Endocrine Abstracts

Background: Somatostatin (SST)/Cortistatin (CORT) system is a complex hormonal axis involved in the progression of several tumor types. However, its role has not been explored in prostate cancer (PCa), one of the most common type among men.Objectives: We aimed to investigate the presence and the pathophysiological role of SST/CORT in PCa.Methods: We analysed functional parameters in response to SST and CORT and to CORT-silencing in...

Emerging evidence indicates that the cellular machineries controlling gene expression mechanisms and genomic stability are altered in several endocrine-related cancers (ERCs), leading to some oncogenic events associated with tumour progression/aggressiveness. However, whether this phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, this study was focused on: 1) investigating the potential alteration in the levels of components of the molecular machin...

Introduction: Prolactinomas are the most commun secreting adenomas of the pituitary gland. They are classified according to their sizes into microprolactinomas (<10mm long axis) and macroprolactinoma (>=10mm long axis). According to studies its prevalence is approximately 3.5-5 for 100000 inhabitants. The diagnosis is made by the blood prolactin assay as well as the pituitary magnetic resonance imaging (MRI) which is the radiological reference exam to evaluate the dime...

Introduction: Hypothalamic obesity (HyOb) is a rare form of treatment-resistant morbid obesity associated with hypothalamic damage. Its pathophysiology is incompletely understood, and is associated with hyperphagia and hyperinsulinaemia. We sought to compare the physiology of various appetite-regulating hormones in HyOb and ‘simple’ obesity.Methods: Oral glucose-stimulated serum insulin and plasma oxytocin concentrations, and fasting concentrat...

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Objectives: Eversense XL is a fully implantable sensor for continuous glucose monitoring (CGM) that lasts for up to 180 days. Our objective was to perform a survey on user acceptance and satisfaction among our type 1 diabetic patients who had been using the Eversense XL CGM for at least 3 months.Methods: A questionnaire was devised in which the patients were asked about their experience with the Eversense XL CGM, including:-Compari...

Objective: Cushing’s disease (CD) is the most common cause of hypercortisolism after iatrogenic origin, it represents approximately 70% of patients with endogenous Cushing’s syndrome (CS) and ectopic ACTH secretion (10%). CD is caused by a corticotropin-secreting pituitary neuroendocrine tumor (ACTH-secreting Pit-NETs), 95% of cases as a microadenoma. In ACTH-dependent CS, differential diagnosis between CD and ectopic CS must be established. 40% of CD cases, any tumo...

Acromegaly is a rare disease usually diagnosed late in disease evolution. It implies for skeletal changes of most flat bones including those of the skull. Consequently, a progressive facial disfiguration occurs at slow velocity of irreversible nature. Even after curation most of these changes stay for the whole life of the patient.Aim: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) ...

Introduction: The Biomedical Engineering Group of the University of Seville, the Endocrinology and Nutrition Unit of the Virgen Macarena Hospital (ENU-VMH) and the company Igluco Tech are developing the GLUCUBE device, a new non-invasive sensor for blood glucose measurement.Objective: First validation of usability and accessibility of the device by patients in a controlled clinical environment.Material and Methods: General user-cen...

Introduction: Flash glucose monitoring expansion to an increasing number of patients with type 1 diabetes, coupled with its increased accuracy and ease of use, has increased available data on glycemic control in this population and allows detection of improvement areas in diabetes education and treatment.Objective: To analyze main parameters standardized by ATTD consensus (2019) in our population of patients with type 1 diabetes using flash glucose monit...