Endocrine Abstracts

Introduction: Ovarian cancer is the most lethal gynecological malignancy. Early diagnosis has a survival rate of 90%. Unfortunately, more than 70% of cases are diagnosed when the cancer has already metastasized, and survival rates do not exceed 30% in these cases. The sodium iodide symporter (NIS) is an integral plasma membrane glycoprotein expressed in the basolateral surface of the thyroid gland, where it mediates active transport of iodide. Radioiodide therapy (RAI) through...

Introduction: Hyponatremia is the most frequent electrolyte alteration in hospitalized patients, and is associated with increased morbimortality. Hyponatremia in patients receiving parenteral nutrition (PN) is generally overlooked. Our objective was to classify the types of hyponatremia observed in patients on PN, and to describe the prescribed treatments and evolution.Material and methods: We undertook a prospective study of all patients on medical ward...

Background: Up to 15% of pheochromocytomas are malignant. The only definite criterion for malignancy is the presence of metastases. The histological differentiation between benign and malignant tumours is difficult, being a challenging problem nowadays.Aim: To asses if postoperative histological evaluation using the previously proposed pheochromocytoma of the adrenal gland scales scored (PASS) can predict malignancy.Methods: Twenty...

Introduction: Successful whole pancreas transplantation is at the present the most effective treatment for type 1 diabetes but allograft dysfunction related with infection, vascular compromise or immunological causes are not uncommon. Usually, graft vascular thrombosis or haemorrhage, as well as infectious complications are responsible for early pancreas graft failure; late cases occur more frequently by immunological causes, either allograft rejection or recurrence of the &#1...

Objective: To study if the use of continuous glucose monitoritation systems in real time (GUARDIAN REAL TIME®) in the diabetic patients could improve the metabolic control.Material and method: 15 type 1diabetic patients studied (age: 33.8±13.40, years of evolution: 17.06±11.32) in intensive treatment (5 multidoses, 10 insulin pump) which were made one first blind 4 days long monitoritation to them, PERIOD 1 (P. BLIND) with senso...

Human breast cancer tissue is able to concentrate estrogens. 17-beta-estradiol (E2) and estrone (E1) are produced locally through several mechanisms, e.g. from conjugated and unconjugated steroid hormones uptaken from the circulation. This study was aimed to investigate the correlation between endogenous serum sex steroid concentrations and tumour receptor status in postmenopausal breast cancer patients undergoing surgical intervention. The study involved 740 postmenopausal pa...

Background: Typing somatostatin receptor (SSTR) expression in neuroendocrine tumors (NETs) is of relevance to target an octreotide-based diagnostic approach and treatment. The expanding use of immunohistochemistry to detect SSTR is to date not paralleled by an accurate methodological setting and standardized interpretation of the results.Objective: A multicentric study was designed to compare SSTR immunohistochemical expression with in vivo scinti...

The present study was undertaken to evaluate the diagnostic performance of a high-sensitive thyroglobulin (Tg) immunoradiometric assay (BRAHMS Tg-S) in the follow-up of papillary and follicular thyroid cancer patients treated with total/nearly total thyreoidectomy and radioiodine ablation therapy. During TSH suppression serum Tg concentration was measured 6 weeks prior to the radioiodine ablation (onT4-Tg before ablation) as well as 3 months following treatment (onT4–Tg a...

Background: Acromegaly is usually caused by a benign pituitary tumour, with increased production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Treatment options include surgery, followed by pharmacological treatment with dopamine agonists, somatostatin analogues, GH receptor antagonists or radiotherapy. Treatment optimization is important to decrease the burden of this often-chronic disease on the patient.Objectives: To evaluate the ef...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico and it could become in a public health problem, this one understands a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indexes have been proposed, such as non-invasive techniques, however there are very few studies in our population. This study aims to compare...