Endocrine Abstracts

Introduction: Dilated cardiomyopathy is the third most common reason for heart failure and transplantation worldwide. The etiology of dilated cardiomyopathy often remains unclear, but in certain cases we can discover the cause, which can then contribute to better and more causal treatment.Observation: We present a case of a 47-year-old man without any significant comorbidities in his medical history. In 2015 he underwent two hemithyroidectomies with a ne...

We present a case report of a 56-year-old woman with MEN1 syndrome diagnosed at the age of 28 years. It was completely expressed by the set – insulinoma, prolactinoma and primary hyperparathyroidism. She underwent resection of 2/3 of the pancreas for symptomatic hypoglycaemia in the age of 28 years (1991). After two resections of parathyroid glands hypocalcaemia replacement was necessary. Prolactinoma was transiently treated with dopamine agonists. In the age of 45 years ...

Paraneoplastic manifestations of well-differentiated thyroid carcinoma are not so common but they can be the first signal of cancer. We present a case of a man with Raynaud’s phenomenon in the area of the lower limb fingers. Clinical signs of Raynaud’s phenomenon with ulceration and gangrene of fingers of both lower limbs appeared several months before the diagnosis of papillary microcarcinoma of the thyroid was made. The diagnosis of carcinoma of the thyroid was det...

Introduction: Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the evaluation and the treatment of LCH.Case: 39 years old woman has had amenorrhea for 2 years and higher intake of fluids (5–7 l/day) for 6 years. Non-functioning pitu...

Introduction: Coexistence of autoimmune thyroiditis (AIT) and papillary thyroid cancer (PTC) has been well documented, but causality is still a matter of debate. Pathogenetic links between PTC and AIT try to explain two theories: 1) PTC is induced or facilitated by AIT, 2) AIT is a response to PTC. It is believed that PTC associated to AIT has a better prognosis.Aims: To find out: 1) the incidence of AIT in PTC patients, 2) the course of PTC associated t...

Objective: Growth hormone (GH) has long been known to have neuroprotective properties. Hypophysectomy (Hx) completely abolishes circulating endocrine GH. Also neuronal (non-erythrocyte) haemoglobin beta chain (Hbb) in the hippocampus decreases following Hx while GH infusions and injections robustly increase the levels approximately 2-4-fold in male rat hippocampus. Recently it has been revealed that Hbb protein is present in mitochondria in the mammalian brain. Current investi...

A 39 year-old man was referred with weight loss and lethargy in 2011. On examination tremor, goitre and mild orbital oedema were present. His past medical history consisted of hypertension (ongoing treatment). Investigations: fT4: 37 pmol/l (9–21), TSH: 0.00 mU/l (0.20–4.50), Anti Thyroid Peroxidase: 242.6 U/ml (0–50) and TRAbs: 11.2 iu/l (0–1.6). Graves’ thyrotoxicosis with moderately active eye disease was diagnosed and he started on carbimazole and ...

Introduction: Thyroidal status can play important role in progression mammary gland tumour growth. We have already shown that hypothyroidism induced by application of 6-n-propylthiouracil (PTU) – inhibitor of type I iodothyronine 5′-deiodinase (5′-DI) – prolonged tumour latency and reduced number, volume and burden of 1-methyl-1-nitrosourea (MNU) induced rat mammary gland tumours in Sprague–Dawley female rats.1<p class="abstex...

Introduction: A diet plan, meals with suitable glycaemic index and sophisticated insulin delivery are used for balanced sacharides–insulin intake. In specific real day-to-day life situations patients must break their activities. Urgency to east in socially inappropriate time harm their lives, especially in young children with diabetes. Night hypoglycaemia, a parental fear of insufficient snack in nursery, sports with prolonged race periods, etc. are among these situations...

Introduction: A transsphenoidal adenectomy (TSFE) is primary treatment of Cushing’s disease. Pharmacological management when the disease persists after surgery is a challenge.Case report: A 47-year-old man was initially diagnosed with CD (petrosal sinus sampling with CRH testing included) after suffering from multiple organ failure in sepsis. Microadenoma 2×4 mm was suspected on the pituitary MRI. Clinical symptoms were markedly improved after ...