Endocrine Abstracts

Object: FSTL1, an extracellular glycoprotein, is a novel myokine that is secreted by skeletal muscle. However, its functions in metabolism remain unclear, Adipose tissue is one of the important organs for maintaining energy homeostasis. FSTL1 is known to induce inflammatory response and inhibit insulin-mediated Akt signaling pathway, we aimed to investigate whether FSTL1 play metabolic roles in human adipose tissue. We hypothesized that FSTL1 increases lipolysis throu...

Objective: Triglyceride glucose (TyG) index is considered a surrogate marker of insulin resistance, and insulin resistance is known risk factor of cardiovascular disease. Until now, few studies have investigated the relationship between TyG index and coronary artery calcification (CAC), thus we investigated the correlation between TyG index and CAC in healthy Korean Adults.Methods: A total of 4,463 participants underwent cardiac computed tomography in he...

Background: Given the possible association between dipeptidyl peptidase-4 (DPP-4) inhibitor and risk of diabetic retinopathy (DR), we examined whether DPP-4 inhibitors are beneficial or harmful for DR compared with other glucose-lowering agents.Methods: From a Korean population-based cohort, we identified 67,743 adults with type 2 diabetes treated with oral glucose-lowering agents between 2008 and 2013. Matching (1:1) was done for comparative groups: eve...

Adiponectin has been thought to exert important influences in energy homeostasis and insulin signalling pathway. Some obese individuals showed paradoxical hyperadiponectine-mia (HA), however, the effect of HA on bone metabolism has not been fully clarified.This study aimed to evaluate bone strength and metabolic parameters according to the presence of HA and obesity in Korean adults. A total of 9,172 adults (59.4% women) aged 40–70 years assessed in...

Background: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy.Methods: This historical cohort study included 357 pat...

Background: Recent studies presented that younger patients with papillary thyroid microcarcinoma (PTMC) had poorer clinical outcomes compared to older PTMC patients. The aim of this study is to investigate the impact of patient’s age on the lymph node metastasis (LNM) status of PTMC, a risk factor for recurrence and poor clinical outcome of PTMC.Methods: The study evaluated 2068 PTMC patients who underwent thyroid operation with lymph node (LN) diss...

Background: The prevalence of thyroid cancer has increased very rapidly in Korea. However, there is no data focusing on thyroid cancer mortality in Korea. In this study, we aimed to evaluate standardized thyroid cancer mortality using national data from Statistics Korea.Methods: Population and mortality data from 1985 to 2015 were obtained from Statistics Korea. Age-standardized mortality rates (ASMR) of thyroid cancer per 100 000 were calculated accordi...

Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer and has no effective therapy. Due to its dismal prognosis, it is vital to understand the genetic alterations of ATC and identify effective molecular targets. We performed targeted next-generation sequencing to investigate the mutational profile of ATC using a massive parallel sequencing approach.Methods: DNA from formalin-fixed, paraffin-embedded archival samples...

Background: We evaluated the impact of several anthropometric parameters on serum peak TSH levels after standard two-dose of recombinant human thyrotropin (rhTSH) injection and assessed the usefulness of repeated measurement of TSH and thyroglobulin (Tg) levels at 24 and 72 h after rhTSH injection (Day 3 and 5) to confirm stimulated Tg level.Methods: We retrospectively reviewed 270 differentiated thyroid carcinoma patients who underwent rhTSH stimulation...

Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency.Methods: One hundred and five patients with type 2 diabetes were divide...