Endocrine Abstracts

Materials and methods: The aims were to evaluate the frequency of nodular thyroid disease (NTD) in acromegalic patients and to correlate clinical and metabolic features with disease activity and other. We conducted a cross-sectional study including retrospectively 69 acromegalic patients attending to an University Hospital in Madrid, Spain between 1980 and 2016. Mean age was 63 (32–92) years, 63.8% of patients were female. Mean age at diagnosis of acromegaly was 48 (11&#1...

Background: Traumatic brain injury (TBI) is a major cause of disability and death, and a cause of neuroendocrine dysfunction. Partial or complete pituitary dysfunction is a frequent event occurring in 25–50% of subjects after a TBI as result from damage to either the pituitary or the hypothalamus. This large variability depends on the screening methods and on the difficulty to predict the effects of the trauma on pituitary. Growth hormone deficiency and gonadotropin defic...

Objectives: DOTAMZOL is a DOTA-conjugated bisphosphonate which can be used for diagnostic (44Sc, 68Ga) or therapeutic (177Lu) applications. The aim of this study was to evaluate the adaption of the radiolabelling process on an automated module utilizing NaCl-post processing, with regard to clinical application and additional radiation protection point of view.Methods: 68Ga was obtained from a 1.5 yea...

Disorders of sex development (DSD) are a collection of rare congenital conditions with diverse features and pathophysiology. Patients usually present at birth with atypical genitalia or with delayed puberty in adolescence. Biochemical and cytogenetic investigations may provide guidance on the underlying cause, however molecular genetic analysis is usually required to provide a definitive diagnosis and allows for personalised management of the patient. The current diagnostic se...

Introduction: Diabetes Mellitus (DM) is 2–4 times more common in Turner Syndrome (TS) than karyotype normal females. Diagnosis of DM in TS is usually based on age of presentation and insulin dependency without regard for DM- autoimmunity. Previous research has identified DM associations with the isochromosome and ring chromosome. However, only small numbers of diabetics have been included in reports so far. Here we present preliminary data on DM characterisation in TS.</p...

Background: Shift workers and rodents with clock gene mutations show increased risk of metabolic syndrome and type 2 diabetes (T2DM). Conversely, obesity and T2DM are related to circadian disturbances in humans and rodents. The circadian release of adipokines from white adipose tissue (WAT) plays a pivotal role in energy metabolism. Its regulatory mechanism is unclear at present.Aim: To determine the daily expression patterns of genes involved in circadi...

A 78-year-old female presented with acute onset of severe headache and vomiting. Sub arachnoid haemorrhage was suspected but a CT brain scan was ‘normal’ and CSF bilirubin absent.Three months later she complained of lethargy and a thyroid function test suggested secondary hypothyroidism. Further investigations confirmed partial hypopituitarism (growth hormone preserved) and review of the previous CT scan suggested the presence of a pituitary ma...

A Multicystic dysplastic kidney (MCDK) is a congenital, renal, cystic transformation usually diagnosed perinatally with 1:1000-4,000 incidence1. The natural history of MCDK is disputed with involution1, enlargement and development of hypertension2, infection and malignant transformation reported in the literature. We describe the incidental detection of An occult MCDK was detected in a 25-year-old chef who presented with a 4 month history of di...

We examined the functional significance of the glutamatergic innervation of the dorsal raphe nucleus (DR) in the mediation of the suckling stimulus inducing prolactin release. A non-NMDA (6-cyano-7-nitroquinoxaline-2,3-dione disodium, CNQX) or an NMDA glutamate receptor antagonist (dizocilpine hydrogen malate, MK-801) was injected into the DR of freely moving lactating rats at the end of 4 h separation. The litters were then returned and blood samples for prolactin were taken ...

A Multicystic Dysplastic Kidney (MCDK) is a congenital, renal, cystic transformation usually diagnosed perinatally with 1:1000 to 4,000 incidence1. The natural history of MCDK is disputed with involution1, enlargement and development of hypertension2, infection and malignant transformation reported in the literature. We describe the case of a 25-year-old chef in whom an occult MCDK was incidentally detected. He presented with a four month histo...