Endocrine Abstracts

Sex hormones act both as endocrine signals as well as local paracrine or autocrine factors in the nervous system. In addition to target to classical endocrine and reproductive brain areas, sex hormones and its metabolites affect learning and cognition and regulate the development and plasticity of brain regions that are not directly related to reproduction. Estrogen and progesterone exert neuroprotective effects in the central nervous system and may affect the onset and progre...

Introduction: The prevalence of metabolic syndrome (MetS) is increasing in patients with HIV infection on highly active antiretroviral therapy (HAART). Additionally, HCV coinfection is common among HIV patients in our area. It is widely known MetS impacts on the liver in different ways but relationship between both MetS and liver function is few studied in HIV/HVC co-infected population.Methods/design: Cross-sectional study including 35 HIV/HVC co-infect...

Introduction: The use of glucagon like peptide 1 analogues (GLP1a) for the treatment of type 2 diabetes mellitus (T2DM) is growing. After a decade-long effort to improve the pharmacokinetics of GLP1, a number of GLP1a are currently available on the market. With a view to identifying patient characteristics that could influence physicians’ prescription of different GLP1a we carried out this observational study in routine clinical practice conditions. Outcomes after add-on ...

Introduction: Multiple studies have evaluated the efficacy of SGLT-2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1ra) in patients with type 2 diabetes mellitus (T2DM). However, their efficacy in clinical practice is less known in patients receiving insulin and few are the studies that compare use of SGLT2i vs GLP1ra as add-on therapy to insulin. This study aims to assess clinical efficacy of both treatments in a cohort of patients with T2DM on insulin and poor glycemic...

Introduction: Predictors for therapeutical response of SGLT-2 inhibitors (SGLT2i) is scarcely studied. The aim of the study was to retrospectively analyse the clinical parameters that contribute to the therapeutic outcomes of SGLT2i.Methods/design: We enrolled 75 patients with type 2 diabetes mellitus (T2DM), treated with SGLT2i for longer than three months. The patients were divided into two groups: good responders (if HbA1c-lowering effects were &#8805...

Introduction: Association between liver fibrosis and body mass index (BMI) is well known in HIV/HCV patients, is linked to worse lipid profile and is widely used to predict liver fibrosis in this population. Nevertheless, recent studies show a stronger link between dyslipidemia and liver stiffness with visceral adiposity index (VAI) in general population. The main aim of this study was to investigate the accuracy of VAI and BMI as predictors for liver fibrosis and dyslipidemia...

Introduction: Global mean surface air temperatures have risen by about 1 °C in the past century and are projected to increase by another 1–6 °C by 2100 depending on greenhouse gas emissions. As a result of the increase in mean temperatures, heatwaves have become more severe, frequent, and prevalent. Heat exposure in ambient temperature is associated with all-cause diabetes mortality and all-cause hospitalisation in people with diabetes. However, there is a pauci...

Riedel Thyroiditis is a rare form of infiltrative and fibrotic disease of the thyroid that is characterized by compressive symptoms resulting from a rapidly enlarging goiter. The association with Graves Thyroiditis and autoimmune diseases is very rare. The aim of this presentation is to report a patient with asymptomatic Riedel Thyroiditis associated with Thyroid Storm and Polyglandular Autoimmune Disease. A 54-year-old female patient with recent diagnosis of Grave’s Dise...

Hyponatremia is the electrolyte disorder most commonly encountered in hospitalized patients. The prevalence and characteristics of patients admitted with hyponatremia are analyzed in this study.Description of methods/design: cross sectional study is carried out at the University General Hospital of Valencia, comprising a population of 350,000. 681 of the 30676 patients admitted during the period from January 2014 to December 2015 had hyponatremia include...

Introduction: Our objective is to determine the profile of patients with differentiated thyroid cancer (DTC) attended in our center and the therapeutic approach employed.Methods: Retrospective review of medical records from patients treated for DTC during the years 2013 and 2014.Results: Data from 387 patients, 84% female, 96% Caucasian, mean follow up of 10.82 years. The average age at diagnosis was 44.24 years, 77% had normal thy...