Endocrine Abstracts

Introduction: The use of Continuous Subcutaneous Insulin Infusion (CSII) is expected to improve glycemic control and to reduce hypoglycemia events. However, long-term beneficial results in glucose control are not always observed. We evaluated long-time glucose control and severe hypoglycemias in type 1 diabetic patients using CSII, without continuous glucose monitoring.Patients and methods: This was a retrospective study of adult type 1 diabetic patients...

Disruption of circadian regulation could trigger and exacerbate obesity, type 2 diabetes mellitus, and cardiovascular disease. Experiments on rats proved that the deleterious effects of chronodisruption are extremely severe, especially during early developmental stages. Only part of them could be prevented by maternal melatonin administration, suggesting that other pathophysiological mechanisms may be involved. To investigate the role of other mechanisms that might contribute ...

Background: In the previous study, it was demonstrated that pancreatic steatosis was significantly associated with subclinical atherosclerosis in patients with non-obese T2DM. As the result, it was suggested that pancreatic steatosis might be related to macrovascular complication of T2DM. However, the association of pancreatic steatosis on microvascular complication of T2DM has been unknown.Objective: This study aimed to investigate the relation between ...

Introduction: The frequency of thyroid surgery for suspected malignancy but postoperative resulted with benign pathology tends to increase in the worldwide. Therefore, additional preoperative markers are needed to prevent excessive surgery. Neopterin is a new molecule secreted by monocytes and macrophages and indicates the activation of cellular immunity. Therefore it can be used as a marker of immune activation. We aimed to evaluate the diagnostic value of serum neopterin lev...

The use of gallium-68 (68Ga) is rapidly expanding with new applications arising almost every week. Therefore, the global availability of this nuclide is a critical issue. 68Ga is currently sourced from commercial 68Ge/68Ga generators but their production is limited by the availability of the parent nuclide 68Ge. Alternatively, the use of a 68Zn salt solution in a liquid target has been proposed [1] [2]. With thi...

The aim of this retrospective study was to compare the long-term metabolic evolution of a cohort of patients treated for adrenal insufficiency (AI), and the best biological parameters of a good balance.Seventy patients with AI (mean age 41 years (±16); 60% female) were followed during a median 6-year period (2–16 years): 38 after bilateral adrenalectomy (60% Cushing) and 32 after AI of medical origin (62% polyglandular autoimmune syndrome). BMI...

Background: Adherence to recommended guideline for monitoring of glucose control and screening of diabetic complications has been demonstrated to prevent the chronic complications of diabetes. In Korea, the clinical audit for quality of diabetes care has been started in 2011. The aim of this study is to investigate the change of adherence to a process quality-of-care-indicator in diabetes after the initiation of audit in Korea.Methods: This retrospective...

Background: Regular monitoring of glucose control and screening of diabetic complication and adherence to treatment are cornerstones for prevention of chronic diabetic complications. The aim of this study is to investigate the association between quality of diabetes care and the development of chronic diabetes complications.Methods: This retrospective study was performed using the national health insurance claims database from the Health Insurance Review...

Background: TSH suppression therapy has been associated with hip and vertebral fracture. However, the relationship between TSH suppression and bone mineral density (BMD) remains controversial. The aim of this study was to evaluate the effect of TSH suppression therapy on cortical bone geometry in differentiated thyroid cancer (DTC) patients.Methods: This study included 122 subjects (19 men, 27 premenopausal women, and 75 postmenopausal women) who have be...

Introduction: Cardiovascular changes are rare but life-threatening consequences of primary hyperparathyroidism.Case report: A 53-year-old man, with past and family history of peptic ulcer, presenting with coronary heart disease and ischemic and dilated cardiomyopathy, treated with cardiac resynchronization. He was admitted to the emergency room due to sustained monomorphic ventricular tachycardia (MVT). Laboratory tests revealed primary hyperparathyroidi...