Endocrine Abstracts

The aims of this study were to determine the prevalence of pituitary dysfunction in patients keeping neuropsychological disabilities long after TBI (at least 1 year), to research predictive factors and to evaluate consequences of endocrine abnormalities on metabolism and quality of life in these patients.We studied 50 patients (42 men, mean age 36, range 20–59 years, mean BMI 25, range 17–42 kg/m2) who had survived severe (n=3...

Background: Women with a history of gestational diabetes mellitus (GDM) are at increased risk for diabetes and lipid alterations.Objective: In a cohort of women with previous GDM, we aimed to ascertain whether women with abnormal glucose tolerance one year post-delivery had a more atherogenic lipid profile after pregnancy than those with normal glucose tolerance.Design and patients: A descriptive study of GDM women who underwent pr...

IntroductionThe incidence of primary hyperparathyroidism (PHPT) increases with age; however, the clinical presentation might change with aging. We aimed to compare the clinical presentation of older and younger patients with PHPT.MethodsWe retrospectively analyzed the biochemical status, renal involvement, and bone mineral density (BMD) of patients who were diagnosed with PHPT at our endocrine clinic from 200...

IntroductionThe use of iSGLT2 remains controversial in diabetic patients with peripheral arterial disease.ObjectivesAssess metabolic effect and risk of amputations of iSGLT2 in diabetic patients treated in the Multidisciplinary Unit of Diabetic Foot (MUDF) comparatively with a control group.Design and methodsRetrospective observational study in which the patients ...

Introduction and objectivesThyroid cancer treatment tends to be individualized based on risk stratification and increasingly less aggressive for low-risk tumors, as recent studies have shown that low doses of I-131 are just as effective than higher doses with excellent remission rates. The objective of our study was to evaluate the response after 1 year of treatment with 30 mCi of I-131 in patients with differentiated thyroid cancer.<p class="abstext...

Objective: This study aims to compare 1-month’s efficacy and safety of single-session ethanol ablation and radiofrequency ablation for treating both purely cystic nodules and predominantly cystic thyroid nodulesMaterials and Methods: This short-term retrospective study was approved by the Ethics Committee of the Institutional Review Board of Danang Family hospital, and written informed consent for procedures was obtained for all patients. 39 patient...

Background: Tyrosine kinase inhibitors (TKIs) are modern antineoplastic molecules widely used in the medical treatment of many cancers including iodine refractory differentiated thyroid carcer (DTC) and advanced medullary thyroid cancer (MTC). In patients with thyroid gland, TKIs frequently cause a destructive and/or autoimmune thyroiditis with consequent hypothyroidism. However, authors have reported unexpected TSH increase or hypothyroidism even in patients with total thyroi...

Background: G3NETs demonstrate variable clinical behavior (Ki-67>20-100%). Treatment extrapolated from grade 1/2 (G1/2) NETs and neuroendocrine carcinomas depending on clinicopathologic features. Therapy for treatment-emergent G3NETs remains especially ill-defined.Methods: Retrospective chart review of patients with de novo G3NETs or progressing from low-to-high grade (L-H) (G1/2 at diagnosis and G3 >=3 months later). Treatment patterns compared ...

Background: The role of surgical cytoreduction for metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is considered an area of debate due to lack of prospective data. While retrospective and single institution analyses demonstrated higher survival rates associated with surgical cytoreduction, there was no comparison with systemic therapies alone in these studies. The aim of this analysis of the National Cancer Database (NCDB) was to evaluate the survival benefi...

Introduction: Potent 11β-hydroxylase inhibitor osilodrostat provides cortisol level control in patients with Cushing’s syndrome (CS), as demonstrated by the LINC clinical development programme in Cushing’s disease (CD) patients.1 We report data from year 1 of the prospective observational LINC6 study (NCT05382156), evaluating long-term safety and efficacy of osilodrostat in CS patients during 3 years of routine clinical practice.<p class="abstext"...