Endocrine Abstracts

Introduction: Although underlying mechanisms are largely unknown, bone metabolism is regulated by specific microRNAs and changes in their expression are associated with metabolic bone disorders. Exercise is a determinant of bone metabolism; however, different training protocols differently affect bone. Little is known about the effects of exercise on bone-specific miRNA expression.We studied the effect of a 8-week high-intensity training protocol on circ...

Background: Luteinizing hormone (LH) and choriogonadotropin (hCG) are glycoprotein hormones regulating ovarian function and pregnancy. They were routinely used in assisted reproduction techniques (ART) assuming they are equivalent, due to their binding to a common receptor (LHCGR). However, differences between LH and hCG were demonstrated at molecular and physiological level.Aim: The aim of this study is to evaluate how follicle-stimulating hormone (FSH)...

Introduction: It is known that about 75% of cases of endogenous Cushing síndorme to a pituitary adenoma (HA) ACTH-producing, 15% to ectopic ACTH and 10% is due to adrenal adenoma.Case: The patient was 64 years old, derived from Diabetes Mellitus type 2 of about 16 years of history with an unwieldy+hypertension diagnosed in 2007 with no physical signs compatible with hypercortisolism and incidentally detected a left adrenal adenoma 2 cm. Hormonal blo...

Background: The prolactin/vasoinhibin axis constitutes a novel endocrine axis in which the generation, secretion, and actions of the pituitary hormones prolactin and vasoinhibins are under control of the hypothalamus, the pituitary gland, and of regulators in the target tissue microenvironment. Vasoinhibins are generated in the pituitary gland and in multiple target tissues through proteolytic cleavage of prolactin; it is not known wether they are also produced in the circulat...

Women with Turners Syndrome (TS) have been shown to have reduced bone mineral density (BMD) but there is uncertainty about how this relates to fracture risk. The little data that does exist is conflicting, with one case series finding no difference compared to controls and one survey suggesting an increased risk of fracture particularly of the forearm. Proposed mechanisms for reduced BMD include short stature, oestrogen deficiency and bone dysplasia. In addition, fracture risk...

Introduction: Alterations in foetal growth lead to neonatal health risks and favour metabolic diseases during adult life. Therefore, the study of birth weight determination and its modifications is crucial for metabolic diseases prevention. Placental growth is a key factor in foetal growth. It has been suggested that insulin and the IGF system play an important role in foetal growth and placental development and function. Although, insulin and IGFs in the umbilical cord blood ...

Anti-Mullerian hormone (AMH), a member of transforming growth factor β (TGF-β), shows different sex-related functions. In male, from the fetal development till the puberty, the expression of AMH by Sertoli cells causes regression of Mullerian ducts with subsequent testicular differentiation. Mainly studied in female, AMH produced by ovarian granulosa cells inhibits both initiation of primordial follicle growth and the FSH-stimulated follicle growth. Moreover, recent ...

MIH for Molar Incisor Hypomineralization is a recently described pathology affecting around 18% of six year old children. Although a number of putative factors have been hypothesized, etiology of MIH remains unknown. The parallel increase of exposure to endocrine disruptors (EDs) and the prevalence of MIH led us to investigate a possible relationship between both events.Rats were orally exposed daily to low dose of bisphenol A (BPA), genistein, vinclozol...

Objective: To develop a specific questionnaire to evaluate the satisfaction of diabetic patients with the use of glucometers and evaluate their psychometric properties (feasibility, reliability, and validity).Material and methods: Two stages: i) questionnaire development: a set of 53 items was constructed after a bibliographic review. A panel of six experts and 50 patients concluded a 25-item version of the questionnaire (dimensions: satisfaction, inconv...

Introduction: LH and hCG act on the same receptor (LHCGR), but it is not known whether they elicit the same cellular and molecular response. This study aims at comparing the activation of cell-signalling pathways and gene expression in response to LH and hCG.Design: We evaluated the activation of cAMP, ERK and AKT-pathways and progesterone production by ELISA and Western blotting in human primary granulosa cells (hGLC) stimulated for up to 36 hours with ...