Endocrine Abstracts

Introduction: X-linked adrenoleukodystrophy (X-ALD) is caused by a mutation in the ABCD1 gene, which encodes for a peroxisomal very long chain fatty acid (VLCFA) transporter. Clinically, X-ALD can present a wide spectrum of phenotypes, being the most frequent Adrenomyeloneuropathy, with ataxia, spastic paraparesis, sexual and sphincter dysfunction. Adrenocortical insufficiency (AI) occurs mainly in paediatric age and it can be the first manifestation of the disease in some cas...

Introduction: Pheochromocytoma and most abdominal paraganglioma (PPGL) can secrete catecholamines. In vitro and in vivo, catecholamines modulate bone remodeling by stimulating bone resorption. In patients with PPGL, four studies have previously demonstrated an increase of biological markers of bone resorption, a decreased of bone density and a higher prevalence of vertebral fractures. We report two patients with malignant abdominal secreting paraganglioma pre...

Parathyroid hormone(PTH) is a peptide hormone that regulates ionized calcium. Primary hyperparathyroidism, in which the bone-building-destruction balance is disturbed, is due to the uncontrolled secretion of parathormone. The systemic inflammation index (SSI) is a variable that has been validated in studies aimed at evaluating the inflammation that has been frequently mentioned recently. The disruption of this bone-making destruction process affects the inflammatory process in...

Background: Anemia is a common finding in patients with diabetes mellitus which increases the progress of the diabetic complications. There are several factors which cause anemia out of renal failure in diabetics. In this study, we aimed to investigate the frequency of anemia and factors that decreases hgb levels in diabetic patientsMethods: This retrospective study includes 207 diabetic patients that were hospitalized between january 2019 and january 20...

Obesity leads to low-grade inflammation, and high-fat diet is one of the major causes. On the other hand, menopause can aggravate it by promoting food intake alterations, and metabolic and endocrine adaptations. Thus, we used ovariectomized rats fed with high-fat diet to evaluate changes on the tissue inflammatory state. Forty days-old female Wistar rats were fed with: a hyperlipidic diet enriched with lard – H-group; or chow diet – C-group; for 30 days. After this p...

Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.Results: The treatment of ALA with or wit...

Neuroactive steroids synthesized in the brain, referred to as neurosteroids, have gained particular attention as they appear to be involved in the modulation of various neuroendocrine, behavioral and pathophysiological processes. Thus, the distribution of steroidogenic enzymes and the identification of the biochemical pathways leading to neurosteroid formation have now been almost completely elucidated in various groups of vertebrates. In contrast however, the neuronal mechani...

Introduction: Hypophosphatemic rickets comprehends a group of hereditary diseases characterized by hypophosphatemia and defective bone mineralization. The most common form is X-linked, with a prevalence of 1:20.000.Objectives: Describe the follow up of patients with hypophosphatemic rickets in a public center in Brazil.Methods: Patients with hypophosphatemic rickets were selected from a database of Endocrinology and Metabolism Serv...

Purpose: Bone metastases (BM) are frequent in differentiated thyroid cancer (DTC). These patients may present skeletal-related events (SRE), the leading cause of DTC-related morbidity. We aimed to evaluate the clinical features, treatment approaches, and outcomes including overall survival (OS) of DTC patients with BM complicated by SRE and their evolution over time.Methods: 178 consecutive DTC patients harbouring BM were enrolled in this retrospective s...

Introduction: Guidelines recommend using first-line tests, including 24-hour urine-free cortisol (UFC), overnight 1-mg dexamethasone suppression test (DST), and late-night salivary cortisol (LNSC) for the positive diagnosis of hypercortisolism. Unfortunately, LNSC access is constrained in certain institutions, requiring, as an alternative, hospitalization for midnight plasmatic cortisol (F00h) measurement. This study explores the diagnostic potential of afternoon plasma cortis...