Searchable abstracts of presentations at key conferences in endocrinology

ea0081p336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is there a relationship between nonalcoholic fatty liver disease (NAFLD) and atheroma disease?

Leon Mengibar Josep , Lopez Carolina , Zorzano Marta , Soler Beunza Ana Gloria , De La Fuente Maricruz , Herrerias Fernando , Vilardell Felip , Santamaria Maite , Lecube Albert

Introduction: Over the last few years, there are some studies that suggests a close connection between Nonalcoholic Liver Disease (NAFLD) and increased cardiovascular (CV) risk in population with obesity. Indeed, these two conditions share common drivers, most notably insulin resistance and other elements of the metabolic syndrome. Notwithstanding the above, this affirmation does not have solid scientific evidence. The proliferation of Vasa Vasorum (VV) in the adventitial laye...

ea0081ep13 | Adrenal and Cardiovascular Endocrinology | ECE2022

A challenging case of hypertension: an ACTH-secreting pheochromocytoma

Lanzo Nicola , Fazzino Gaia Francesca Maria , La Barbera Francesca Manzella , Patera Bohdan , Lepanto Silvia , Bianchi Federica Martina , Clementi Ilaria , Piantanida Eliana , Tanda Maria Laura

Pheochromocytoma is a rare catecholamine-secreting tumour arising from chromaffin cells in the adrenal medulla and one of the main causes of endocrine hypertension. We here report the case of a 48-year old man admitted to the Internal Medicine Department for evaluation of resistant hypertension. The patient presented with headache, sweating, palpitations, pitting edema, hypertension and hypokalemia both resistant to conventional polytherapy. He was therefore investigated for e...

ea0081ep303 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence of sarcopenia with different DXA indices in a population with high-risk obesity

Gonzalez Arnaiz Elena , Gonzalez Roza Lucia , Ramos Bachiller Beatriz , Pintor de la Maza Begona , Barajas-Galindo David , Cano Rodriguez Isidoro , Ballesteros-Pomar Maria

Background: Sarcopenic obesity(SO) is an entity characterized by excess fat mass(FM) and low muscle mass (LMM) and function. Excess FM itself can lead to loss of muscle mass and function at any age. The combination of obesity and sarcopenia is a proven risk factor for frailty, comorbidities and mortality. New diagnostic criteria have been developed for this entity.Aims: To assess the prevalence and severity of SO with different indices by DXA, in a group...

ea0090p364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Metformin Ameliorates Fatty Liver Disease in A High-Fat Diet-Induced Obese FVB/N Mouse Model

Lozano de la Haba Samanta , Herman-Sanchez Natalia , Ojeda Perez Betsaida , Garcia-Estrada Antonio , Sarmento-Cabral Andre , M Luque Raul , Gahete Manuel D.

Objectives: Previous studies have shown that metformin can reduce high-fat diet (HFD)-induced body weight gain and fat accumulation in the liver. However, the results obtained in animal models regarding the implication of metformin in the modulation of other whole-body and tissue-specific parameters, are controversial or need to be further explored. Consequently, we aimed to explore the capacity of metformin in modulating glucose/insulin metabolism, liver function, adiposity, ...

ea0090p603 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Strategic Designs to identify the best housekeeping genes for the characterization of biomarkers in adipose tissue of patients with obesity and cancer

Perez Gomez Jesus , Porcel-Pastrana Francisco , de la Luz Borrero Marina , Gahete Manuel D. , Guzman Rocio , Malagon Maria , Luque Raul M.

Obesity (OB) is caused by an energy imbalance that finally leads to adipose tissue dysfunction, and the appearance of multiple comorbidities, such as certain cancer types, including prostate cancer (PCa), which is one of the leading causes of cancer-related death in men population worldwide. In this context, periprostatic adipose tissue (PPAT) has recently gained increased attention as a key regulator of the pathophysiological relationship between OB and PCa. However, it has b...

ea0063p44 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Comparative study between autoimmune metaplastic atrophic gastritis (AMAG) and type 1 gastric neuroendocrine tumors (G-NETs) in Hospital Clínico San Carlos (HCSC), Madrid

Ramos Elvira , Vargas-Zuniga Ignacio , Barrio Elvira , Suarez Pablo , Pazos Mario , Pallares Raquel , Aldama Paula , De La Torre Nuria Garcia , Sevilla Concepcion , Diaz Jose Angel

Introduction: Type 1 Gastric neuroendocrine tumors account for 70 to 80 percent of all gastric neuroendocrine tumors (G-NETs) and they are found more commonly in older adults, particularly women. They are associated with autoimmune metaplastic atrophic gastritis (AMAG) with or without pernicious anemia. Endoscopically, they are usually smaller than 1 cm and often multiple. These tumors usually present a non-aggressive evolution. Our goal is to approach the presence of risk fac...

ea0063p896 | Diabetes, Obesity and Metabolism 3 | ECE2019

NME7 gene is associated with the shape of glucose curves during oral glucose tolerance test

Bendlova Běla , Vejražkova Daniela , Šedova Lucie , Šeda Ondrej , Včelak Josef , Vaňkova Marketa

Introduction: The shape of the glucose curve during oral glucose tolerance test (OGTT) reflects the dynamic of the glucose stimulus-response, and it can be considered as predictor of the impaired glucose tolerance and Type 2 Diabetes (T2D). Nucleoside diphosphate kinase 7, non-metastatic cells 7 (NME7) is an acknowledged member of ciliome and is involved in the biogenesis or function of cilia. Due to the fact that obesity and T2D are common in several ciliopathies, we enrolled...

ea0049gp198 | Thyroid 1 | ECE2017

Which is the best tool to use when initiating the differential diagnosis of a thyrotoxic patient? A challenge to current guideline recommendations

Perdomo Carolina , Ramos Elisa Gil , Buey Gala Gutierrez , Llavero Maria , Gargallo Javier , Arbizu Javier , de la Higuera Magdalena , Galofre Juan C

Aim: Differential diagnosis (DD) of thyrotoxicosis is critical as the treatment of the three main causes of this condition (GravesÂ’ disease [GD], Toxic Multinodular Goitre [TMG], and Thyroiditis [TS]) differs substantially. Recently published diagnostic algorithms investigating hyperthyroidism embrace the presence of thyrotropin receptor (TSH-R) antibodies (TRab) as the first and most cruicial diagnostic step. Although TRab measurement has important limitations (some can ...

ea0049gp235 | Thyroid Cancer | ECE2017

Clinical Utility of response to therapy in combination with BRAF in risk assessment of thyroid cancer

Fernandez Laura Perez , De la Vieja Escolar Antonio , Zafon Carles , Galofre Juan Carlos , Riesco-Eizaguirre Garcilaso , Spanish Task Force for the study of BRAF SEEN Garcilaso

Response to therapy re-stratification approach has been recently included in the 2015 ATA guidelines as a risk-adapted approach to management of thyroid cancer. Our aim was to investigate the clinical utility of response to therapy variables obtained during early follow-up in combination with BRAF, a prominent oncogene in thyroid cancer with prognostic value. This was a retrospective multicenter study of 871 patients at 11 centers in Spain with papillary thyroid cancer followe...

ea0049ep125 | Clinical case reports - Pituitary/Adrenal | ECE2017

Incidentaloma as a first manifestation of lymphoma

Diaz Pamela R. Chavez , Escola Cristina Alvarez , Larrauri Miriam Zapatero , Gomez Jose Tomas Castell , Bazan Alfredo Aguilera , de la Morena Lucrecia Herranz

Introduction: Incidentally discovered adrenal masses (incidentalomas) are common and in some cases differential diagnosis could be a challenge.Case report: A 55-years old woman presented with an incidental left adrenal mass of 36mm discovered on an abdominal ultrasound. As sole background she underwent resective surgery of an ovarian serous cyst. She denied symptoms like flushing, headache, diaphoresis or palpitations. Physical examination was irrelevant...