Endocrine Abstracts

Hormonal signalling plays a key role in the progression of metabolic (dysfunction)-associated fatty liver disease (MAFLD) to hepatocellular carcinoma (HCC). However, the role of somatostatin (SST), cortistatin (CORT), neuronostatin (NST) and ghrelin systems in MAFLD-HCC progression has not yet been elucidated. We characterized the role of SST/CORT/NST and ghrelin systems in chronic liver disease and evaluated their clinical potential. The expression of the components of the SS...

Introduction: Real-world data on glucose and weight control effectiveness in patients with Type 2 diabetes mellitus (T2DM) on treatment with semaglutide is scarce. We aim to assess it in a cohort of patients from a real-world setting in Spain.Materials and methods: We identified 830 patients with T2DM that were prescribed Semaglutide once-weekly since May 2019 to December 2020, in 4 hospitals in Madrid-Spain. At 6±3 months, 435 GPL1-naïve and 3...

Introduction: Terlipressin is a non-selective vasopressin analogue used in patients with decompensated cirrhosis, gastrointestinal haemorrhage or hepatorenal syndrome. It directly binds to V1 receptors improving circulatory volume by causing splanchnic vasoconstriction and portal hypertension inhibition, and has a full V2 receptor agonism in the collecting duct. In consequence, it increases reabsorption of water and can lead to a decrease in plasma osmolality and hyponatremia....

The lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue with the apparent accumulation of fat in other regions of the body. Their prevalence is low and ranges from 1:200000/500000 and they usually suffer metabolic abnormalities associated with the abnormal distributition of fat such as severe insulin resistance with acantosis and diabetes, progressive liver disease along with ...

Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial and complex chronic disease characterized by insulin resistance and a dysfunctional adipose tissue. T2DM patients usually present a state of low-grade inflammation due to a dysregulation of the cytokine production. Consequently, this seems to contribute to insulin resistance and beta cell failure associated with the progression of this disease.Objective: To examine expression of Interleuki...

Background: Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, the identification of novel molecular targets for treatment is urgently needed to improve patients’ outcomes. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative-splicing processes might be used as potential novel therapeutic tools for PCa. In this context, although RBM22 has been id...

Intracranial tumors (IT) comprise a heterogenous group of neoplasias (e.g., pituitary/brain tumors and craniopharyngiomas), characterized by difficult diagnosis based on MRI, challenging prognostic predictors and lack of effective therapeutic strategies. In addition, these tumors are usually associated with neurological disorders and severe comorbidities (e.g., those associated with Cushing syndrome, Acromegaly, etc.), worsening the quality life of patients. In this context, s...

High-grade astrocytomas (HGAs) remain the most prevalent and malignant brain tumor based on its locally aggressive behavior, being glioblastoma (grade-IV astrocytoma) the most lethal. The current standard treatment for glioblastomas consists of surgery followed by radiotherapy and/or chemotherapy. However, the average period of survival is about 14 months after the first intervention. Therefore, there is a clear clinical need for the identification of novel diagnostic, prognos...

Mechanisms regulating the selection of antral ovarian follicles are poorly understood and supposed to rely on low estrogen levels, decline of follicle-stimulating hormone (FSH) levels and receptor (FSHR) expression on the surface of granulosa cells. These concepts are challenged in-vitro, where apoptosis of human granulosa cells (hGLC) and transfected cell lines is induced by high doses of FSH or FSHR overexpression, while estrogens induce anti-apoptotic signals via n...

Introduction: Hyponatremia (HN) is associated with worse clinical outcomes, and longer hospital lengths-of-stay than seen in eunatremic patients. The Syndrome of Inappropriate Antidiuresis (SIAD) is the most common cause of hyponatremia in hospitalization. We studied the relationship between correction of sustained SIAD-induced hyponatremia and visits to the Emergency Room (ERv) as well as hospital admissions (HA) in a case series.Methods: Retrospective,...