Endocrine Abstracts

Objectives: The prevalence of thyreoid diseases eg hyperthyreosis and hypothyreosis in Slovak Republic is about 240 000 patients. The objective of this study was to find out the level of quality of life (QoL) in patients and other relevant characteristics of diseaseas.Methods: The primary method used for the analysis of QoL was the own orginal combined questionnaire. Statistical methods from Excel 2010 were used in results evaluation.<p class="abstex...

Introduction: Agranulocytosis represents a serious complication of thyreostatic (ATD) treatment. The aim of our work was to determine how often did agranulocytosis occur in Graves’ disease patients admitted to the thyroid treatment department of our clinic for RAI treatment between the years 1999 and 2014.Patients and methods: We have retrospectively analysed 699 patients (572 women and 127 men at the average age of 51.5±12.9 years). 327 (47%) ...

Introduction: Lymphomas account for <5% of thyroid malignancies. The vast majority of them are non-Hodgkin’s lymphomas (NHL), especially mucosa-associated lymphoid tissue lymphomas (MALT) and diffuse large B-cell lymphomas (DLBCL). However, Hodgkin’s lymphoma affecting thyroid gland is very rare. Worldwide has been reported <50 cases so far and we describe another one.Case report: A 22-year-old woman was referred to our department of en...

Prolactinomas are the most common hormonally active tumours of the pituitary. The treatment of choice is pharmacological. They are treated with cabergolin, which decreases the level of prolactin as well as the size of the tumour. Rarely, dangerous complications can arise after a quick reduction of the tumour’s size.Case presentation: Two men with macroprolactinomas were initially treated with cabergoline (Dostinex®) in a dose of 1 mg per week w...

Objective: Thyroid hormones are required not only for central nervous system development in the early stages of life but also play a key role in the maintenance of adult brain function. It is known that in adults, thyroid diseases can lead to various clinical manifestations i.e affective disorders, depression, memory impairment. The effects of hypothyroidism on brain functions seem particularly pronounced in depression, but until now, the mechanism underlying this relationship...

Objectives: Between 2010 to 2018, the number of patients with thyroid disease in the Slovak Republic grew by 43.4%. We investigated the development of physical, laboratory, USG thyroid examinations and economic costs over the period 2010–2017.Methods: The study was conducted using data from patient records of the General Health Insurance Company, which registered approximately 3,497,265 policyholders (66.13%) in 2010 and 3,238,500 policyholders (62...

Introduction: Generously supported by IPSEN)-->Acromegaly is associated with increased morbidity and mortality, mainly due to cardiovascular and metabolic complications and higher risk of malignancy. The treatment of choice is selective transsphenoidal surgery (TSS). Successful removal of somatotroph adenoma normalizes GH and IGF1 levels, which improves the patients prognosis. The efficacy of TSS depends on the tumor volume, parasell...

G-protein coupled receptors (GPCRs) represent the largest family of signaling receptors in nature. Their diversity means they play key physiological roles and their dysfunction underlies many pathological conditions, thus they are the focus of many drug design programs due to their primary biological and clinical importance. Our objective is to understand the fundamental mechanisms regulating hormone signaling via GPCRs. Disruption of GPCRs regulation in humans underlies many ...

Lymphocytic hypophysitis is a rare endocrine autoimmune disorder. Principal laboratory markers for diagnosis are antipituitary antibodies (APA). So far there are no standardized methods for the detection of APA and it is not completely clear which antigens are they targeted to as well. At present the indirect immunofluorescence technique is commonly used for their detection. For this purpose cryostat sections of pituitary gland are used. Commercially accessible sections are ac...

We present a family with Von Hippel - Lindau disease (VHL). First two brothers were diagnosed with pheochromocytoma, one of them consecutively in both adrenals in a 16-years’ interval. Then the daughter of one of these two men was diagnosed with pheochromocytoma in both adrenals and one extraadrenal tumour. Later the daughter of the second man was successfully operated for unilateral pheochromocytoma. No neurological signs were present, no other tumours found, and the ocu...