Endocrine Abstracts

Metastases in the thyroid gland are very rare and their true incidence has not been clearly established. There are few reports of metastases to this gland and most of them are not detected in clinical practice.Although detection of metastases to the thyroid gland usually indicates poor prognosis aggressive surgical and medical treatment in isolated thyroid metastases may be effective as described for renal carcinoma.Malignant melan...

Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease resulting from adrenal unresponsiveness to ACTH. Patients present in early childhood with hyperpigmentation, hypoglycaemic episodes and seizures secondary to glucocorticoid deficiency. If left untreated this condition is fatal. Mineralocorticoid production is normal. Mutations in the ACTH receptor have been well described and account for approximately 25% of cases. We describe 3 additional novel mut...

Introduction: Turner syndrome (TS), defined by the loss of X chromosome material, affecting 1/2500 females born. Associated with TS are a variety of comorbidities such as obesity and fatty liver disease, many of which increase in prevalence with age. The Turner Syndrome Life Course Project at UCLH has collected data on over 800 women over the last 20 years. Annual health surveillance in our adult TS clinic allows for screening for liver enzymes, such as Alanine Transaminase (A...

A 69-year-old patient with a history of hysterectomy 18 years ago due to apparent uterine myomatosis, who presents with a clinical picture of 6 months of evolution of a solid suprapubic mass without any other associated symptomatology. Normal vaginal cytology 3 years ago; Menarche at 16 years of age and obstetric history: G1P2V2(Twin).Physical examination: Indurated mass in the suprapubic region, mobile, not painful External atrophic genitalia; Vaginal e...

IntroductionThe association between parathyroid and thyroid diseases is not uncommon; however concurrent presence of parathyroid adenoma and thyroid cancer is rare (1). As a natural consequence, preoperative imaging studies for diagnosis and localization of parathyroid adenomas may result with the detection of thyroid incidentalomas and most of these thyroid nodules should be evaluated by fine-needle aspiration biopsy before parathyroid surgery (1). We h...

Objectives: The development of drugs to aid weight loss as an adjunct to dietary and lifestyle recommendations prior to surgical treatment of obesity may help in the management of these patients. To compare the percentage of weight loss among patients who received dietary recommendations (Group 1) and lifestyle recommendations vs those who added arGLP1 semaglutide 1 mg sc (Group 2) or liraglutide 3 mg sc (Group 3) to these recommendations, analysing other variables such as the...

Introduction and Objectives: Despite the many known advantages of Flash Glucose Monitoring (FGM), very few studies have shown a real improvement in the patient’s overall quality of life. Therefore, our aim is to assess, using the validated Diabetes Mellitus Specific Quality of Life Questionnaire: Spanish version (EsDQOL), whether these differences really exist in our population.Methods: An observational, prospective study was conducted comparing qua...

Prostate cancer (PCa) represents the most diagnosed tumour pathology in developed countries among men population. The main pharmacological approach to treat this pathology is based on the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this therapy, therefore developing castration-resistant prostate cancer (CRPC), the most aggressive phenotype of this pathology, which ...

Introduction: Diabetes mellitus secondary to exocrine pancreas diseases (pancreatogenic DM) has an unknown incidence and is considered underdiagnosed. Our objective was to evaluate the glycemic control parameters in patients with pancreatogenic DM who started Flash glucose monitoring (FGM).Methods: Prospective, observational study in a Spanish hospital. Patients with pancreatogenic DM who started FGM from January 2021 to August 2022 were recruited. Patie...

Background: Prostate cancer (PCa) diagnosis is based on the serum levels of prostatic specific antigen (PSA), which might be influenced by many clinical conditions, including obesity. In addition, the diagnostic capability of PSA test dramatically drops when considering patients with PSA levels lower than 10ng/mL (i.e. “grey-zone”). Therefore, the identification of more reliable non-invasive diagnostic biomarkers for PCa is a critical unmet clinical need. In this sce...