Endocrine Abstracts

Introduction: Bullous pemphigoid (BP) is an uncommon chronic, autoimmune, and subepidermal disease. It can be associated with drugs, u.v. irradiation, and X-ray therapy. There is a number of reports on bullous pemphigoid (BP) induced by DPP-IV inhibitors (vildagliptin, sitagliptin, saxagliptin). The enzyme DPP-IV degrades glucagon like peptide 1 (GLP-1), which is a potent stimulator of insulin production and secretion. DPP-IV (CD26), present as a cell surface molecule on immun...

Ectopic thyroid is a rare developmental anomaly of the thyroid gland which is defined as the presence of thyroid tissue at a site other than the pretracheal area. Nearly 1–3% of all ectopic thyroids are located in the lateral neck. Simultaneous submandibular ectopic thyroid tissue presenting with a functional orthotopic thyroid gland is extremely rare. A 37-year-old woman was admitted to our outpatient clinic with a cervical mass existing for 3 years. On physical examinat...

NAFLD has become the most common cause of chronic liver disease in obese children.Two years-one month-old boy admitted to clinic for obesity. Parents were first cousin. Weight was 20 kg (>90p), height was 84 cm (50 p), BMI was 28.34 kg/m2 (>97 p). Physical examination was normal except diffuse hypertrichosis and right kriptoorchidism. On the follow-up, he never lost weight. At 4-years-old, FPG was 112 mg/dl, AST was 67 IU, ALT was 72 I...

Obesity is due to the combined effects of genetic, environmental, lifestyle and the interactions of these factors. Leptin (LEP) is an adipocyte-derived hormone that acts to reduce food intake and increase energy expenditure by binding and activating its specific receptor in the hypothalamus. In humans, LEP and LEPR have been mapped to 7q31.3 and lp31, respectively. The LEP and LEPR genes have been investigated in the search for gene variants potentially related to the pathophy...

Background: Diabetes Mellitus (DM) is an endocrine disorder resulting in hyperglycaemia that affects many vital organs of the body like the brain. The molecular mechanisms underlying dementia, memory loss and cognition dysfunction caused by DM are still not very clear. CD47 is a cell surface protein working in the homeostasis of the immune system. The causal relationship of CD47 has been shown in neurodegenerative diseases. CD47 also has a role in pancreatic islet cells and th...

Introduction: In acromegalic patients, the increased mortality and morbidity are generally due to cardiovascular, metabolic, respiratory and cerebrovascular diseases, so early diagnosis and treatment of cardiovascular lesions may save lives. The aim of this study is to find out the any possible difference in terms of carotid intima media thickness (CIMT), indices of arterial stiffness, soluble CD40 ligand (sCD40L) and some echocardiographic parameters between active and inacti...

Primary hyperparathyroidism is a condition related with cardiovascular mortality and morbidity. Aim of this study is to investigate whether there is a difference between healthy controls, hypercalcemic patients with surgical decision and normocalcemic primary hyperparathyroidism patients for parameters like metabolic cardiovascular risk factors, carotis intima media thickness and pulse wave velocity and if there is a difference at patients with surgical decision 6 months after...

Muslims with diabetes are confronted with a dilemma during the annually fasting period: the Ramadan. The Islam foresees a delay of fasting for sick people, but Muslim patients with diabetes do not feel themselves as sick people. How they cope with it?Muslim diabetes patients are contacted in the outpatient department of three hospitals in Antwerp. Well educated students in diet education with a Muslim tradition, question the patients about their food con...

Purpose: Steroid usage may cause hyperglycaemia in non-diabetic patients. We aimed to detect the onset of hyperglycaemia and the best time for glucose measuring over a short time span (1–5 days) in non-diabetic patients who commenced moderate or high dose steroid therapy.Methods: Electronic data of patients, who were commenced moderate or high dose steroid therapy (15–60 mg prednisolone or equivalent dose methyl prednisolone) due to inflammator...

Introduction: Primary hyperparathyrodism is due to benign parathyroid adenomas in more than 90% and parathyroid cancer (PC) in less than 1% of cases. There are no definite clinical criteria differentiating PCs and adenomas. Another subtype, parathyroid neoplasm of uncertain potential is also referred as atypical parathyroid adenoma (APA) and share a few histopathologic features common to cancers.Case: A 47 year old female patient was consulted due to hyp...