Searchable abstracts of presentations at key conferences in endocrinology

ea0056p248 | Calcium & Vitamin D metabolism | ECE2018

Recurrent hyperparathyroidism: parathyroid carcinoma or parathyromatosis?

Alina Isaic , Flore Varcus , Maria Cornianu , Ioana Golu , Mihaela Vlad

Recurrent hyperparathyroidism (HPT) refers to reappearance of hypercalcemia after a normocalcemic period of at least 6 months post-parathyroidectomy. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism (pHPT), accounting for 0.4–5.2% of cases. Parathyromatosis is defined as small nodules of hyperfunctioning parathyroid tissue scattered in the soft tissues of the neck and/or mediastinum. We describe two cases with recurrent hypercalcemia after surgical int...

ea0081ep823 | Pituitary and Neuroendocrinology | ECE2022

Prevalence of benign and malignant tumors in patients with acromegaly

Plotuna Iulia-Ştefania , Amzar Daniela-Georgiana , Balas Melania , Golu Ioana , Vlad Mihaela

Introduction: Acromegaly is an endocrine disease associated with an abnormal growth-hormone (GH) and insulin-like growth factor 1 (IGF-1) excess. Multiple studies demonstrated an association between these factors and pathways that play a major role in tumor proliferation, survival and resistance to anti-cancer therapies in many human malignancies.Objectives: We wanted to study the incidence and types of tumors which are associated with Acromegaly.<p ...

ea0090p597 | Calcium and Bone | ECE2023

Better late than never - a very rare cause of short stature

Dorogi Carmen , Corlan Ana-Silvia , Golu Ioana , Daniela Toma Andreea , Vlad Mihaela

Introduction: X-linked hypophosphatemic rickets (XLH) is a very rare cause of growth deficiency that can be diagnosed even in adulthood. The mutation of the PHEX gene in these patients causes higher levels of FGF-23 and hypophosphatemia.Case presentation: A 20-year-old male patient was admitted into our clinic due to short stature, walking difficulties, joint and muscle pain, predominantly in the lower limbs. He described the presence of symptoms since c...

ea0063p663 | Interdisciplinary Endocrinology 1 | ECE2019

Diagnotic value of Shear Wave Elastography in differentiating parathyroid adenomas from thyroid nodules

Vlad Mihaela , Golu Ioana , Oprea Maria , Amzar Daniela , Balas Melania , Sporea Ioan

Parathyroid adenomas are situated nearby thyroid gland or even intrathyroidal and could be confounded with thyroid nodules. Ultrasound elastography is a noninvasive technique that explores the elasticity and stiffness of different tissue.Aim: To assess the value of 2D-shear wave elastography (2D-SWE), a new technique of sonoelastography, in the differentiation of parathyroid adenomas from thyroid nodules.Subjects and methods: We st...

ea0049gp53 | Cardiovascular &amp; Lipid Endocrinology | ECE2017

Clinical, laboratory and cardiac parameters in overt primary hypothyroidism versus overt central hypothyroidism

Balas Melania , Parv Florina , Vlad Mihaela , Golu Ioana , Amzar Daniela , Zosin Ioana

Background: Hypothyroidism affects cardiac function, leading to cardiomyopathy, pericarditis, lower left ventricular performance, etc. The present study investigates different parameters (clinical, hormonal, biochemical, echocardiographic) in overt primary hypothyroidism (OPHypo) and overt central hypothyroidism (OCHypo).Material and methods: The study included 33 untreated patients with OCHypo (5 with empty sella, 3 with idiopathic hypopituitarism, 7 wi...

ea0049ep306 | Calcium &amp; Vitamin D metabolism | ECE2017

Hyperparathyroidism and cardiovascular risk

Amzar Daniela , Balas Melania , Golu Ioana , Vlad Mihaela , Sandu Ramona , Cornianu Maria

Background: Primary and secondary hyperparathyroidism (HP) are associated with increased risk for cardiovascular complications and high mortality. Risk factors correlated with hypertension in HP are hyperlipidemia, glucose intolerance, insulin resistance, vitamin D deficiency, etc. The aim of the study was to assess the incidence of cardiovascular complications in HP.Material and methods: The study included 45 patients (15 men, 30 women), with a mean age...

ea0049ep1068 | Pituitary - Clinical | ECE2017

Sheehan’s syndrome in clinical practice

Vlad Mihaela , Golu Ioana , Amzar Daniela , Balas Melania , Butaru Miruna , Milos Ioana , Zosin Ioana

Sheehan’s syndrome represents a rare cause of pituitary insufficiency, produced by an ischemic pituitary necrosis due to a severe haemorrhage at deliverance. Epidemiologic data indicate that, nowadays, this disease is quite rare in developed country.Aim: To determine and evaluate the clinical and hormonal characteristics of cases with Sheehan’s syndrome diagnosed and follow-up in our Clinic, during the last ten years.Subj...

ea0037ep869 | Thyroid cancer | ECE2015

A rare case of an off midline thyroglossal duct cyst papillary thyroid carcinoma

Balas Melania , Golu Ioana , Amzar Daniela , Vlad Mihaela , Ianes Emilia , Dema Alis , Zosin Ioana

Introduction: Papillary thyroid carcinoma can be found very rarely in a thyroglossal duct cyst (TDC) (1%), this cancer variant being the most common type. Although, most of the TDC develop in the midline of the thyroglossal duct (~70%), some cysts occur off midline, within 2 cm of the midline.Case presentation: The female patient of 34-year-old presented at the Maxillofacial Surgery Department in October 2014, with a right submandibular painless neck mas...

ea0037ep1138 | Endocrine tumours | ECE2015

Real-time shear wave elastography in the evaluation of parathyroid adenomas

Vlad Mihaela , Golu Ioana , Amzar Daniela , Balas Melania , Zosin Ioana , Sporea Ioan

Real-time shear wave ultrasound elastography (SWE) is a new technique, which evaluates elasticity and stiffness of the different structure.Aim: To determine the values of the elasticity index (EI) measured by SWE in parathyroid gland adenomas and to compare with those of normal thyroid tissue.Subjects and methods: We studied 50 cases (F/M=42/8), ten with primary or tertiary hyperparathyroidism, diagnosed by specific tests, and 40 h...

ea0035p543 | Endocrine tumours and neoplasia | ECE2014

The prevalence of malignancy in thyroid incidentalomas in an iodine-replete area

Balas Melania , Vlad Mihaela , Golu Ioana , Amzar Daniela , Urian Ananda , Gurban Camelia , Zosin Ioana

Background: Thyroid incidentalomas are reported with increasing incidence in the last decades. The rate of malignancy in these nodules may reach 9% or higher, depending on the patients selection.Material and methods: A retrospective study was done on 429 patients with nodular goiter (issued from an iodine-replete area), admitted in the Clinic of Endocrinology, Timisoara, Romania, from January 2011 to December 2013.Results: The prev...