Endocrine Abstracts

The aim of this retrospective study was to compare the long-term evolution of adrenal insufficiency (AI) due to bilateral adrenal surgery (S) or medical cause (M).Seventy AI patients (mean age 41±16 years; 60% female, similar in both groups) were followed during a mean 6-year period (2–16); 38 were AI after bilateral adrenalectomy (60% Cushing), 32 AI of medical origin (62% polyglandular autoimmune syndrome). BMI, blood pressure (BP), fasting b...

Purpose: Aster spathulifolius Maxim is one of plants of chrysanthemum, which has shown an anti-obesity activity in diet induced mice model. We performed clinical trial for evaluating the anti-obesity efficacy and safety of Aster spathulifolius Maxim extract on obese human.Methods: This study was randomised, double-blind, placebo-controlled clinical trial in Korea. A total of 41 obese subjects (BMI 25–30 kg/m2) aged ≥20 years were ra...

Background: Locoregional nodal metastases are the first step of tumor spread in MTC and have been shown to be a prognostic factor for survival. Neither palpation nor neck ultrasound can estimate nodal staging accurately.Aim: To identify predictive factors for LNI in MTC through a retrospective study on 142 consecutive patients operated in Lille University Hospital between 1995 and 2010.Methods: Analyses were carried on 54 patients ...

Papillary thyroid carcinoma (PTC) is the most common malignancy originating from the thyroid gland. Although occurring predominantly as a sporadic disease, it may be associated with rare inherited circumstances such as familial adenomatous polyposis (FAP) FAP is an autosomal dominantly inherited cancer predisposition syndrome characterized by the progressive development of colorectal carcinoma. Most of available data report accompanying thyroid carcinoma in no more than 1&#150...

The biological diagnosis of pheochromocytoma (P) and/or paraganglioma (Pgg) relies on the identification of excessive secretion of the metanephrines. Chomogranin A (CgA) is a general indicator of neuroendocrine tumours that is highly expressed in P and correlate with tumour mass and secretory activity. The CgA test could be indicated as a useful test in patients with false positive metanephrines results. The aim of our prospective bi-centre study, is to evaluate the performanc...

Sixty patients with traumatic brain injury are newly diagnosed every year in our island, particularly in patients with addictive behaviours. In France, it is the 4th rank of health expenses, as a major issue of public health care. In order to perform a first endocrine assessment, we performed a pilot study to diagnose traumatic brain injury induced hypopituitarism, assessed at least 6 months after injury, in moderate to severe traumatic brain injuries patients, hospitalized in...

Methods: In a prospective longitudinal study, 156 determinations of osteocalcine (OC) as a marker of bone formation, and of C-telopeptide of type-1 collagene (CTX and ICTP) as markers of bone resorption were performed in 103 patients {20 men (median age 50 years), 83 females (median age 56 years – 58% with age >50 years)} treated with suppressive levothyroxine therapy for DTC. Bone mineral density (BMD) of the hip was measured by dual X-ray absorpti...

Pheochromocytomas are neuroendocrine tumors able to synthesise cathecholamines as well as to metabolise them in metanephrines (NM,M). We assayed Adrenaline, NorAdrenaline, Dopamine and metanephrines in serum (p) and urine (u), and the chromogranin A. We measured 11 parameters (Ap, Au, NAp, NAu, Du, MNp, MNu, Mp, Mp, 3Metu, CgA). Catecholamines and metanephrines were performed using HPLC with electrochemical detection, and CgA with an immunometric as...

Much controversy persists over aggressiveness of oncocytic thyroid carcinoma (OTC) and its optimal treatment. The study purpose was to determine prognostic factors for persistent or recurrent disease (PRD) and discuss therapeutic directions.We reviewed the medical records of 81 consecutive patients with OTC among a total of 1729 (4.7%) epithelial thyroid cancers, operated from 1983 to 2003 in our center. Follow-up information was updated. Age ranged from...

Background and aims: It is known that unilateral adrenalectomy as treatment for autonomous secreting adrenal cortex adenomas effectively reduces cardiometabolic risk. Non-autonomous secreting adenomas are not expected to increase cardiometabolic risk, but this has not been thoroughly explored.We evaluated the blood pressure and glycemic profile before and after unilateral adrenalectomy for both autonomous and non-autonomous secreting adrenal cortex adenomas.<p class="abste...