more importantly, maintain life-long. Understanding factors that affect LDL-C target achievement is key to reducing cardiovascular disease (CVD) risk. Currently, there...

Background: Cardiovascular disease (CVD) risk in familial hypercholesterolaemia (FH) is driven by cumulative exposure to high low-density lipoprotein cholesterol (LDL-C) levels. Previously, LDL-C burden has been loosely approximated using the cholesterol year score (CYS) based on two LDL-C readings only. We aimed to determine whether a more sophisticated LDL-C burden score based on serial LDL-C measurements, could more accurately predict major atherosclerotic cardiovascular ev...

Background: Osteoporosis (OP) is underdiagnosed and frequently left untreated. CT derived bone mineral density (BMD) and identification of vertebral compression fracture (VCF) on CT done for another indication are 2 new artificial intelligence (AI) based techniques for opportunistic diagnosis of OP. Our aim was to assess the clinical impact of opportunistic diagnosis of OPMethods: This retrospective study included men and women over age 50, insured by Cl...

Objective: Incidence of paediatric type 2 diabetes appears to be increasing. We describe our cohort of paediatric type 2 diabetes at Barts Health NHS Trust in East London (UK) over the period 2008-2018 to gain insight in incidence, complications and outcomes.Methods: Retrospective cohort study. Data collection from Twinkle (electronic database for diabetes) and paper notes.Results: Fourty patients (25 female) were diagnosed with T2...

Introduction: Brown tumors or osteitis fibrosa cystica are benign bone tumors complicating uncontrolled primary or secondary hyperparathyroidism. They may behave aggressively and can be destructive. Their osteolytic aspect may be misinterpreted as skeletal metastases.Methods: A 37-year-old female patient with chronic renal failure on dialysis, presented with pain and swelling of her left knee for 10 days, with no associated trauma. She gave history of tu...

Introduction: Antithyroid drugs (ATD) are usually the first-line treatment for Graves’ disease (GD). It represents an effective treatment with good compliance. This therapeutic modality can be the cause of adverse effects including hematological, cutaneous and hepatic complications. The aim of our study is to evaluate the efficacy of ATD as well as its tolerance in patients with GD.Methods: It is a retrospective study that included 76 patients, with...

We have previously described how signaling responses for the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR that plays key roles in metabolic regulation and is a prime type 2 diabetes (T2D) target, are modulated by intracellular membrane trafficking. We have also recently shown that binding to the therapeutic GLP-1R agonist exendin-4 (Exenatide) triggers increased clustering and segregation of biologically active GLP-1Rs into cholesterol-rich plasma membrane nanodom...

Introduction: Addisson’s disease is a rare endocrine disorder; that continues to be a diagnostic challenge in the 21st century; mainly due to the slow and non specific progression of symptoms. We report the case of a 45-year-old woman who was admitted with acute adrenal insufficiency discovered in the context of a severe hyperkalemia.Case report: A 45-year-old woman was admitted in our institution with a history of extreme weakness and vomiting. On ...

Introduction: Primary hyperparathyroidism is due to excessive and inappropriate production of parathyroid hormone. The treatment is essentially surgical. The objective of this work is to specify the clinical and paraclinical characteristics of this pathology and specify the methods of management.Methods: A descriptive retrospective study conducted at the Department of Endocrinology Diabetology and Metabolic Diseases of the University Hospital of Casablan...