Endocrine Abstracts

Context: Metabolic diseases affect millions of people in both developed and transition countries. In addition to genetic inheritance of risk alleles, emerging evidence has shown that these diseases are also linked to lifestyle and inherited epigenetic pattern interactions. The strong link between epigenetics and metabolism may offer attractive clinical applications to counteract and manage the escalating prevalence of metabolic diseases, such as obesity, type 2 diabetes mellit...

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...

There is a rising use of Aluminium oxide nanoparticles (Al2O3NPs) in many branches of industry and personal care products. Because of these uses, their impact on the environment must be considered and investigated. Almost nothing is known about the effects of Al2O3NPs on semen quality and reproductive hormones. Possible mechanisms for the cytotoxicity of Al2O3NPs are still being discussed, but oxidative stress m...

Introduction: In this report, we describe a rare coexistence of a multifocal papillary thyroid (micro)carcinoma and aldosterone-producing adenoma.Case presentation: A 60-year-old man attended our clinic with a mass in the right adrenal gland was identified during the work-up in 2007. The patient presented complaints on anxiety, tachycardia, and arterial hypertension. He had several episodes of severe hypertension (220/120 mmHg) while sleeping. In 2014, a...

Introduction: Today, thyroid papillary cancer remains to be the most frequent diagnosed malignancy. Despite highly positive outcomes, treatment protocol still requires surgical intervention, which, in turn often affects not only thyroid and regional lymph nodes, but also recurrent nerve and parathyroid glands. The aim of our study was to compare the metabolic compensation of calcium and thyroid metabolism improvement in patients operated on thyroid cancer recently and 20 years...

Introduction: We report a case of a parathyroid carcinoma with very unusual and revealing features.Case report: DAB, male aged 66 was subjected to subtotal gastrectomy because of a localized gastric adenocarcinoma (intestinal type). A mild primary hyperparathyroidism (PTH<200 pg/ml) was simultaneously found. Calcium oxalate nephrolythiasis at 50 years was noted. Sonography revealed a nodular lesion in the right lower thyroid pole, while NMR showed a ...

There is limited evidence on the effect of potassium (K+) supplementation on endothelial function. Three studies suggest a beneficial effect in healthy volunteers and mild hypertensives. However potassium increases aldosterone due to a direct effect on the adrenal gland and there is evidence that aldosterone excess is detrimental to cardiovascular health. We therefore aimed to determine the effect of potassium supplementation on endothelial function in patients with >10% c...

Introduction: Components of metabolic syndrome, particularly overweight, dyslipidemia and diabetes mellitus (DM), are well known cardiovascular risk factors. The objective of this work was to evaluate the metabolic and glycaemic profile in patients (pts) with acute coronary syndrome (ACS), treated in our institution.Methods: A total of 126 pts with ACS (unstable angina, acute myocardial infarction with /STEMI/or without ST-segment elevation/NSTEMI/) were...

Introduction: Perivascular adipose tissue has been implicated in vascular physiology and pathology, including atherosclerosis. Local adipokine production is one of the paracrine mechanisms involved in this adipose tissue fuction. We investigated the expression of adipokines chemerin and adiponectin and their receptors CMKLR1 and T-cadherin, respectively, in human coronary arterial wall and pericoronary fat as well as their correlation with coronary atherosclerosis.<p class...

Introduction: Dyslipidemia is a common finding in patients with primary hyperparathyroidism and together with hypertension and glucose intolerance seems to be responsible by the increased risk of cardiovascular disease in hyperparathyroid patients. In the present work we studied members of a family harboring a MEN1 gene mutation (type 1 multiple endocrine neoplasia syndrome). The penetrance of primary hyperparathyroidism in this condition is close to 100%, starting usually dur...