Endocrine Abstracts

Introduction: Hypoparathyroidism treatment is aimed to achieve a serum calcium at the lower limit of normal providing symptom resolution and preventing complications such as urolithiasis and renal impairment. Milk-alkali syndrome (MAS) incidence has been gradually rising associated with the increase of calcium carbonate and vitamin D supplementation. The classic triad is characterized by metabolic alkalosis, hypercalcemia and renal failure.Case report: A...

Background: Current guidance for the management of macroprolactinomas recommends full pituitary profile at baseline and subsequently only if symptomatic. Pituitary adenomas that co-secrete growth hormone and prolactin at presentation are well-recognised. Case reports of acromegaly after prolactinoma treatment are associated with symptomatic acromegaly. We present two patients with asymptomatic acromegaly years after diagnosis of macroprolactinoma.Patient...

Introduction: Precocious puberty in boys is the development of secondary sexual characteristics before 9 years of age. Peripheral precocious puberty (PPP), as opposed to central precocious puberty (CPP), is caused by autonomous secretion of androgens or human chorionic gonadotropin (hCG). Testicular volume, penis size, growth velocity, gonadotropin and androgen levels, and bone age readings aid in diagnosing precocious puberty and in identifying its cause. Distinguishing CPP f...

Introduction: We evaluated glycemia and the iron status in patients with NT-SCD and 6 patients with TD- SCD by measuring serum ferritin level (SF), liver iron content (LIC), alanine transferase (ALT) and fasting blood glucose (FBG) over 5 years of follow up.Results: At the initial assessment, 16 adults with (age: 33±14 years), and six of TD-SCD (n=6, age =25±10 years) were studied. 6/16 of NT-SCD had SF > 500 μg/l, and 5/16 ha...

Homocystinuria is a rare autosomal recessive disorder of the transsulfuration or methylation pathway in methionine metabolism.We present a case of a 25 years old female, who presented with rapid onset loss of vision in both eyes and short-sightedness. She had a background of well-controlled epilepsy, normal mental and physical development. She had no family history of Marfan’s syndrome.On examinatio...

Homocystinuria is a rare autosomal recessive disorder of the transsulfuration or methylation pathway in methionine metabolism.We present a case of a 25 years old female, who presented with rapid onset loss of vision in both eyes and short-sightedness. She had a background of well-controlled epilepsy, normal mental and physical development. She had no family history of Marfan’s syndrome.On examinatio...

Introduction: Interleukine-4 (IL-4) a T-helper type 2 cytokine (Th2), has been implicated in the pathogenesis of autoimmune thyroid diseases (AITD). However, the role of IL-4 in Hashimoto’s thyroiditis (HT) pathogenesis remains controversial. In this study, we investigated whether a constitutive IL-4 overexpression in the thyroid tissue (Thyr-IL4) could influence the development of thyroiditis in resistant (C57BL/6) or susceptible (NOD.H2h4) mouse strains.<...

Introduction: Diagnosis of Cushing Syndrome (CS) is challenging due to its various non-specific symptoms, and multiple endogenous and exogenous causes. The incidence of endogenous CS is rare and estimated at 2 to 3 cases per million inhabitants per year in Europe (1). Primary bilateral macronodular adrenal hyperplasia (PBMAH) is an uncommon cause of endogenous ACTH-independent CS. It is a benign condition, characterized by the presence of bilateral macronodules (>1 cm), an...

Introduction: Premature ovarian insufficiency (POI) is a rare cause of primary amenorrhea (1,2). We report a 16-year-old girl with normal secondary sexual characteristics, but no menses due to an autoimmune POI and associated with autoimmune gastritis. This is the first report of such constellation in an adolescent – both conditions separately already being rare in the pediatric population.Case presentation: A 16-year-old girl was referred to our de...

Introduction: Autoimmune disease is a rare event occurring after remission of Cushing’s syndrome. We report on the appearance of new onset vitiligo in a patient treated for Cushing disease due to a an invasive pituitary adenoma, after bilateral adrenalectomy.Case report: A 64-year-old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing&#146...