Searchable abstracts of presentations at key conferences in endocrinology

ea0016p69 | Bone and calcium | ECE2008

Bone metabolism in hypothalamic obesity

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Djurovic Marina , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Obesity protects from osteoporosis. Bone remodeling and energy metabolism could be regulated by the adipocyte-derived hormone, leptin acting on osteoblasts though hypothalamic pathways. Hypothalamic lesions cause obesity. Since most of these patients are also hypopituitary with low IGF1 which could affect bone metabolism the aim of our study was to investigate whether obesity would protect them from osteoporosis.Three groups of patients were studied: (1)...

ea0016p77 | Bone and calcium | ECE2008

The relationship between bone turnover and body weight and leptin in patients with Anorexia nervosa

Djurovic Marina , Pekic Sandra , Miljic Dragana , Doknic Mirjana , Petakov Milan , Stojanovic Marko , Popovic Vera

Anorexia nervosa (AN) is associated with bone loss due to weight loss, decreased caloric intake, amenorrhoea and behavioral changes. The most important predictor of the occurrence of bone loss is body weight (BMI <16.5 kg/m2). Previous studies suggested that many factors including effects of chronic undernutrition in AN patients is associated with a reduction of bone formation (osteocalcin-OC) uncoupled with increased resorption markers (crosslaps-CTx). The aim ...

ea0016p387 | Neuroendocrinology | ECE2008

Efficacy of slow release formulation of lanreotide (Somatuline Autogel® 120 mg) in patients with acromegaly: single center experience

Miljic Dragana , Nikolic-Djurovic Marina , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Popovic Vera

Somatuline Autogel® 120 mg (SATG, Ipsen, Sweeden) is a high dose sustained release aqueous gel formulation, supplied in a prefiled syringe and given by deep subcutaneous injection. The aim of this cross-sectional hospital based study, approved by the local ethical committee, was to investigate efficacy and tolerability of SATG given every 4 weeks in patients with active acromegaly.Twenty patients (9f, 11m) aged 42.9±17.8 (range 17&#1...

ea0016p390 | Neuroendocrinology | ECE2008

Cardiovascular risk factors in adult onset growth hormone deficiency (AO-GHD) without growth hormone replacement: follow-up period seven years

Djurdjevic Sandra Pekic , Doknic Mirjana , Miljic Dragana , Djurovic Marina Nikolic , Stojanovic Marko , Popovic Vera

Patients with hypopitutarism have higher cardiovascular morbidity and mortality rates than general population, as manifested by elevated fasting lipids and insulin resistance. The aim of our study was to evaluate the lipid levels and insulin responses during oral glucose tolerance test (OGTT) in adult onset growth hormone deficiency (AO-GHD), without growth hormone replacement during a follow-up period of seven years. Ten hypopituitary patients with operated non-functioning pi...

ea0014p473 | (1) | ECE2007

Bloch-sulzberger syndrome, hypothyroidism and a pituitary incidentaloma: a case report

Stojanovic Marko , Miljic Dragana , Doknic Mirjana , Djurovic Marina , Pekic Sandra , Nikolic Milos , Popovic Vera

A female patient, 34 years old, was referred to endocrinologist, for an incidentally discovered interstellar mass on MR, mild subclinical hypothyroidism and hyperprolactinemia, and irregular menstrual cycles. She was diagnosed with Bloch-Sulzberger syndrome (BSS) in neonatal age. Epilepsy, her most prominent component of BSS, was well controlled but only with triple anticonvulsant therapy (Valproate, Carbamazepine, Clonazepam). She was obese, clinically euthyroid, and exhibite...

ea0056gp7 | Acromegaly | ECE2018

Familial cancer clustering in patients with pituitary adenoma

Djurdjevic Sandra Pekic , Soldatovic Ivan , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Popovic Vera

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

ea0056p621 | Adrenal cortex (to include Cushing's) | ECE2018

Corticosteroid secretion after the soy extract application to orchidectomized adult male rats

Ajdzanovic Vladimir , Miljic Dragana , Ristic Natasa , Pendovski Lazo , Percinic-Popovska Florina , Rovcanin Zoran , Milosevic Verica

Herein, we have tested the effects of application of commercial soy extract, rich in estrogen-like isoflavones, to orchidectomized adult rats (the model of mild andropause), on the corticosteroid secretion. Exploited animal model provides the opportunity to examine the potential effects of steroid-like compounds in the hormonal milieu deprived of endogenous sex steroids along with preserved hippocampal and hypothalamic regulation of the adrenal gland function. The experimental...

ea0081ep215 | Calcium and Bone | ECE2022

Pregnancy and lactation-associated osteoporosis

Jemuovic Zvezdana , Djurovic Marina Nikolic , Djurdjevic Sandra Pekic , Miljic Dragana , Stojanovic Marko , Doknic Mirjana , Petakov Ana , Petakov Milan

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

ea0063p1112 | Pituitary and Neuroendocrinology 3 | ECE2019

Metabolic phenotype in acromegaly

Djurdjevic Sandra Pekic , Prpic MIlica , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Jemuovic Zvezdana , Djurovic Marina Nikolic , Petakov Milan

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

ea0049gp62 | Developmental &amp; Protein Endocrinology | ECE2017

Effects of prenatal dexamethasone on fetal rat ovary

Ristic Natasa , Pendovski Lazo , Manojlovic-Stojanoski Milica , Miljic Dragana , Miler Marko , Ajdzanovic Vladimir , Trifunovic Svetlana , Nestorovic Natasa , Milosevic Verica

Glucocorticoids affect the growth and maturation of fetal organ systems, but overexposure to exogenous glucocorticoids retard fetal growth and may alter developmental process in sensitive tissues. On the other hand, fetal ovary is not characterized by definitive follicular structure, but the clusters of germinative cells are predominant. Germ cells may be in meiotic prophase or with sign of degeneration.The aim of this study was to determine whether pren...