Searchable abstracts of presentations at key conferences in endocrinology

ea0063ep84 | Interdisciplinary endocrinology | ECE2019

Osteoporosis issues & complementary Indian medicine: three years experiences in Asian population

Pal S , Gupta G , Roy T

Issues: No specific centre in asia for Osteoporosis patients treatment/rehabilitation. We used locally available Complementary Indian Medicines [CAM] for providing home based care in rural/tribal areas.Aims: To provide CAM to poor patients in collaboration with Traditional-faith-hearers. Evaluated cost-efficacy of CAM & response of pain of fractures to CAM alongside analgesics.Methods: This was a cross sectional, observational ...

ea0031p368 | Thyroid | SFEBES2013

Managing Graves' disease: management involving endocrine nurse led service: experience from DGH

Aziz Aftab , Cox Sue , Dyer Rob G.

Graves’ disease is an autoimmune condition predominantly affecting middle aged women. It can be difficult to manage and consumes a lot of medical time and resources.In Torbay Hospital, we introduced endocrine nurse specialist (ENS) follow up service to reduce medical burden. This has shifted the work-load of patient care but on the other hand, has resulted in identification of great need for support and increased nurse time.We...

ea0029s26.3 | TSH Receptor | ICEECE2012

Structure and function of TSH receptor

Biebermann H. , Kleinau G. , Gruters A. , Krude H.

The Thyrotropin receptor (TSHR) is known as the important key-player for regulation of thyroid growth and function. As a G-protein coupled receptor (GPCR) TSHR predominantly activates the Gs/adenylyl cyclase and the Gq/11 phospholipase C signaling pathways, that finally regulate thyroid hormone production. Aberrant thyroid hormone production can be caused by activating TSHR mutations in case of toxic thyroid nodules or non-autoimmune hyperthyroidism or via inactivating mutatio...

ea0029n4 | (1) | ICEECE2012

Effect of metformin in teenagers with metabolic syndrome

Rakhimova G N , Azimova Sh Sh , Aliyeva A

Research objective: To estimate efficiency of metformin use in children and teenagers with metabolic syndrome (MetS).Materials and methods: Eighty children and teenagers aged 10–16 with exogenous-constitutional obesity (ECO) were observed. From them in 19 (23.8%) MetS was diagnosed according to diagnostic criteria of IDF (2007); 15 of them (78.9% – seven boys and eight girls) were prescribed metformin (Siofor, Berlin Chemie) in dose from 1000 t...

ea0029p102 | Adrenal cortex | ICEECE2012

Proteomic approach to human adrenocortical cancer biology

Poli G. , Ceni E. , Michelucci E. , Canu L. , Piccini V. , Nesi G. , Cantini G. , Moneti G. , Galli A. , Mannelli M. , Luconi M.

Adrenocortical carcinoma (ACC) is a rare tumor with poor prognosis due to its highly malignant phenotype and lack of effective treatment options.The etiology of ACC is still unknown. To better understand the pathogenesis of this type of tumor and to determine differentially abundant proteins and candidate biomarkers for adrenal cancer diagnosis and prognosis, we used a novel approach based on two-dimensional differential gel electrophoresis (2D-DIGE). Pr...

ea0029p372 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Pituicytoma and meningeoma presenting as suprasellar tumor: case report

Pemovska G. , Krstevska B. , Jovanovska B.

Pituicytoms is a very rare low-grade glioma of the neurohypophysis and can affect both the sellar and suprasellar regions. We describe a case of a suprasellar pituicytoma and mengioma of a patient admitted to our Clinic as a suprasellar tumor patient.Clinical presentation: A 55-years-old man with a history of persistent headache in the right frontal area for a period of 10 years prior to the admission as well as visual disturbances and decreased libido f...

ea0029p451 | Clinical case reports - Thyroid/Others | ICEECE2012

Paraneoplastic severe hyponatremia in a patient with GIST: case report

Bonato V. , Lalle M. , De Mattia G.

Hyponatremia may manifest with nausea, disorientation, seizures, coma, cerebral edema and even death. The etiology of hyponatremia as paraneoplastic syndrome has been attributed most often to high levels of vasopressin. Correction of hyponatremia is usually successful at moderately low sodium levels, although it must be done slowly to prevent osmotic demyelination. Gastrointestinal stromal tumors (GISTs) rarely present paraneoplastic reactions, a few cases have been reported.<...

ea0029p583 | Diabetes | ICEECE2012

Identification of dipeptidyl peptidase-4 inhibitors among boioactive peptides derived from whey proteins

Tulipano G , Faggi L , Caroli A , Cocchi D

Preclinical and clinical studies suggest that whey protein intake can ameliorate postprandial glucose control and potentiate insulin release in both type-2 diabetic patients and healthy subjects.Most likely, the insulinotropic effect of whey occurs by multiple pathways, including the potentiation of incretin activity through inhibition of DPP-4 in the proximal bowel, with the outcome of increasing intact incretin levels.During last...

ea0029p819 | Endocrine tumours and neoplasia | ICEECE2012

Hormone combinations produce unique steroid receptor binding and regulatory profiles in breast cancer cells

Need E. , Swinstead E. , Buchanan G.

Studies into estrogen receptor alpha (ERα), progesterone receptor (PGR) and the androgen receptor (AR) involvement in breast, uterine and prostate cancers has provided considerable insight into the molecular actions these receptors, but have thus far focused on each receptor individually and alone in different cell types. Here, whole genome expression microarray analysis and ChIP-sequencing in ZR-75-1 breast cancer cells, in response to combinations of 17β-estradiol ...

ea0029p897 | Female Reproduction | ICEECE2012

Progesterone levels on the hCG day and outcomes IVF in women with polycystic ovary syndrome

Peng C. , Long X. , Lu G.

Background: The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in IVF in PCOS patients with and without premature luteinization.Methods: Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormon...