Endocrine Abstracts

Sarcoidosis is a granulomatous multi-systemdisorder of unknown ethology. It has a higher prevalence in Northern Europe and the UK. Neurosarcoidosis is a relatively less common, but serious complication of sarcoidosis. CASE: A 48 year old man presented to the hospital with intermittent fever, and neck pain and stiffness, of six weeksduration. This was associated with excessive tiredness, loss of libido, decreased appetite, and unintentional weight loss of two stone over a perio...

Introduction: Incidental indeterminate adrenal nodules discovered on imaging in patients under the care of University Hospitals of Derby and Burton Foundation Trust are discussed in Urology MDT. MDT cases were reviewed for a 12 month period before an endocrinologist joined the MDT in January 2018 and 12 months afterwards, to review the compliance of local practice with European Society of Endocrinology (ESE) Guidelines for the management of adrenal incidentalomas.<p class=...

Background: Chemerin (CHEM) is a newly-discovered adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS).Objectives: The aim of the study was to assess the effect of age on MS prevalence, androgenic status as well as on selected inflammatory indices and CHEM plasma concentrations. Additionally we investigated correlations between CHEM and ...

Introduction: Graves’ orbitopathy (GO) is a rare autoimmune inflammatory disease occurring in 25–50% cases of Graves’ disease (GD). It is associated with poor clinical outcomes, impaired quality of life and socio-economic status. Genetic, environmental and immunological factors are considered to play a role in the pathogenesis of GO, but the effects of neutrophil, lymphocyte counts as well as neutrophil-to-lymphocyte ratio on the pathophysiology of GO are still ...

Introduction: Published studies suggest links between altered actions of thyroid hormones (TH) and cancer development and progression. It is not clear, however, whether these links are specific to cancer types or whether TH can globally affect cancerogenesis. Here, we performed PanCancer analysis of TH signaling pathway.Material/methods: 79 genes linked with TH signaling pathway, including genes encoding proteins involved in TH synthesis, transport, rece...

Introduction: The diagnosis of thyroid orbitopathy is based on clinical symptoms and typical changes in laboratory tests confirming thyroid disease. In approximately 5% it is Hashimoto’s thyroiditis. Typical treatment is primarily steroids administered intravenously. But one disease does not exempts the other, and the drugs can not read. Therefore, we would like to present the history of our patient.Case report: 55 year-old man was admitted to the E...

Adrenal masses are common incidental radiological findings. It has been estimated that as many as 10–20% of patients with essential hypertension may suffer from undiagnosed primary aldosteronism (PA). In patients who have both adrenal incidentaloma, which the functioning one must be identified. We report a case where an unilateral PA was detected on 18F-fluorodexoyglucose (FDG)-positron emission tomography (PET), and comfirmed by adrenal venous sampling.<p ...

Context: Ezetimibe and simvastatin are often used in combination to lower blood lipid levels. The consequences of this combination at the molecular level are unknown.Objective: To examine their effects on the LDL receptor (LDLR) protein expression and on the LDLR and HMG-CoA reductase gene expression in peripheral blood mononuclear cells (PBMC).Design, setting and participants: Prospective, randomized, parallel 3-group trial. Twent...

Cuscuta japonica chois (CJC) has been used traditionally to treat sexual disorder and skin problem such as pimples, freckles and melasma in Korea. The present study aimed to investigate the alleviating effect of CJC extract on surgical injury-induced ischemia in the hind-limb of mice. In this study, Female C57BL/6 mice were ovariectomized and excised the vessels of hind-limb after ligated by surgical silk (6-0). The mice were administered with CJC (150 or 450 mg/kg per day) fo...

Stress is increasingly pervasive in modern society and an unavoidable stimulus to the human organism. Stressors, whether of social or physical type, activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the upregulation of glucocorticoid levels and, in some cases, its de novo biosynthesis. Aside from HPA axis regulation, corticosteroids also modulate the immune response to inflammation and affect the whole-body metabolism. Accurate quantification of endogenous s...