Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep236 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Type 1 diabetes and challenges ahead

Batool Maria , Qadeer Abdul , Sharma Jayant , Kyithar Ma Pyeh

The incidence of type 1 diabetes mellitus (T1DM) is rising. The demands of daily management, blood glucose variability and potential complications pose challenges in management of T1DM.The aim of this study was to determine the clinical and metabolic profiles of T1DM patients attending Midland Regional Hospital Portlaoise diabetes service in 2017 and to assess their microvascular and macrovascular complications.A retrospective anal...

ea0070ep267 | Endocrine-related Cancer | ECE2020

Raised Metanephrines in SDHB mutation- the hunt for the source

Yang Sim Sing , Al-Mrayat Ma’en

We present a case of a 24 year old lady with known SDHB mutation. She was referred from the genetics clinic in view of a strong family history of premature paraganglioma at the age of 17. On initial clinic assessment she exhibits no symptoms suggestive of paraganglioma or pheochromocytoma. Her blood pressure is normal at 120/75. pulse of 60–80bpm. Physical examination was unremarkable Her Plasma normetanephrine done on two separate occasion were elevated at 1600 pmol/l a...

ea0021p209 | Endocrine tumours and neoplasia | SFEBES2009

Utilization of various imaging modalities in the localization of tumours in MEN-1 and insulinoma

Ma Claire , Muthukuda Dimuthu , Carroll Nicholas , Whitley Sobhan , Simpson Helen

Objective: A descriptive study to summarize the experience on diagnosis of NET using various imaging modalities.Methods: Imaging was reviewed for 25 patients between 2002 and 2009 (22 MEN-1, 3 sporadic insulinoma). Of 13/25 had elevated fasting gut hormones. CT, MRI, endoscopic ultrasound (EUS), somatostatin receptor scintigraphy (SRS) and angiography were reviewed. (CT, MRI examined with arterial enhancement).Results: Most frequen...

ea0019p116 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

The effects of combined plant derived oleanolic acid and insulin on blood glucose concentration in streptozotocin-induced diabetic rats

Musabayane CT , Mapanga RF , Tufts MA , Oyedeji OO , Shode FO

We have previously attributed the hypoglycaemic effects of Syzygium cordatum leaf extract to crude ethyl acetate extract solubles (EAS) containing triterpenoid compounds. The present study was designed to isolate and characterize triterpene components EAS and investigate the antihyperglycaemic effects alone or in combination with insulin in non-diabetic and streptozotocin (STZ)-induced diabetic rats. EAS soluble extracts were obtained after defatting the S. cordatum<...

ea0019p124 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Renal effects of plant-derived oleanolic acid in streptozotocin-induced diabetic rats

Mapanga RF , Tufts MA , Shode FO , Musabayane CT

Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst.) (Myrtaceae) leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (OA) and ursolic acid (UA). For the bioactive compounds to have potential in diabetes management, they should also alleviate or prevent complications of diabetes mellitus; kidney function and cardiovascular disorders. This study i...

ea0019p377 | Thyroid | SFEBES2009

Management of maternal hypothyroidism in the joint antenatal endocrine clinic

Thanabalasingham G , Ma K , Allen K , Street P , Elsheikh M

Background: In the first trimester, the foetus is dependent on circulating maternal thyroid hormones for normal brain development. Maintenance of euthyroidism is important throughout pregnancy and maternal hypothyroidism is associated with adverse foetal outcomes.Aim: To audit the management of pregnancies complicated by hypothyroidism in a joint antenatal endocrine clinic in comparison with the UK guidelines from the British Thyroid Association (2006).<...

ea0013p83 | Clinical practice/governance and case reports | SFEBES2007

Pituitary tumour – Contraindication to thrombolysis; Caution with antiplatelet agents

Simon Godwin , Bhatia Nikhil , Al-Mrayat Ma’en

A 63-year-old gentleman with hypopituitarism secondary to non-functioning pituitary macro adenoma, treated with trans sphenoidal surgery 16 years earlier, was admitted with chest pain. His ECG showed 3 mm ST elevation in the inferolateral leads, and his subsequent cardiac enzymes were consistent with acute myocardial infarction. A decision was made not to thrombolyse him, as any intracranial tumour is an absolute contraindication to thrombolysis. He was discussed with the tert...

ea0013p172 | Diabetes, metabolism and cardiovascular | SFEBES2007

Type 2 diabetes mellitus presenting with diabetic ketoacidosis

Simon Godwin , Bhatia Nikhil , Al-Mrayat Ma’en

A 64 old year old obese (BMI 31 kg/m2) Caucasian male was admitted to our hospital with general malaise, nausea, vomiting and dehydration. He gave no preceding history of polyuria, polydipsia or weight loss. He had been receiving oral corticosteroids for established ulcerative colitis. He was found to have random plasma glucose of 70.7 mmol/l, positive serum and urine ketones, and metabolic acidosis with PH 7.27, bicarbonate 13 mmol/l and base excess −12.4. Th...

ea0012oc12 | Placenta, bone and genetics | SFE2006

Physiological blockade of gut hormones increases food intake

Kokkinos A , Vincent RP , le Roux CW , Ghatei MA , Bloom SR

BackgroundAppetite is complex, however to address the obesity epidemic, therapeutic agents would have to significantly influence appetite. Currently the most effective treatment for obesity is bariatric surgery because it reduces hunger and increases satiety. The satiety gut hormones such as peptide YY (PYY) and glucagon like peptide 1 (GLP-1) reduce appetite and food intake. Compared to lean and obese subjects, exaggerated postprandial responses of PYY ...

ea0011p65 | Clinical case reports | ECE2006

Bone marrow aplasia in a patient with panhypopituitarism responsive to sex hormone therapy. The importance of compliance with testoterone therapy

Badawi MA , Farah FS , Elkhalifa MY , Al-humaidi A , Elhadd TA

The integrity of bone marrow and its various haemopoeitic cells require several hormones including sex steroids. Sex steroids were used in the past to treat aplastic anaemia. A 27 years old Saudi male who underwent a resection of hypothalamic astrocytoma and developed panhypopituitarism was admitted to ICU with shunt related meningitis and noted to have thrombocytopenia of 90,000 anemia of 9.5 gldl, which progressed over the subsequent week following admission. He recovered fr...