Endocrine Abstracts

Background: Struma ovarii is a rare form of the ovarian germ cell tumors composed predominantly of mature thyroid tissue. It occurs mostly in the fifth decade. About 5–10% of these tumors are malignant. We present the case of a 20-year-old-woman with papillary thyroid carcinoma arising in struma ovarii.Case report: A 20-year-old woman presented to her gynecologist with pelvic pain. A right ovarian tumor was discovered at ultrasound examination. The ...

Aim: The aim of multi-center, observational study was to assess the outcome of the treatment with somatostatin analogue octreotide-LAR (O-LAR) patients with acromegaly.Material: Material consisted of 360 patients (60% women) aged 18–84 years (mean 45.5; S.D.±12.9) with active acromegaly. Prior to the inclusion 172 patients underwent unsuccessful neurosurgery.Methods: Observation was planned for 1 year. O-LA...

Introduction: The patients with ACS and scheduled for an elective coronary angiography have high frequency of both newly and previously diagnosed diabetes. The diabetic patients with acute myocardial infarction have an increased risk of death. Elevated blood HYC is strongly related to an increased risk for atherosclerosis and cardiovascular disease. This association is particularly evident in patients with diabetes.Aim of the study: An attempt to evaluat...

Neuropeptides and adipocytokines influence metabolic homeostasis and food intake. Deregulation in their secretion leads to insulin resistance or metabolic syndrome. Adiponectin possesses anti-diabetic and insulin sensitizing properties. Expression of this gene remains under control of nuclear peroxisome proliferator-activated receptor (PPAR)-gamma. Ghrelin, an endogenous ligand for GH secratagogue receptor (GHSR), modulates metabolic homeostasis. A high amino-acid homology and...

Ghrelin is an endogenous ligand of the GH secretagogue receptor. The influence of ghrelin on different organs has been studied recently e.g. in the regulation of pituitary hormone release, regulation of energy homeostasis, glucose metabolism and insulin secretion, cell proliferation and reproductive function.The etiology of PCOS has not been firmly explained, althought several pathways have been implicated – the regulatory pathways of steroid hormon...

Introduction: The adipose tissue secrets visfatin, that might have metabolic effect. Changes of visfatin serum concentrations have been observed in different thyroid pathologies. Thyroid hormones affect metabolism, thus, both hypo- and hyperthyroidism might significantly alter body composition.Aims of the study: We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in severe thyroid dysfunction, and its associations with ins...

Introduction: The time, degree and mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood.Aim: To investigate the time and mode of pituitary function deterioration in the families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed a retrospective longitudinal (33 years, SD=12) analysis of 22 patients (11M/11W) with PROP1 mutation, including...

Background: Craniopharyngiomas are rare, relatively benign, slowly growing intracranial tumors originating in pituitary gland embryonic tissue. They may present at any age, with two peaks of occurrence in children and in older adults. Clinical symptoms are the result of mass effects. Treatment options include surgery, radio- and chemotherapy and unfortunately are connected with a high ratio of postoperative pituitary insufficiency.Aim: To present the lon...

Background: Cushing’s syndrome (CS) is a chronic disorder characterized by endogenous cortisol excess resulting in long-term metabolic and cardiovascular consequences. The identification of metabolic alterations related to hypercortisolism could be beneficial in tailoring treatments of co-morbidities. Our aim was to characterize the metabolic alterations of patients with hypercortisolism by targeted plasma metabolomic profiling.Methods: Subjects (<e...

Introduction: Sex steroid hormones exert a wide range of effects on metabolism. New techniques such as metabolomic profiling allow for a deeper insight into metabolic regulation. In epidemiological samples it has been demonstrated that most of these metabolites show sex-specific differences. However, if these differences are attributable to the effects of sex hormones or genetics is little understood so far.Methods: We performed targeted metabolomics pro...