Endocrine Abstracts

Background: Patients with neuroendocrine neoplasms (NENs) have a high burden of chronic symptoms. We assessed symptom burden and overall quality of life (QOL) for eNET study participants and analyzed differences by age, sex, and NEN primary site.Methods: eNET is a prospective, cohort study on the Eureka digital health platform enrolling individuals with advanced NENs. Participants completed validated surveys on an internet-supported device at baseline an...

Objective: To summarise and analyze the pathogenesis, clinical risk assessment, and treatment of venous thromboembolic events (VTE) associated with Cushing syndrome (CS), and to improve clinicians’ understanding of this complication.Methods: The clinical diagnosis and treatment of 3 patients with Cushing disease (CD) combined with pulmonary embolism were reviewed, and relevant literature at home and abroad was reviewed.Results...

Background: Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly characterized by overexpression of somatostatin receptor subtype 2 (SSTR2), which can be targeted by radiopharmaceutical therapy (RPT) via radiolabeled somatostatin analogues (SSAs). RYZ101 (Ac-225 DOTATATE) is a first-in-class, highly potent alpha-emitting RPT being developed for the treatment of SSTR2+ solid tumors. Alpha-particles (such as emitted by Actinium-225) have a sho...

Objective: The aim of this study is to investigate the prevalence and incidence of thyroid nodules, and associated risk factors in population-based prospective cohort study.Methods: We investigated the prevalence of thyroid nodules using the data of 3,104 adults aged over 50 years, who were enrolled in the Korean Genome and Epidemiology Study and performed thyroid ultrasonography (US) in 2011-2012. Individuals have been performed US every 2 years, during...

Objective: To investigate the prevalence of hyperuricemia in Chinese population, and the association between serum concentrations of uric acid and related metabolic disorders.Methods: This study was based on de-identified hospital information system (HIS) data collected from four tertiary hospitals in three provinces of China. A total of 432,002 patients with at least one medical visit recorded SUA measurement were screened and 374,506 were enrolled. Hyp...

Background: Childhood obesity is the single most pressing public health emergency of the 21st century. The prevalence has increased at alarming rates and globally over 41 million children under 5 years of age are classified as overweight/obese. Overweight and obese children are likely to stay obese as adults and develop multi-morbidities including type 2 diabetes, cancer, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease at an earlier age. The ava...

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 10-15% of women worldwide, characterized by high androgen levels, anovulation and/or polycystic ovarian morphology. Chronic low-grade inflammation is associated with the disorder as well as many of its comorbidities, such as obesity and type-2 diabetes. To determine the role of the immune system in the pathophysiology of PCOS, we characterized the immune profile of the dihydrotestosterone (DHT)-induced PCOS-li...

Introduction: As a tumor-suppressor gene, armadillo repeat-containing 5 (ARMC5) gene regulates steroidogenesis and cell apoptosis in manner of second-hit model. Mutations of ARMC5 gene will disturb its normal function, leading to reduced cortisol synthesis and cell apoptosis, which is acknowledged as a frequent cause of primary bilateral macronodular adrenal hyperplasia (PBMAH). Not until another somatic ARMC5 mutation occur in germline mutation carriers, will they manifest as...

Introduction: Polycystic ovary syndrome (PCOS) is the leading cause of female infertility and is associated with high degree of comorbidities including type 2 diabetes and endometrial cancer. Hyperandrogenemia is a hallmark of PCOS and contributes to endometrial-related dysfunctions, including implantation failure and miscarriage. Whether cellular heterogeneity contributes to the functioning of the endometrium is not previously studied. Therefore, the aim is to reveal cell-typ...

Background: Pancreatic neuroendocrine tumors (PNETs) are a rare, understudied form of cancer with few curative options, and their occurrence is rising. With approximately 4,000 new cases diagnosed per year in the US, and a 5-year relative survival rate of 54%, it’s imperative to understand the molecular mechanisms governing PNET carcinogenesis. To date, most studies used whole-tumor sequencing to characterize PNETs, which hampers the discovery of their microenvironment, c...