Endocrine Abstracts

Introduction: Proton pump inhibitors (PPIs) are commonly prescribed drugs. We report a case of severe hypocalcaemia secondary to omeprazole-induced hypomagnesaemia.Case report: A 85-year-old Chinese man with stage 4 chronic kidney disease was admitted to our hospital in Jun 2014 with vomiting and weakness. On admission, he was severely hypocalcaemic (adjusted calcium 1.37 mmol/l (RI: 2.15–2.58)) and hypomagnesaemic (Mg 0.1 mmol/l (RI: 0.7–1.0))...

Mutations in CYP11A1, like those in STAR cause lipoid congenital adrenal hyperplasia manifesting with adrenal and gonadal insufficiencies along with derangements of the renin/angiotensin system. Increased adrenal size is usually a feature of STAR but not of CYP11A1 mutation. Milder forms presenting without all of these features have also been described. We present six patients from four families with CYP11A1 mutations discovered by ...

Objective: To investigate the effects of C1q/TNF related protein 3 CTRP3 on the insulin sensitivity of adipocyte and its possible mechanisms.Methods: The insulin resistance model of 3T3-L1 adipocyte was induced by palmic acid (PA) cultivation. Such adipocytes were treated with different concentration of recombinant CTRP3 (0,10,50,250,1250 ng/ml) for 12 h, and for different time (2, 6, 12, 24 h) at the concentration of 250 ng/ml. The glucose consumption w...

Introduction: We have previously demonstrated that APPL1 maintains glucose homeostasis by promoting both actions and secretion of insulin. Although APPL2 is a close homolog of APPL1, the physiological function of APPL2 is vaguely characterized. Thus, we generated a knockout (KO) mouse model in which APPL2 is deleted in pancreatic β-cells and hypothalamus (which is called APPL2 KO mice) to investigate its role in glucose and energy metabolism.Methods...

Objective: To investigate the impact of the serum testosterone on the metabolic syndrome (MS) in young and middle-aged men with type 2 diabetes mellitus (T2DM).Methods: A total of 220 young-and middle-aged (18–50) men with T2DM were recruited in this study and were divided into four groups based on serum testosterone quartile. General information, smoking history and anthropometry data were collected. Fasting glucose, fasting insulin, blood fat and ...

Objective: To examine the relationship between C-peptide levels and endogenous insulin secretion and to understand the effects of elevated C-peptide after dosing on evaluating study insulin and its analogs’ PK/PD values in euglycemic clamps.Method: The study included 33 healthy male volunteers who underwent an 8-h euglycemic clamp with a subcutaneous injection of insulin aspart (0.2 U/kg). Blood glucose (BG), C-peptide, human insulin, and insu...

Tobacco smoke (TS) is the major cause of lung cancer, including pulmonary neuroendocrine tumors such as small cell lung cancer and large cell neuroendocrine carcinoma. Unlike squamous cell carcinomas and adenocarcinomas, the precursor lesions for subtypes of pulmonary neuroendocrine tumors have not been historically defined, and theexpression of neuroendocrine markers has been served as critical indices for the identification of these tumors. Mitogen-activated protein kinases ...

Objectives: This study aims to determine which metabolic tissue is involved in the process of kisspeptin neurons regulate energy metabolism so that it may provide a novel therapy for metabolic related diseases such as obesity.Methods: Kiss1-CreGFP mice were used in this study. And we selectively activated kisspeptin neurons by using Designer-receptors-exclusively-activated-by-designer-drugs (DREADDs) technology. Mice were bilaterally injected with the Cr...

Aims: Maternal dyslipidemia during pregnancy is more serve in GDM women compared with non–GDM women. The occurrence of postpartum hyperglycemia is associated with increased lipid profiles. The purpose of this study was to evaluate the relationship between lipid changes and early postpartum abnormal glucose metabolism (AGM) of women with prior GDM history.Methods: 395 patients with a history of GDM who had a postpartum OGTT were included in this ret...

Introduction: In recent years a growing number of gene mutations have been identified which cause a myriad of syndromes having adrenal insufficiency as a core characteristic. The evolution of each syndrome is dependent on the variant and the particular gene affected. Common practice is for candidate genes to be sequenced individually, which can be time consuming and is complicated by overlapping clinical phenotypes. The increasing availability and cost effectiveness of whole e...