Endocrine Abstracts

Neuroendocrine tumours, especially pheochromocytomas, paragangliomas and pituitary adenomas, are more common in younger patients in 3rd–5th decade of life. PitNETs are the most common intracranial tumours, while PHEO and PGL are rare. The hormonal activity, signs and symptoms of NET are variable. PGL, PHEO and PitNET in one patient remains an exceptional association. 72 cases of concomitant pituitary adenoma and PGL have been reported to date. The first record of a patien...

Androgen excess in women is most commonly caused by polycystic ovary syndrome (PCOS), but sinister ovarian and adrenal pathology requiring immediate action needs to be excluded. Here we examined whether the severity of androgen excess indicates the likely underlying pathology in women evaluated for androgen excess.We included all women undergoing assessment of serum DHEAS, androstenedione (D4) and testosterone (T) by liquid chromatogra...

Androgen excess in women is most commonly caused by polycystic ovary syndrome (PCOS), but sinister ovarian and adrenal pathology requiring immediate action needs to be excluded. Here we examined whether the severity of androgen excess indicates the likely underlying pathology in women evaluated for androgen excess.We included all women undergoing assessment of serum DHEAS, androstenedione (D4) and testosterone (T) by liquid chromatogra...

Objectives: Polycystic ovary syndrome (PCOS) and thyroid disorders have separately been linked to adverse pregnancy and neonatal outcomes. Even small variations in thyroid function within the normal range may influence fetal growth. Previous data have shown that metformin-treatment of pregnant women with PCOS reduced late miscarriages and preterm births, and resulted in less decrease of fT4 compared to placebo. Moreover, metformin exposure in utero altered the offspring anthro...

Introduction: Low-dose dexamethasone suppression test is used to screen for excess cortisol production (Cushing’s syndrome). It is recommended to use cut-off for suppression of serum cortisol (SC) < 50 nmol/l after 1 mg dexamehason suppression test (DST). Plasma dexamethasone levels are affected by many factors resulting in lower test specificity. Simultaneous analysis of dexamethasone and cortisol levels can improve diagnostic accuracy of DST. We used cut-off level o...

Introduction: Hyponatremia is one of the possible complications of pituitary surgery. Mild, asymptomatic hyponatremia can be managed with fluid restriction and oral supplementation, however more profound hyponatremia, especially when symptomatic, can be a reason for hospital readmission and often needs to be treated with saline infusion in ICU.Aims: To estimate prevalence of hyponatremia and provide clinical characteristics in the cohort of patients who ...

Endocrine-Related Cancer, 2018, 25(2): 131–144 (DOI: https://doi.org/10.1530/ERC-17-0415)...

Objective: The association between thyroid function and mood disorders has long been recognized but little is known about the mechanisms underlying this relationship. Thyroid dysfunction often leads to the development of mental diseases and in patients with affective disorders, 1–4% suffers from hypothyroidism and 4–40% show signs of subclinical hypothyroidism. The aim of the present study was to assess the effects of hypothyroidism on metabolic processes in the brai...

The key metabolic hormone, leptin, acts in part through the liver to regulate glucose homeostasis, as well as the maturation of both adipocytes and osteoblasts. These actions have been demonstrated to be mediated by insulin-like growth factor binding protein 2 (IGFBP-2), independent of its ability to bind IGF1. The effects of IGFBP-2 on adipocyte and osteoblast maturation can be localized to a short peptide sequence within the unique heparin binding domain (HBD-1) of IGFBP-2. ...

Background: Impaired insulin and glucose levels are implicated in the etiology of cardiovascular disease, however, their influence on the formation and composition of atherosclerotic plaque remains unclear.Purpose: To investigate the association between fasting serum insulin and glucose levels with atherosclerotic plaque composition in the carotid artery.Methods: In 1740 participants (mean age 72.9 years, 46% women, 14.4% diabetes ...