Endocrine Abstracts

Objectives: This prospective study aimed at investigating (1) the prevalence of vitamin D deficiency and insufficiency in diabetic adolescents and children in a multi-ethnic cohort, and (2) any association between vitamin D status and ethnic background, glycaemic control (HbA1C), biomarkers of metabolic bone health and lipids.Methodology: Venous blood was drawn from 199 patients with type 1 diabetes (mean age ± SD, 8.2 ± 3.7 years) and 48 patients ...

Introduction: Antiresorptive treatment can preserve bone mineral density (BMD) in patients with primary hyperparathyroidism (PHPT) when surgery is not feasible or desired. We aimed to compare the impact of zoledronate vs denosumab on bone-related biochemical parameters in this population.Methods: We analyzed preliminary data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated either with zoledronate 5 mg...

Objective: Although rapid adrenocorticotrophic hormone (ACTH) stimulation test is a standard test for primary and secondary adrenal insufficiency (AI), it is considered a costly and time-consuming method due to sampling three times in an hour. We aimed to develop a simpler diagnostic model of secondary AI using non-fasting basal cortisol and clinical parameters related to AI such as history of exogenous steroid use or hyponatremia.Methods: Total 430 pati...

Background: Many studies indicated an increased cancer incidence and cancer mortality in subjects with diabetes mellitus. But most of studies have been surveyed in western countries and have problems in applying the results to Korean. We aimed to evaluate the site specific cancer risk of diabetic patients in Korea over 30 years, and investigate causal relationship and temporal relationship by analyzing the organ-specific cancer risk in diabetics according to duration.<p cl...

Acromegaly is associated with a range of comorbidities, including cardiovascular disease, diabetes, hypertension and sleep apnea. Bony overgrowth and soft tissue thickening not only cause typical external features of acromegaly, but also debilitating musculoskeletal aches. Recently, a few papers reported auditory complications of acromegaly, but there has been no report on narrowing of the external auditory canal as a complication of acromegaly. A 58-year-old acromegalic patie...

Objective: In subclinical Cushing’s syndrome (SC), it is assumed that glucocorticoid production is insufficient to cause a clinically recognizable syndrome. Differences in hormonal levels or recovery time of the hypothalamic–pituitary–adrenocortical (HPA) axis after adrenalectomy between patients with overt Cushing’s syndrome (OC) and SC remain unknown.Design and patients: Thirty seven patients (ten were OC and 27 were SC) with adrena...

Introduction: Proinsulin is a propeptide of insulin and C-peptide during physiological insulin production and is increased in patients with type 2 diabetes. Increased proinsulin in peripheral blood indicates impairment of cleavage capacity to process insulin within the beta cell. Recently, chemiluminescence assays have been developed that are able to specifically measure uncleaved intact proinsulin in peripheral blood. In this cross-sectional study, we investigated the relatio...

Background: Fixed-dose radioactive iodine therapy (RAI) is one of the standard therapy for Graves’ disease (GD). However, optimal RAI dose to achieve hypothyroidism in GD has been controversial.Methods: The clinical outcome of 124 patients with GD treated with a RAI between Apr. 2004 and Dec. 2014 was analyzed retrospectively. Responder group was defined as patients who were rendered hypothyroid by the RAI. Thyroid volume (TV) was assessed with sono...

There is limited evidence for the role of screening for Cushing’s syndrome (CS). Patients referred to the specialist medical weight management service at Musgrove Park Hospital have routinely been screened for CS with either an overnight dexamethasone suppression test (ODST) or two 24hour urinary free cortisol (UFC) if evidence of dysglycaemia. We retrospectively analysed the results of all patients referred to the service between 2013–2016. 794 patients were seen as...

Case 1: A 65-year-old man was admitted with symptomatic hypocalcaemia (corrected calcium of 1.65 mmol/l, PTH 46.6 (1.6–6.8) pmol/l, and vitamin D 51.4 (50–150) nmol/l)) 5 days following denosumab initiation. He had a diagnosis of probable urothelial carcinoma with associated osteoblastic metastases, and 10 days prior to this admission had been treated for hypercalcaemia (corrected calcium of 3.04 (2.20–2.60) mmol/l) with i.v. fluids following which denosumab was...