Endocrine Abstracts

Background: The Controlled Antenatal Thyroid Screening II (CATS) study, a large randomised trial of thyroxine supplementation for suboptimal gestational thyroid function (SGTF), reported a higher prevalence of elevated attention deficit hyperactivity disorder (ADHD) scores in 9 year-old children exposed to higher thyroid hormone (TH) in utero. Here we investigated if this was accompanied by altered neurodevelopment.Methods: 85 children aged 11-1...

Fatty liver (steatosis) can progress to non-alcoholic fatty liver disease, increasing the risk of diabetes and cardiovascular disease. Growth hormone (GH) deficiency is associated with steatosis, while raising GH reduces steatosis. To date it remains to be determined how GH mediates this hepato-protective effect. To investigate the hepatocyte-specific actions of GH, a mouse model of adult-onset hepatocyte-specific GH receptor knockdown (aHepGHRkd) was generated by treating adu...

Liver autophagy, as assessed by accumulation of LC3-II and p62 proteins, is positively correlated with the severity of nonalcoholic steatohepatitis (NASH) in humans. Since growth hormone (GH) is negatively associated with liver steatosis and NASH development, and our laboratory has reported that steatosis and NASH develops in a mouse model of adult-onset, hepatocyte-specific GH-Receptor knockdown (aHepGHRkd), we sought to determine if GH directly regulates the hepatocyte autop...

Osilodrostat as an inhibitor of adrenal 11B-hydroxylas, is an effective medication used in the management of endogenous hypercortisolism. There are limited data regarding usage of osilodrostat in ectopic Cushing Syndrome (CS). Surgery is usually the first line treatment in ectopic CS, however the source of ectopic hormonal production often remains undiscovered for a long period of time. Meanwhile dangerous state of severe hypercortisolism needs to be managed pharmacologically ...

Background: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. During the past decade new treatments have been targeted to the androgen signaling axis either by inhibiting the binding of androgens to androgen receptor (AR) and AR nuclear translocation, or by inhibiting androgen production via CYP17A1 enzyme. Despite the significant progress on the research and new therapies, CRPC is still incurable and there...

It has been established in recent years that androgens are involved in the progression of castration resistant prostate cancer (CRPC). Although androgen deprivation therapy reduces the level of androgens and inhibits the androgen receptor, there are studies reporting that the androgen signaling axis is still involved in the development of CRPC. We have in a previous study shown that low level of β2-adrenergic receptor (ADRB2) is associated with shorter time to ...

Background: Osteoporosis is common in primary hyperparathyroidism (PHPT). It is also an indication for parathyroidectomy in PHPT. Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA) increases after successful surgery. Alendronate significantly increases BMD in PHPT patients not undergoing surgery. It is not known whether surgery alone or in combination with postoperative zoledronic acid more efficiently improves bone health in PHPT.<p class="abste...

Purpose: Although growing evidence supports the role of primary cilia (PC) in the regulation of cancer development, their possible role has not yet been studied in pituitary neuroendocrine tumours (PitNETs). The study of cilia could serve as a diagnostic tool providing new insights into the mechanisms of tumorigenesis and aggressiveness of PitNETs. Methods: A total of 86 patients with PitNETs (28 functioning and 58 non-functioning [NF-PitNETs]) and 12 co...

Background: We aimed to evaluate the added information provided by 68Ga-DOTATATE PET after two cycles of peptide receptor radionuclide therapy (PRRT) in patients with somatostatin receptor (SSTR)-expressing neuroendocrine tumors (NET).Methods: In this retrospective study, 105 patients (54 women and 51 men, 62.5&pm;10.5-year-old) with progressive NET treated with at least two cycles of 177Lu-DOTATATE were included. All patients had <...

Mesenteric paragangliomas are a rare entity; consequently, 20 cases have been reported to date. Although often found incidentally and considered benign, they have potential to metastasize. We present a case of 63-year old man with a 11-year history of the mesenteric paraganglioma. The lesion for the first time had been described on CT scan of the abdomen in 2010. However, the patient was lost to follow-up. In 2021 CT scan, followed by MRI of the abdomen, perfomed due to reccur...