Endocrine Abstracts

Issues: This is non-interventional, Demographic, observational study in asian population. Osteoporosis common in Developing-nations. Not-a-single Center exist designated for diagnosis/treatment. No proper epidemiological, mortality/morbidity data available. In asian population Osteoporosis is diagnosed at advanced stage hence poor-prognosis. Worsened by High incidence of malnourished. Increased awareness/improved diagnosis needed to identify cases.Aim: T...

Issues: In developing nations diagnosis of diabetes brings mental-trauma/depression in family. Focused treatment for pediatric age-group is unavailable in developing-countries. 26% of diagnosed diabetics are children’s. Adequately trained physicians/Nurses in issues of pediatric-diabetes provide continuity of care, relief from depression and smooth transition from diagnosis to treatment. Qualitative collaborative relationship between these makes diabetics life bearable. O...

Issues: No specific centre in asia for Osteoporosis patients treatment/rehabilitation. We used locally available Complementary Indian Medicines [CAM] for providing home based care in rural/tribal areas.Aims: To provide CAM to poor patients in collaboration with Traditional-faith-hearers. Evaluated cost-efficacy of CAM & response of pain of fractures to CAM alongside analgesics.Methods: This was a cross sectional, observational ...

Graves’ disease is an autoimmune condition predominantly affecting middle aged women. It can be difficult to manage and consumes a lot of medical time and resources.In Torbay Hospital, we introduced endocrine nurse specialist (ENS) follow up service to reduce medical burden. This has shifted the work-load of patient care but on the other hand, has resulted in identification of great need for support and increased nurse time.We...

The Thyrotropin receptor (TSHR) is known as the important key-player for regulation of thyroid growth and function. As a G-protein coupled receptor (GPCR) TSHR predominantly activates the Gs/adenylyl cyclase and the Gq/11 phospholipase C signaling pathways, that finally regulate thyroid hormone production. Aberrant thyroid hormone production can be caused by activating TSHR mutations in case of toxic thyroid nodules or non-autoimmune hyperthyroidism or via inactivating mutatio...

Research objective: To estimate efficiency of metformin use in children and teenagers with metabolic syndrome (MetS).Materials and methods: Eighty children and teenagers aged 10–16 with exogenous-constitutional obesity (ECO) were observed. From them in 19 (23.8%) MetS was diagnosed according to diagnostic criteria of IDF (2007); 15 of them (78.9% – seven boys and eight girls) were prescribed metformin (Siofor, Berlin Chemie) in dose from 1000 t...

Adrenocortical carcinoma (ACC) is a rare tumor with poor prognosis due to its highly malignant phenotype and lack of effective treatment options.The etiology of ACC is still unknown. To better understand the pathogenesis of this type of tumor and to determine differentially abundant proteins and candidate biomarkers for adrenal cancer diagnosis and prognosis, we used a novel approach based on two-dimensional differential gel electrophoresis (2D-DIGE). Pr...

Pituicytoms is a very rare low-grade glioma of the neurohypophysis and can affect both the sellar and suprasellar regions. We describe a case of a suprasellar pituicytoma and mengioma of a patient admitted to our Clinic as a suprasellar tumor patient.Clinical presentation: A 55-years-old man with a history of persistent headache in the right frontal area for a period of 10 years prior to the admission as well as visual disturbances and decreased libido f...

Hyponatremia may manifest with nausea, disorientation, seizures, coma, cerebral edema and even death. The etiology of hyponatremia as paraneoplastic syndrome has been attributed most often to high levels of vasopressin. Correction of hyponatremia is usually successful at moderately low sodium levels, although it must be done slowly to prevent osmotic demyelination. Gastrointestinal stromal tumors (GISTs) rarely present paraneoplastic reactions, a few cases have been reported.<...

Preclinical and clinical studies suggest that whey protein intake can ameliorate postprandial glucose control and potentiate insulin release in both type-2 diabetic patients and healthy subjects.Most likely, the insulinotropic effect of whey occurs by multiple pathways, including the potentiation of incretin activity through inhibition of DPP-4 in the proximal bowel, with the outcome of increasing intact incretin levels.During last...